A wound dressing of bacterial cellulose-based sericin peppermint oil nanoparticles and preparation method thereof

A technology of bacterial cellulose and nanoparticles, applied in the field of wound dressings, can solve the problems of long healing time and difficulty in keeping the wound moist.

Active Publication Date: 2022-05-24
XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcoming of above-mentioned prior art, provide a kind of wound dressing of bacterial cellulose base sericin peppermint oil nano particle and preparation method thereof, to solve existing dressing in the prior art that it is difficult to keep the wound surface moist, wound healing long time problem

Method used

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  • A wound dressing of bacterial cellulose-based sericin peppermint oil nanoparticles and preparation method thereof
  • A wound dressing of bacterial cellulose-based sericin peppermint oil nanoparticles and preparation method thereof
  • A wound dressing of bacterial cellulose-based sericin peppermint oil nanoparticles and preparation method thereof

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preparation example Construction

[0041]The invention provides a bacterial cellulose-based sericin peppermint oil nanoparticle wound dressing and a preparation method thereof. The preparation method specifically comprises the following steps:

[0042] Step 1, Preparation of Bacterial Cellulose (BC)

[0043] In a certain volume of deionized water, add glucose 25g / L, yeast extract 7.5g / L, peptone 10g / L and disodium hydrogen phosphate 10g / L in sequence according to the following concentrations, stir to dissolve, adjust the pH of the medium with glacial acetic acid 4-5, in order to provide a suitable environment for the growth of Acetobacter xylinum, divided into conical flasks, sealed with 2-3 layers of gauze, put into a high pressure steam sterilizer for sterilization, the sterilization temperature is 121 ℃, The sterilization time is 20 minutes to ensure that the environment for the growth of Acetobacter xylinum is absolutely sterile. Cooling after sterilization to obtain bacterial cellulose liquid culture medi...

Embodiment 1

[0071] Step 1, Preparation of Bacterial Cellulose (BC)

[0072] In a certain volume of deionized water, add glucose 25g / L, yeast extract 7.5g / L, peptone 10g / L and disodium hydrogen phosphate 10g / L in sequence according to the following concentrations, stir to dissolve, adjust the pH of the medium with glacial acetic acid It is 4-5, packed in conical flasks, sealed with 2-3 layers of gauze, and put into a high-pressure steam sterilizer for sterilization. The sterilization temperature is 121 ℃, and the sterilization time is 20min. , to prepare BC liquid culture medium;

[0073] Step 2, Extraction of sericin (SS)

[0074] Sericin is extracted by the soap alkali method. The specific process is as follows: ① Silkworm cocoon washing: Cut the silkworm cocoon into a small square of 0.5cm by 0.5cm, weigh 5g and place it in 0.02M, 100ml sodium carbonate solution, heat to 70°C and Use electric stirring for 10 min, cool to room temperature, and filter under reduced pressure. ②Put the a...

Embodiment 2

[0085] In this example, all steps are the same as in Example 1, but in Step 4, the immersion time after adding peppermint oil nanoparticles is 4h.

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Abstract

The invention discloses a bacterial cellulose-based wound dressing of sericin and peppermint oil nanoparticles and a preparation method thereof. The wound dressing is in the form of a composite film, and the composite film is composed of bacterial cellulose, sericin and peppermint oil; bacterial cellulose It is a 3D mesh biopolymer synthesized by microbial fermentation. It has good air permeability, water permeability and water holding performance, and excellent mechanical properties, which meets the basic requirements of wound dressings. Sericin is a natural hydrophilic protein in silkworm cocoons, which has the potential to be a new type of wound dressing. It has cytoprotective and mitogenic effects on fibroblasts and keratinocytes, and can promote fiber proliferation, making it beneficial to skin development. Attractive, in addition, sericin has good hydrophilicity, biocompatibility, biodegradability and good affinity for biomolecules, making the excellent moisture retention of sericin beneficial to accelerate wound healing.

Description

【Technical field】 [0001] The invention belongs to the technical field of wound dressings, and particularly relates to a bacterial cellulose-based sericin peppermint oil nanoparticle wound dressing and a preparation method thereof. 【Background technique】 [0002] The skin acts as the body's protective barrier against microbial invasion. According to the World Health Organization, 300,000 people die from skin damage every year, making skin damage a major social and economic burden. At present, microbial infection is still one of the main causes of death in clinical practice, and the resistance of microorganisms is getting stronger and stronger. Therefore, there is an urgent need to develop new materials and technologies for efficient antibacterial applications. [0003] As a biomaterial, wound dressings aim to create a suitable microenvironment for cell adhesion and proper proliferation to restore the physiological and structural properties of injured skin. There are many wo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/20A61L15/44A61L15/46C12P19/04C07K14/435C07K1/34C07K1/14C12R1/02
CPCA61L15/28A61L15/32A61L15/20A61L15/44A61L15/46C12P19/04C07K14/43586A61L2300/404A61L2300/252A61L2300/30A61L2300/624
Inventor 余雨宁张良钟吕玲
Owner XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY
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