Natamycin-loaded alginic acid gel medicine membrane and a preparation method thereof

Abstract

The invention relates to the technical field of medical materials, in particular to a natamycin-loaded alginic acid gel medicine membrane and a preparation method thereof. The natamycin-loaded alginic acid gel medicine membrane comprises the following components and contents: every 1mL of the medicine membrane contains 0.01-0.03 g of sodium alginate, 0.0025-0.0075 g of polyoxyethylene and 0.005-0.015 g of natamycin. Alginic acid gel is used as a carrier, natamycin is loaded, and an ethanol solution containing calcium ions is used for crosslinking, so that the spatial structure of the material is more cohesive, the medicine-loaded gel is more stable after membrane formation, the size of pores in a medicine membrane is reduced, membrane release is delayed, and the action time of natamycin is prolonged; alginic acid is good in histocompatibility, and eye irritation and discomfort of natamycin are reduced; the medicine membrane can be better attached to the cornea ulcer surface, and has long medicine action time, good effects, no irritation and discomfort and high acceptability of patients; and the medicine membrane is a novel ophthalmic medicine membrane which is simple in preparation method, low in cost and wide in market prospects.

Description

Technical field: [0001] The invention relates to the technical field of medical materials, and relates to a natamycin-loaded alginic acid gel film and a preparation method thereof. The alginic acid gel is used as a carrier and the natamycin is loaded into a therapeutic ophthalmic film. [0002] technical background: [0003] Fungal keratitis (FK) is a serious corneal disease. Common pathogenic fungi include Aspergillus and Fusarium. FK is one of the main causes of blindness in my country. The treatment effect of the disease is poor, and most of the patients are young adults working in the front line, which has a great impact on life and production. [0004] As an avascular organ, the cornea has unique defense mechanisms and anatomical and physiological barriers. Most topical antifungal eye drops have poor corneal penetration, and most of them are washed out by tears, blinking and drainage through the nasolacrimal duct after dripping, with little local absorption, which makes...

AI Technical Summary

Problems solved by technology

Clinically used natamycin suspension can be used to treat fungal keratitis, but natamycin has a large particle size, poor solubility, and is affected by tear secretion, so it is difficult to achieve sustained release effect

Researchers have been working on improving the administration effect of natamycin. For example, Chinese patent CN200810140337.7 discloses a cation-adhesive natamycin nano eye drop, including natamycin. agent and pH regulator, also including chitosan, Pluronic F-68 and phospholipids, wherein the mass percent concentration of phospholipids in eye drops is 0.01%-2%, the concentration of Pluronic F-68 in eye drops The mass percent concentration is 0.1%-20%, the mass percent concentration of chitosan in eye drops is 0.01-4%, the molecular weight of chitosan is 5000-300000, and the degree of deacetylation is >85%; Natamycin is usually suspended Suspension granules with a diameter of 10-1000nm are prepared from the preparation to increase the solubility of the drug, improve safety and effectiveness, and modify the natamycin drug particles of the common suspension with phospholipids and chitosan to make it Positively charged, it helps to improve the corneal absorption of drugs, enhance drug efficacy and prolong drug action time, and chitosan has bioadhesive effect, which enhances the corneal adhesion of drug particles; however, there are many types of raw materials and complicated preparation processes; China The patent application CN201911030779.0 discloses a natamycin polymer micelle eye drop, including a certain mass volume ratio of natamycin polymer micelle and phosphate buffer, wherein the natamycin polymer micelle The mass percentage of natamycin is 10-30%, and the balance is polyethylene glycol-polyglyceryl methacrylate block copolymer; the polyethylene glycol-polyglyceryl methacrylate block The copolymer is placed in ethanol to self-assemble cross-linked micelles, and the natamycin polymer micelle eye drops obtained after entrapping natamycin can prolong the release time of natamycin and reduce the number of medications, but its treatment performance did not improve

There is no report about the alginate gel film loaded with natamycin

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