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Application of young citrus chachiensis to preparation of medicine for improving gastrointestinal function

A technology of tea branch mandarin orange and gastrointestinal tract, applied in the field of biomedicine, can solve the problems that the medicinal value has not been fully exerted, and achieve the effect of improving gastrointestinal function, taking conveniently, and definite curative effect

Inactive Publication Date: 2021-06-04
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the young fruit of Chazhigan has not been developed into related products for improving gastrointestinal function in the market, and its medicinal value has not been fully utilized

Method used

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  • Application of young citrus chachiensis to preparation of medicine for improving gastrointestinal function
  • Application of young citrus chachiensis to preparation of medicine for improving gastrointestinal function
  • Application of young citrus chachiensis to preparation of medicine for improving gastrointestinal function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 tea twig mandarin young fruit capsule

[0033] (1) Get the tea branch citrus young fruit medicinal material to pulverize, pass through a 20 mesh sieve, use 95% ethanol aqueous solution to the tea branch citrus young fruit ultrasonic extraction three times, each 15min, the solution consumption is 6 times (volume ratio) of medicinal material amount, ultrasonic The frequency is 40kHz, the power is 100W, the extraction temperature is 30°C, the extract is collected and ethanol is recovered;

[0034] (2) the extract is extracted three times with ethyl acetate, and the ethyl acetate is recovered and dried and pulverized to obtain the tea branch mandarin orange fruit extract;

[0035] (3) The young fruit extract of Chazhimandarin and lactose were mixed in a ratio of 1:1 to make capsules.

Embodiment 2

[0036] The preparation of embodiment 2 tea branch citrus young fruit pills

[0037] (1) Get the tea branch orange young fruit medicinal material to pulverize, cross 60 mesh sieves, use 30% methanol aqueous solution to the tea branch orange young fruit ultrasonic extraction once, extract 20min, the solution consumption is 8 times (volume ratio) of medicinal material amount, ultrasonic frequency 40kHz, power 150W, extraction temperature 35°C, collect the extract and recover methanol;

[0038] (2) the extract is extracted three times with dichloromethane, and after recovering the dichloromethane, dry and pulverize to obtain the young fruit extract of Chazhi Citrus;

[0039] (3) The young fruit extract of Chazhimandarin and starch were mixed at a ratio of 1:2 to make pills.

Embodiment 3

[0040] The preparation of embodiment 3 tea twig mandarin young fruit granules

[0041] (1) Grind the medicinal materials of the young fruit of the tea branch mandarin orange, pass through a 40-mesh sieve, and use 30% n-butanol aqueous solution to ultrasonically extract the young fruit of the tea branch mandarin orange twice for 30 minutes. The amount of the solution is 10 times the amount of the medicinal material (volume ratio) , the ultrasonic frequency is 40kHz, the power is 200W, the extraction temperature is 40°C, the extract is collected, and n-butanol is recovered;

[0042] (2) the extract is extracted twice with n-hexane, dried and pulverized after recovering the n-hexane to obtain the young fruit extract of Chazhimandarin;

[0043] (3) The young fruit extract of Chazhimandarin and microcrystalline cellulose were mixed at a ratio of 1:3 to make granules.

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to application of young citrus chachiensis to preparation of medicine for improving the gastrointestinal function. It is found through research that the young citrus chachiensis (or a young citrus chachiensis extract or a preparation of the young citrus chachiensis extract) have the obvious gastrointestinal motility promoting function and the effects of promoting secretion of gastric juice and pepsin and enhancing the activity of the pepsin, can effectively improve the gastrointestinal function, is definite in curative effect, remarkable in effect, rapid in disintegration, convenient to take and wide in application prospect, develops the new application of the young citrus chachiensis, and also provides a new conditioning scheme for the gastrointestinal function.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of young tea branch mandarin fruit in the preparation of medicines for improving gastrointestinal function. Background technique [0002] Gastrointestinal dysfunction is a common and frequently-occurring disease in gastroenterology. The main clinical manifestations are nausea, diarrhea, abdominal pain and other symptoms. Severe dysfunction often leads to potential pathogenic risks such as chronic gastritis and peptic ulcer. Modern medicine believes that gastrointestinal dysfunction may be related to gender, race, age, living environment, economic status, education background, etc.; its etiology and pathogenesis may be related to Helicobacter pylori infection, abnormal gastric acid secretion, gastric emptying disorder, Gastric receptivity disorder, abnormal distribution of food in the stomach, abnormal gastric electrical rhythm, neuro-endocrine regulation, ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P1/00A61K131/00
CPCA61K36/752A61K2236/333A61P1/00
Inventor 杨得坡梅振英赵志敏
Owner SUN YAT SEN UNIV
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