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Micro-needle patch for removing acnes and fading acne marks and preparation method of micro-needle patch

A technology of microneedle sticking and acne marks, which is applied in the field of biomedicine, can solve the problems of not having a good effect on acne, and achieve good market value and the effect of painless use

Inactive Publication Date: 2021-05-25
上海行渝生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most acne-removing products are applied on the affected area in the form of smearing, which does not have a good acne-removing effect

Method used

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  • Micro-needle patch for removing acnes and fading acne marks and preparation method of micro-needle patch
  • Micro-needle patch for removing acnes and fading acne marks and preparation method of micro-needle patch

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preparation example Construction

[0039]

[0040] The preparation method of the microneedle patch for removing acne and lightening acne marks of the present invention comprises the following steps:

[0041] (1) Preparation of the needle body solution: uniformly disperse the active ingredients and the microneedle framework material for removing acne and lightening acne marks in pure water to obtain the needle body solution A;

[0042] (2), preparation of the backing layer solution: uniformly disperse the microneedle framework material in pure water to obtain the backing layer solution B;

[0043] (3), preparation of the needle body: take the needle body solution A and add it to the microneedle mold, centrifuge, so that the needle body solution A is completely filled in the cavity of the microneedle mold, and recover the excess needle body solution A;

[0044](4), preparation of the backing layer: the backing layer solution B is added in the microneedle mold after step (3), and centrifuged again, so that the b...

Embodiment 1

[0053] The preparation method of the microneedle patch for removing acne and lightening acne marks in this embodiment includes the following steps:

[0054] (1), preparation of needle body solution: the active ingredients of acne and blemishes (2.0g ginsenoside mixture (the ratio of ginsenoside RK1 and ginsenoside Rh4 is 1:1), 2.0g cannabis leaf extract) and micro The needle skeleton material (2g hyaluronic acid) was uniformly dispersed in 10mL pure water to obtain the needle body solution A;

[0055] (2) Preparation of the backing layer solution: uniformly disperse the microneedle framework material (2 g of hyaluronic acid) into 10 mL of pure water to obtain the backing layer solution B;

[0056] (3) Preparation of the needle body: Take the needle body solution A and add it to the microneedle mold, and centrifuge for the first time at a speed of 3500rpm, a temperature of 4°C, and a centrifugation time of 5min, so that the needle body solution A is completely filled to the mic...

Embodiment 2

[0060] The preparation method of the microneedle patch for removing acne and lightening acne marks in this embodiment includes the following steps:

[0061] (1), preparation of needle body solution: the active ingredient (1.0g ginsenoside mixture (the ratio of ginsenoside RK1 and ginsenoside Rh4 is 1:1), 2.0g cannabis leaf extract) for acne removal and lightening acne marks ) and microneedle framework materials (1g polyvinyl alcohol, 1g polyvinylpyrrolidone) were uniformly dispersed in 10mL pure water to obtain needle body solution A;

[0062] (2) Preparation of the backing layer solution: uniformly disperse the microneedle framework material (1 polyvinyl alcohol, 1 g polyvinyl pyrrolidone) into 10 mL of pure water to obtain the backing layer solution B;

[0063] (3) Preparation of the needle body: Take the needle body solution A and add it to the microneedle mold, and centrifuge for the first time at a speed of 3500rpm, a temperature of 4°C, and a centrifugation time of 5min,...

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Abstract

The invention provides a microneedle patch for removing acnes and fading acne marks and a preparation method thereof. The microneedle patch comprises a backing layer and a needle body arranged on the surface of the backing layer, wherein the needle body comprises active ingredients for removing acnes and fading acne marks and a microneedle framework material, and the backing layer comprises the microneedle framework material; the active ingredients for removing acnes and fading acne marks are selected from more than one of ginsenoside and cannabis sativa leaf extract; the microneedle framework material is selected from more than one of hyaluronic acid, sodium hyaluronate, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, sodium carboxymethyl cellulose, hydroxypropyl-beta-cyclodextrin, sodium alginate, polylactic acid, chitosan and glucan. According to the invention, active ingredients for removing acnes and fading acne marks are combined with application of a microneedle technology, the soluble microneedle prepared by taking a water-soluble component as a matrix material is punctured into the skin, and micron-sized channels are generated in the skin, so that the active ingredients are quickly dissolved and permeated in a body.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a microneedle patch for removing acne and lightening acne marks and a preparation method thereof. Background technique [0002] "Acne" is a common name for acne, also known as acne, acne, acne and so on. In ancient Chinese medicine, it was called facial sores and wine thorns. Acne is a common disease in dermatology, which is a disease that occurs in the pilosebaceous glands. The etiology of acne is relatively complicated, and it is generally believed that it is mainly caused by the following five reasons: abnormal regulation of sebum secretion by androgen, abnormal keratinization, microbial infection, inflammatory response, and immune response. Among them, microbial infection and inflammatory response are closely related to Propionibacterium acnes. Marijuana (Cannabissativa L.), also known as hemp or hemp, is a plant of the family Moraceae and the genus Cannabi...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61K9/00A61K47/36A61K47/32A61P17/10A61P17/00A61M37/00A61K31/704
CPCA61K36/60A61K31/704A61K9/0021A61K47/36A61K47/32A61P17/10A61P17/00A61M37/0015A61M2037/0023A61M2037/0053
Inventor 宋杰江凯范代娣段志广
Owner 上海行渝生物科技有限公司
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