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Carbon dot powder with high fluorescence property, preparation method of carbon dot powder and application of carbon dot powder in detection of nitroimidazole drugs

A technology of nitroimidazoles and fluorescent properties, which is applied in the direction of fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of complex detection steps, cumbersome operation, and long time consumption, and achieve rapid detection, simple operation process, The effect of low production cost

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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods have disadvantages such as time-consuming, cumbersome operation, and complicated detection steps.

Method used

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  • Carbon dot powder with high fluorescence property, preparation method of carbon dot powder and application of carbon dot powder in detection of nitroimidazole drugs
  • Carbon dot powder with high fluorescence property, preparation method of carbon dot powder and application of carbon dot powder in detection of nitroimidazole drugs
  • Carbon dot powder with high fluorescence property, preparation method of carbon dot powder and application of carbon dot powder in detection of nitroimidazole drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0040] This embodiment provides a carbon dot powder with high fluorescence performance and a preparation method thereof.

[0041] Weigh 1 g of degreased rice bran dried at 40°C at low temperature, add 30mL of deionized water and 0.5mL of ethylenediamine to mix evenly by ultrasonic; then place the mixed solution in a 50mL reactor and react in an oven at 210°C for 12 hours; The cooled reaction solution was centrifuged at 5000rpm for 10min, the supernatant was passed through a 0.22μm membrane, and then dialyzed in a dialysis bag with a molecular weight cutoff of 1000Da for 72h, and then freeze-dried to obtain carbon dot powder. The carbon dot powder was dissolved in water, and its quantization yield was measured to be 9.55%.

[0042] figure 1 A high-resolution transmission electron microscope image of the carbon dot powder obtained in Example 1 of the present invention is shown.

Embodiment 2

[0044] This embodiment provides a carbon dot powder with high fluorescence performance and a preparation method thereof.

[0045] Weigh 1 g of degreased rice bran dried in an oven at 50 °C at low temperature, add 30 mL of deionized water, and 0.27 g of 1,3-2 amino-propylene glycol to mix evenly by ultrasonic; then put the mixed solution in a 50 mL reaction kettle at 180 °C React in an oven for 12 hours; centrifuge the cooled solution at 4,000 rpm for 20 minutes, pass the supernatant through a 0.22 μm membrane, and dialyze in a dialysis bag with a molecular weight cut-off of 1,000 Da for 36 hours, and freeze-dry to obtain carbon dot powder. The carbon dot powder was dissolved in water, and its quantization yield was measured to be 8.79%.

Embodiment 3

[0047] This embodiment provides a carbon dot powder with high fluorescence performance and a preparation method thereof.

[0048]Weigh 1 g of degreased rice bran dried in a 60°C oven at low temperature, add 30mL of deionized water, and 0.366g of hydroxyethylamine to mix evenly; then place the mixed solution in a 50mL reactor and react in an oven at 200°C for 12 hours; The cooled reaction solution was centrifuged at 7000rpm for 15min, the supernatant was passed through a 0.22μm membrane, and then dialyzed in a dialysis bag with a molecular weight cutoff of 3500Da for 36h, and then freeze-dried to obtain carbon dot powder. The carbon dot powder was dissolved in water, and its quantization yield was measured to be 7.59%.

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Abstract

The invention belongs to the technical field of preparation of nano composite materials, and particularly relates to carbon dot powder with high fluorescence performance, a preparation method of the carbon dot powder and an application of the carbon dot powder in detection of nitroimidazole drugs. The preparation method comprises the steps: uniformly mixing dried defatted rice bran with deionized water and a nitrogen source, carrying out a hydrothermal reaction, centrifuging the reacted solution, passing the supernatant through a membrane, optionally dialyzing, and freeze-drying to obtain carbon dot powder. The higher the content of the doped nitrogen element is, the quantization yield is greatly increased, and the quantization yield can be increased to 32.44% from 0.73% to the maximum; An adopted carbon source is defatted rice bran, raw materials are common, cheap and easy to obtain, and the preparation method of carbon dots is simple to operate and relatively green and environment-friendly; the quantization yield of the prepared nitrogen-doped carbon dots is increased by ten times or more compared with the quantization yield of non-doped nitrogen source carbon dots. The carbon dots have high detection sensitivity on the nitroimidazole drugs, has a wide linear range, and is suitable for trace detection of the nitroimidazole drugs.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanocomposite materials, and more specifically relates to a carbon dot powder with high fluorescence performance, a preparation method thereof and an application in the detection of nitroimidazole drugs. Background technique [0002] Carbon quantum dots are a new type of fluorescent small carbon nanoparticles with a particle size of less than 10 nanometers, quasi-spherical shape, and stable light emission. They were first discovered in the purification process of single-walled carbon nanotubes in 2004. Due to carbon quantum dots it has excellent photostability, small size, highly tunable photoluminescence properties, excellent biocompatibility, electrochemiluminescence, excellent multiphoton excitation (up-conversion), good solubility, High quantum yield, surface functional groups, and low toxicity make it widely used in bioimaging, biosensing, biopharmaceuticals, disease detection, optoele...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65G01N21/64
CPCC09K11/65C09K11/0883G01N21/6428Y02A50/30
Inventor 胡志雄李小敏齐玉堂张维农张燕鹏杜言
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