Wound dresing of bacterial cellulose-based sericin and peppermint oil nanoparticle wound dressing and preparation method thereof

A bacterial cellulose and nanoparticle technology, applied in the field of wound dressings, can solve problems such as difficulty in keeping the wound moist and long healing time of the wound

Active Publication Date: 2021-06-04
XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcoming of above-mentioned prior art, provide a kind of wound dressing of bacterial cellulose base sericin peppermint oil nano particle and preparation method thereof, to solve existing dressing in the prior art that it is difficult to keep the wound surface moist, wound healing long time problem

Method used

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  • Wound dresing of bacterial cellulose-based sericin and peppermint oil nanoparticle wound dressing and preparation method thereof
  • Wound dresing of bacterial cellulose-based sericin and peppermint oil nanoparticle wound dressing and preparation method thereof
  • Wound dresing of bacterial cellulose-based sericin and peppermint oil nanoparticle wound dressing and preparation method thereof

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preparation example Construction

[0041]The invention provides a wound dressing of bacterial cellulose-based sericin peppermint oil nanoparticles and a preparation method thereof, the preparation method specifically comprising the following steps:

[0042] Step 1, the preparation of bacterial cellulose (BC)

[0043] In a certain volume of deionized water, add glucose 25g / L, yeast extract powder 7.5g / L, peptone 10g / L and disodium hydrogen phosphate 10g / L in sequence according to the following concentrations, stir and dissolve thoroughly, and adjust the pH of the medium with glacial acetic acid 4-5 to provide a suitable environment for the growth of Acetobacter xylinum. Pack them in conical flasks, seal them with 2-3 layers of gauze, and put them into a high-pressure steam sterilizer for sterilization. The sterilization temperature is 121°C. The sterilization time is 20 minutes to ensure that the environment for the growth of Acetobacter xylinum is absolutely sterile. Cooling after sterilization to obtain bacte...

Embodiment 1

[0071] Step 1, the preparation of bacterial cellulose (BC)

[0072] In a certain volume of deionized water, add glucose 25g / L, yeast extract powder 7.5g / L, peptone 10g / L and disodium hydrogen phosphate 10g / L in sequence according to the following concentrations, stir and dissolve thoroughly, and adjust the pH of the medium with glacial acetic acid 4-5, divided into Erlenmeyer flasks, sealed with 2-3 layers of gauze, put into a high-pressure steam sterilizer for sterilization, the sterilization temperature is 121°C, the sterilization time is 20min, and cool down after sterilization , making BC liquid culture medium;

[0073] Step 2, the extraction of sericin (SS)

[0074] Use soap alkali method to extract sericin, the specific process is: ①Silkworm cocoon washing: cut the silkworm cocoon into a small square of 0.5cm by 0.5cm, weigh 5g and place it in 0.02M, 100ml sodium carbonate solution, heat to 70°C and Use electric stirring for 10 min, cool to room temperature, and filter...

Embodiment 2

[0085] In this embodiment, all steps are the same as in embodiment 1, but in step 4, the immersion time after adding peppermint oil nanoparticles is 4h.

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Abstract

The invention discloses a wound dressing of bacterial cellulose based sericin and peppermint oil nanoparticles and a preparation method of the wound dressing. The wound dressing is in a composite film form, and the composite film is composed of bacterial cellulose, sericin and peppermint oil; the bacterial cellulose is a 3D reticular biological high-molecular polymer synthesized through microbial fermentation, has good air permeability, water permeability and water retention performance, is excellent in mechanical property, and meets the basic requirements of wound dressings. Sericin is a natural hydrophilic protein in silkworm cocoons, has the potential of becoming a novel wound dressing, has cell protection and mitosis effects on fibroblasts and keratinocytes, can promote fiber proliferation, and enables the fibers to be attractive to skin development; and besides, the sericin has good hydrophilicity, biocompatibility, biodegradability and good affinity to biomolecules, so that the excellent moisture retention of the sericin is beneficial to accelerating wound healing.

Description

【Technical field】 [0001] The invention belongs to the technical field of wound dressings, and in particular relates to a bacterial cellulose-based sericin peppermint oil nanoparticle wound dressing and a preparation method thereof. 【Background technique】 [0002] The skin acts as the body's protective barrier against microbial invasion. According to the World Health Organization, 300,000 people die from skin lesions every year, making skin lesions a major social and economic burden. At present, microbial infection is still one of the main causes of death in clinical practice, and the drug resistance of microorganisms is becoming stronger and stronger. Therefore, there is an urgent need to develop new materials and technologies for high-efficiency antibacterial applications. [0003] Wound dressings, as a biomaterial, aim to restore the physiological and structural properties of injured skin by creating a suitable microenvironment for cell adhesion and proper proliferation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/20A61L15/44A61L15/46C12P19/04C07K14/435C07K1/34C07K1/14C12R1/02
CPCA61L15/28A61L15/32A61L15/20A61L15/44A61L15/46C12P19/04C07K14/43586A61L2300/404A61L2300/252A61L2300/30A61L2300/624
Inventor 余雨宁张良钟吕玲
Owner XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY
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