Composite adsorption material applied to field of blood purification and preparation method of composite adsorption material

Abstract

The invention discloses a composite adsorption material applied to the field of blood purification. A carrier of the composite adsorption material is a porous silicon group carrier, the carrier immobilizes an amino ligand through a cross-linking agent, the silicon group is polysiloxane, the cross-linking agent is malonaldehyde, butanedialdehyde or glutaraldehyde, and the amino ligand is polymyxin B, histidine or lysine. The preparation method comprises the following steps: 1) synthesis of the spherical silicon group carrier: taking organic silicon and gamma-aminopropyltriethoxysilane as monomers, adding the monomers into an organic solvent A and deionized water, carrying out hydrolytic condensation reaction under the action of a catalyst to obtain polysiloxane, preparing an aqueous solution containing a dispersing agent, adding polysiloxane and a pore-foaming agent, conducting reacting for 10-20 hours under an alkaline condition to obtain silicon group carrier particles, conducting washing, and conducting drying in vacuum to obtain a porous silicon-based carrier; 2) aldehyde group activation: taking the porous silicon group carrier to react with a cross-linking agent; and 3) ligand immobilization: taking the silicon group carrier with the activated aldehyde group to react with an amido-containing ligand in a solvent B, and washing the product to be neutral to obtain the product.

Description

technical field [0001] The invention relates to the technical field of materials used for blood purification, in particular to a composite adsorbent for blood perfusion / plasma adsorption and a preparation method thereof. Background technique [0002] Endotoxin is a very strong inflammatory and pyrogenic substance, a trace amount can cause serious damage to human immune function, and can cause respiratory distress, organ failure, irreversible shock and even death, and its fatality rate is as high as 40%- 90%. Endotoxemia refers to a pathophysiological manifestation caused by the release of a large amount of endotoxin into the blood by bacteria in the blood or the bacteria in the lesion, or the infusion of a large amount of endotoxin-contaminated fluid. In addition, in the pathogenesis of endotoxemia, the role of a series of inflammatory factors produced by the body cannot be ignored. Inflammatory factors refer to various cytokines involved in inflammatory response, includin...

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Problems solved by technology

At present, research at home and abroad mainly uses natural polymers such as agarose gel, chitosan, and cellulose as carriers, and amine-based substances as ligands, and has achieved good in vitro adsorption effects, but there is generally a large amount of ligand coupling. Small, poor mechanical strength and other defects, easy to break during storage, transportation, and use, forming particles that are likely to cause blood clots in patients, visible foreign matter, dust, etc.

Other carriers involved in recent years, such as polystyrene divinylbenzene resin, porous epoxy resin, and polystyrene porous polymer used in patents 201410717344.4, 201610057333.7, and 201811606288.1, have defects such as poor blood compatibility; organic resins are limited Due to the performance of the material itself, there are defects such as poor carrier strength, small amount of ligand coupling, and poor blood compatibility.

At present, most of the blood purification treatment products for endotoxemia are combined treatment with hemoperfusion products that absorb endotoxin and products that absorb inflammatory factors, which not only increases the economic burden of patients, but also increases the patient's external Circulating blood volume, presenting a higher safety risk to the patient

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