Preparation process of sustained-release gel ointment for treating breast diseases

Abstract

The invention provides a preparation process of a sustained-release gel ointment for treating breast diseases. The preparation process comprises the steps of raw material selection, grinding, washing, drying, coarse grinding, fine grinding, superfine grinding, superfine grinding, incision enzymolysis, excision enzymolysis, low-temperature spray drying and gel ointment preparation. According to the invention, a mode of gradual crushing until superfine crushing is adopted, so that extraction of effective components is facilitated. Complex enzyme is adopted for incision enzymolysis, the enzymolysis effect is good, and the yield is high. Flavourzyme is adopted for excision enzymolysis, so that the peculiar smell and bitter taste of the product are removed, and the quality of the product is improved. The enzymatic reaction is thorough, inactivating enzyme is not needed, and the activity of antler plate protein polypeptide is improved. The prepared gel ointment has a slow release effect and can maintain a stable treatment concentration. The ointment can be directly pasted on an affected part and takes effect quickly. The ointment is a percutaneous absorption preparation, so that the first-pass effect is avoided. The effects of enlarging and beautifying breasts are achieved. Micromolecule polypeptide is more beneficial to absorption and utilization by human bodies.

Description

technical field [0001] The invention relates to the technical field of gel paste technology. The invention relates to a preparation process of a gel ointment, in particular to a preparation process of a slow-release gel ointment for treating mammary gland diseases. Background technique [0002] Deer antlers, commonly known as antler hats, antler plates, and deer flower pots, are the by-products of velvet from ginseng, mink fur, and velvet in the "Three Treasures of Northeast China". Base, antlers off the plate taste salty, warm in nature, non-toxic, return kidney, liver meridian. Over the years, it has been included in the "Chinese Pharmacopoeia" according to the Chinese medicinal material antler, and "Shen Nong's Materia Medica" records: "mainly treats malignant sores and carbuncles, expels evil spirits, and leaves blood in the yin." However, it has not been well developed and utilized for a long time, and it is only a primary processed product, which is mainly taken dire...

AI Technical Summary

Problems solved by technology

[0006] Most of the currently commercially available Chinese patent medicines for the treatment of breast hyperplasia and mastitis patients are oral preparations, and the first-pass effect is obvious, which greatly reduces the dose of the drug reaching the lesion, which affects the curative effect. Increasing the dosage of oral preparations will not only cause adverse reactions The risk will increase, and it involves patient tolerance issues; there are currently no small-molecule sustained-release peptide breast treatment medical devices for the products on the market

[0007] There is an existing patent for enzymatic hydrolysis of deer antler off-disc protein polypeptide. The enzyme used in the endolytic enzymatic hydrolysis is relatively single, the degree of enzymatic hydrolysis is not high, and the extraction rate is low. Most of the obtained products are total peptides with a large molecular weight, which is not conducive to human absorption and utilization; Existing enzymatic hydrolysis patents basically do not have an exolytic enzymatic hydrolysis stage, resulting in the failure of the molecular weight of polypeptide products to continue to decrease, and most of the products have peculiar smell and bitter taste, which affects product quality