Porcine circovirus, porcine pseudorabies virus and mycoplasma triple inactivated vaccine

Abstract

The invention discloses a porcine circovirus, porcine pseudorabies virus and mycoplasma triple inactivated vaccine which comprises an antigen and a vaccine adjuvant, the antigen is composed of a porcine circovirus type 2 antigen, a porcine pseudorabies virus antigen and a mycoplasma antigen, the porcine circovirus type 2 antigen is a purified, concentrated and inactivated porcine circovirus type 2 protein antigen solution, and the content of Cap protein is more than or equal to 160 [mu]g / ml; the porcine pseudorabies virus antigen is a purified, concentrated and inactivated porcine pseudorabies virus protein antigen solution, and the content of the Cap protein is more than or equal to 160 [mu]g / ml; the mycoplasma antigen is an inactivated mycoplasma protein antigen solution, and the content of the Cap protein is more than or equal to 160 [mu]g / ml; and the vaccine adjuvant is composed of a water-based high-molecular polymer adjuvant and a composite polysaccharide immunopotentiator. Foreign protein is removed through clarification filtration and ultrafiltration concentration, and the side reaction probability of the vaccine is greatly reduced; and three-proofing can be achieved through one needle, so that the number of immunization times and stress are reduced. The method is economical and practical, the immunization procedure is simplified, and the epidemic prevention cost is reduced.

Description

technical field [0001] The invention relates to the technical field of veterinary biological products, in particular to a triple inactivated vaccine of porcine circovirus, porcine pseudorabies virus and mycoplasma. Background technique [0002] Porcine circovirus disease is an infectious disease of pigs caused by porcine circovirus type 2, which causes piglet weaning syndrome, porcine dermatitis and nephrotic syndrome, and reproductive disorders in sows. Its clinical manifestations are diverse. After pigs are infected with circovirus, it can cause severe immunosuppression, resulting in secondary or concurrent other infectious diseases, such as mycoplasma, Haemophilus parasuis, Streptococcus suis and other diseases. [0003] Pseudorabies is an acute infectious disease caused by pseudorabies virus (Pseudorabiesvirus, PRV), including a variety of livestock and wild animals. Pigs are the natural host and reservoir of the disease virus. The disease is characterized by fever, sev...

AI Technical Summary

Problems solved by technology

Mycoplasma pneumonia in swine is a stubborn chronic disease. Anti-mycoplasma drug treatment can generally suppress the disease but it is difficult to clear it up. The symptoms of cough and asthma disappear after the drug is stopped, but it is easy to recur after stopping the drug.

[0005] At present, there are only related single vaccines or dual vaccines in the commercially available vaccines, and the frequency of immunization is too high, which leads to stress in pigs