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Stable type NMN sustained-release micropellets, preparation method therefor and application of stable type NMN sustained-release micropellets

A sustained-release pellet and stable technology, which is applied in the field of stable NMN sustained-release pellets and its preparation, can solve the problems that NMN microcapsules do not have a sustained-release effect and the NMN activity has a large impact, and achieve excellent enteric-coated sustained-release Effects of performance, protective activity, ease of administration

Pending Publication Date: 2021-04-13
XIAMEN KINGDOMWAY BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defect that the NMN microcapsules obtained by the existing method do not have a sustained release effect and have a greater impact on the activity of NMN, and provide a stable NMN with a sustained release effect and a lesser impact on the NMN activity. Sustained-release pellets, preparation method and application thereof

Method used

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  • Stable type NMN sustained-release micropellets, preparation method therefor and application of stable type NMN sustained-release micropellets
  • Stable type NMN sustained-release micropellets, preparation method therefor and application of stable type NMN sustained-release micropellets
  • Stable type NMN sustained-release micropellets, preparation method therefor and application of stable type NMN sustained-release micropellets

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Experimental program
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preparation example Construction

[0039] The preparation method of the stable NMN sustained-release pellets provided by the invention comprises:

[0040] S1. Mix the core material and the stent wall material in a solvent to form a composite solution, and pass supercritical CO into the composite solution 2 fluid, at a temperature and pressure sufficient to make supercritical CO 2 The fluid is maintained under supercritical conditions for a period of time so that the supercritical CO 2 The fluid dissolves in the stent wall material so that the stent wall material expands, and then quickly releases the pressure so that the stent wall material solidifies around the core material to obtain NMN liposome nanospheres; the core material contains NMN, and the stent wall material contains Contains monoglycerides and phospholipids;

[0041] S2. Put the blank pellet core in the negative pressure bottom spray regular flow fluidized bed, and control the temperature in the negative pressure bottom spray regular flow fluidiz...

Embodiment 1

[0052] Formula composition

[0053] Formula composition Feeding amount / part NMN 9 glyceryl monolaurate 40 egg yolk lecithin 51 Microcrystalline Cellulose Blank Ball Core 75 glyceryl acetate 0.5 Ethyl cellulose 21 talcum powder 0.5

[0054] S1. Dissolve the NMN raw material with 1 part of water evenly, mix glycerol monolaurate and egg yolk lecithin evenly, then add 400 parts of ethanol solution, ultrasonically dissolve for 30 minutes, mix the above two solutions evenly and put them in an autoclave. Supercritical CO 2 Fluid, set the process parameters as follows: temperature 35°C, pressure 10MPa, time 10min, and then quickly release the pressure to obtain NMN liposome nanospheres.

[0055] S2. Place the microcrystalline cellulose blank pellet core in a negative pressure bottom spray regular flow fluidized bed, control the temperature in the negative pressure bottom spray regular flow fluidized bed at 30°C, adjust the air ...

Embodiment 2

[0057] Formula composition

[0058] Formula composition Feeding amount / part NMN 10 Glyceryl monostearate 30 Soy lecithin 60 Sucrose Blank Ball Core 70 Phthalates 3 Methacrylic acid-ethyl acrylate copolymer 15 talcum powder 1

[0059] S1. Dissolve the NMN raw material with 1 part of water evenly, mix glycerol monostearate and soybean lecithin evenly, add 150 parts of ethanol solution, ultrasonically dissolve for 30 minutes, mix the above two solutions evenly, put them in an autoclave, and into supercritical CO 2 Fluid, set the process parameters as follows: temperature 40°C, pressure 30MPa, time 15min, and then quickly release the pressure to obtain NMN liposome nanospheres.

[0060] S2, place the sucrose blank core in the negative pressure bottom spray regular flow fluidized bed, the temperature in the negative pressure bottom spray regular flow fluidized bed is controlled at 35°C, adjust the air flow of the fluidized b...

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Abstract

The invention belongs to the field of NMN application and relates to stable type NMN sustained-release micropellets, a preparation method therefor and application of the stable type NMN sustained-release micropellets. The preparation method for the stable type NMN sustained-release micropellets comprises the steps: preparing NMN liposome nanospheres from a core material and a support wall material by employing a supercritical CO2 fluid technology; and placing blank pellet cores in a negative-pressure bottom-jet regular-flow fluidized bed, controlling a temperature to 30 DEG C to 40 DEG C, adjusting a fluidized state, uniformly mixing the NMN liposome nanospheres with an enteric coating material, then, spraying the mixture to the blank pellet cores for coating, and carrying out drying after the coating ends up, thereby obtaining the stable type NMN sustained-release micropellets. According to the invention, by employing a double-layer embedding technology, the obtained NMN micropellets have excellent enteric sustained-release performance, can accurately achieve slow release in intestinal canals and are stable and fruitful in drug release, little in gastrointestinal tract irritation and high in bioavailability, and thus, the effects of convenient administration, high drug bioavailability and good sufferer compliance can be achieved.

Description

technical field [0001] The invention belongs to the application field of NMN, and in particular relates to a stable NMN sustained-release pellet and a preparation method and application thereof. Background technique [0002] β-nicotinamide adenine mononucleotide (NMN) is a physiological substance in the human body, present in all living cells including human cells. NMN is a cofactor for many enzymes, most of which catalyze oxidation-reduction reactions. NMN has the functions of anti-aging, improving immunity, and treating cardiovascular and cerebrovascular diseases. [0003] At present, NMN is made into microcapsules by spray-drying granulation technology, but this method has certain disadvantages. The core material may remain on the surface of the microcapsules, and there is a risk of being oxidized, which is likely to cause damage to the components. In addition, the spray drying granulation technology needs to be carried out at a relatively high temperature of 150-170°C,...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/24A61K47/14A61K47/32A61K47/38A61K31/706A61P9/10A61P39/06A61P37/04
CPCA61K9/5015A61K9/5042A61K9/5078A61K31/706A61P9/10A61P37/04A61P39/06
Inventor 胡杨王文积林木荣
Owner XIAMEN KINGDOMWAY BIOTECH CO LTD
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