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Hollow Cu7S4 nano cubic structure and preparation method and application thereof

A nano-cubic and cubic-structure technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of low photothermal conversion efficiency, low biological toxicity, cytotoxicity, etc., and achieve high photothermal conversion efficiency and simple preparation method , good biocompatibility

Pending Publication Date: 2021-05-28
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Purpose of the invention: In view of the toxicity, low stability and poor targeting of existing photothermal nanomaterials, the present invention provides a hollow Cu 7 S 4 nanocubic structure, the hollow Cu 7 S 4 The nanocubic structure has excellent photothermal conversion performance, good targeting, low biotoxicity, and low cost; it effectively solves the problems of cytotoxicity and low photothermal conversion efficiency

Method used

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  • Hollow Cu7S4 nano cubic structure and preparation method and application thereof
  • Hollow Cu7S4 nano cubic structure and preparation method and application thereof
  • Hollow Cu7S4 nano cubic structure and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Weigh 4g of polyvinylpyrrolidone (PVP) with a molecular weight of 10000 at room temperature of 25°C, dissolve it in 400mL of deionized water and stir. After magnetically stirring for 10 minutes, add 3.5mL of 0.1mol / L copper acetate solution and continue stirring. After 5min, add 3.6mL of 1mol / L copper acetate solution. L sodium hydroxide solution, adjust the pH of the solution to about 11.0, add 6 mL of 0.1mol / L ascorbic acid solution after 30 seconds, and continue stirring for 30 minutes. Then heat the oil bath to 92 ° C, add 2 mL of 0.1 mol / L sodium sulfide solution under stirring for 2 h, and after the reaction is complete, centrifuge the product for 15 min to remove the lower layer of precipitate and wash, repeat the above steps 3 times, and disperse into deionized water ( 100μg / mL), that is, hollow Cu 7 S 4 Nano-cubic structure, the side length of the cube is about 70-80nm, such as figure 1 shown. figure 2 For the obtained hollow Cu 7 S 4 UV-Vis map of the na...

Embodiment 2

[0049] Weigh 5 g of polyvinylpyrrolidone (PVP) with a molecular weight of 10,000 at room temperature at 25°C, dissolve it in 400 mL of deionized water and stir. After magnetically stirring for 10 min, add 3.5 mL of 0.1 mol / L copper acetate solution and continue stirring. After 6 min, add 4.5 mL of 1 mol / L copper acetate solution. L sodium hydroxide solution, adjust the pH of the solution to about 11.0, add 6 mL of 0.1 mol / L ascorbic acid solution after 30 seconds, and continue stirring for 40 minutes. Then heat the oil bath to 95 ° C, add 2 mL of 0.1 mol / L sodium sulfide solution under stirring for 2 h, and after the reaction is complete, centrifuge the product for 15 min to remove the lower layer of precipitate and wash, repeat the above steps 3 times, and disperse into deionized water ( 100μg / mL), that is, hollow Cu 7 S 4 nanocubic structure.

Embodiment 3

[0051] Weigh 5 g of polyvinylpyrrolidone (PVP) with a molecular weight of 24,000 at room temperature at 25°C, dissolve it in 400 mL of deionized water and stir. After magnetically stirring for 10 minutes, add 3.5 mL of 0.1 mol / L copper acetate solution and continue stirring. After 5 minutes, add 3.6 mL of 1 mol / L copper acetate solution. L sodium hydroxide solution, adjust the pH of the solution to about 11.0, add 6 mL of 0.1 mol / L ascorbic acid solution after 30 seconds, and continue stirring for 40 minutes. Then heat the oil bath to 90°C, add 2mL of 0.1mol / L sodium sulfide solution to react for 1.5h under stirring, after the reaction is complete, centrifuge the product for 15min to remove the lower layer of precipitate and wash, repeat the above steps 3 times, and disperse into deionized water (100μg / mL), that is, hollow Cu 7 S 4 nanocubic structure.

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Abstract

The invention discloses a hollow Cu7S4 nano cubic structure and a preparation method and application thereof. The side length of the hollow Cu7S4 nano cubic structure is about 70-80 nm, and the shape of the hollow Cu7S4 nano cubic structure is a hollow nano cubic structure. The preparation method comprises the following steps: dissolving polyvinylpyrrolidone in water, then adding cupric acetate, sodium hydroxide and ascorbic acid, performing stirring, performing heating in an oil bath, adding sodium sulfide for continuous reaction, and after the reaction is completed, centrifugally washing and dispersing the product. The prepared hollow Cu7S4 nano cubic structure has good stability and biocompatibility, has large absorption in a near-infrared region 900-1100 nm, is high in photothermal conversion efficiency, provides conditions for photothermal therapy of tumor cells, and is simple in preparation method, mild in conditions, environmentally friendly and suitable for industrial production. Meanwhile, due to the fact that large holes exist in the surface of the material, the material can be more efficiently applied to preparation of photothermal therapy reagents for treating cancers.

Description

technical field [0001] The invention belongs to nano inorganic materials, in particular to a hollow Cu 7 S 4 Nanocubic structures and their preparation methods and applications. Background technique [0002] Copper chalcogenides (Cu 2-x S), as an important semiconductor with unique electronic, optical, and chemical properties, is a promising material with potential applications in many fields such as sensors, solar radiation absorbers, catalysts, and nanoscale switches. Currently, several methods, such as solvothermal microwave method, solvothermal, hydrothermal, chemical transformation and ultrasonic treatment methods, have been used to synthesize Cu 2-x S nanoparticles. Cu 2-x S nanoparticles (Cu 2-x S NPs), emerging nanoplatforms with dual diagnostic and therapeutic applications, are being extensively studied in this era of "war on cancer" due to their versatility and adaptability. Cu 2- x The multifunctional properties of S NPs semiconductors have been extensive...

Claims

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Application Information

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IPC IPC(8): C01G3/12B82Y5/00B82Y40/00A61K41/00A61K31/704A61K9/00A61K47/32A61P35/00
CPCC01G3/12C01G3/003B82Y5/00B82Y40/00A61K41/0052A61K31/704A61K9/0087A61K47/32A61P35/00C01P2002/01C01P2002/72C01P2002/84C01P2002/85C01P2004/64C01P2004/38A61K2300/00
Inventor 蔡称心孙宇杰胡耀娟乔玲吴萍
Owner NANJING NORMAL UNIVERSITY
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