Medical chitosan nano-microsphere for repairing wounds and inhibiting scars and preparation method of medical chitosan nano-microsphere

Abstract

The invention relates to the field of medicines, in particular to a medical chitosan nano-microsphere for repairing wounds and inhibiting scars, and further relates to a preparation method of the medical chitosan nano-microsphere for repairing the wounds and inhibiting the scars. Aiming at the problems of poor wound repair treatment, incapability of inhibiting scars, low drug loading capacity, poor dispersity and unstable size of nano microsphere particles of the existing medical chitosan nano microsphere, the invention provides the chitosan nano microsphere. The medical chitosan nano-microsphere is prepared from the following raw materials in parts by weight: 3-6 parts of chitosan, 4-8 parts of a 1% acetate solution, 1-2 parts of ethanol, 0.1-0.2 part of ginsenoside Rg3, 0.4-0.5 part of dopamine, 0.1-0.2 part of BFGF, 4-6 parts of an emulsifier, 20-32 parts of liquid paraffin and 12-18 parts of a cross-linking agent. The medical chitosan nano-microsphere prepared by the preparation method disclosed by the invention enhances the wound repair treatment effect, can inhibit the formation of scars, has the advantages of high drug loading capacity and good dispersity, and is stable in particle size.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medical chitosan nanosphere for wound repair and scar inhibition, and also relates to a preparation method of the medical chitosan nanosphere for wound repair and scar inhibition. Background technique [0002] Nano-microsphere materials have excellent biocompatibility and adjustable biodegradability, and can be used for the embedding and release of drugs, proteins and genes. Compared with frequent injections, the use of nano-microspheres to carry drugs in the body The slow release of chitosan can achieve the ideal therapeutic effect. Among them, the medical chitosan nano-microsphere is a polymer compound chitin purified from crab shells, and a polyglucosamine is obtained after de-N-acetylation and further processing. It has the biological characteristics of selectively promoting the growth of epithelial cells and endothelial cells while inhibiting the growth of fibroblasts, and can prom...

AI Technical Summary

Problems solved by technology

[0003] The existing medical chitosan nanospheres cannot promote skin regeneration and rapid repair in the early stage, and inhibit the excessive proliferation of fibroblasts in the later stage, resulting in the inability to inhibit the formation of hypertrophic scars. The prepared medical chitosan nanospheres promote skin tissue damage The effect of repairing and healing scars is low, which affects the effect of wound repair treatment. Chitosan degrades in an acidic environment, resulting in a decrease in the viscosity of the aqueous solution, making the drug loading of medical chitosan nanospheres prepared by this method Low, poor dispersion, unstable size of medical chitosan nanospheres