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Method for preparing multiple Pickering emulsion from crystalline block copolymer micelles

A technology of block copolymers and copolymers, applied in the direction of emulsion delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems that solid particles are not easy to be degraded and harmful, and overcome the excessive oil-soluble emulsifier , slow and controlled release, good emulsion stability

Active Publication Date: 2021-02-09
QUZHOU RES INST OF ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention aims to overcome the defect that the solid particles in the Pickering emulsion system in the prior art are not easy to be degraded, and at the same time overcome the deficiency that small molecule emulsifiers cause harm to the human body

Method used

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  • Method for preparing multiple Pickering emulsion from crystalline block copolymer micelles
  • Method for preparing multiple Pickering emulsion from crystalline block copolymer micelles
  • Method for preparing multiple Pickering emulsion from crystalline block copolymer micelles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) Block copolymer PEG 2k -PCL 19.4k and PCL 1.9k -PEG 20k -PCL 1.9k Preparation of:

[0061] PEG 2k -PCL 19.4k Preparation of block copolymer: 0.5g polyethylene glycol monomethyl ether (average molecular weight is 2000Da), 5g ε-caprolactone monomer, 0.028g stannous octoate are placed in a dry flask, under argon protection , reacted at 120°C for 12 hours; after the reaction, the reaction mixture was dropped into ice n-hexane to precipitate, filtered and dried to obtain PEG 2k -PCL 19.4k block copolymers.

[0062] PCL 1.9k -PEG 20k -PCL 1.9k The preparation of block copolymer: 2.5g polyethylene glycol (average molecular weight is 20000Da), the epsilon-caprolactone monomer of 0.5g, 0.015g stannous octoate are placed in dry flask, under argon protection, in React at 120°C for 12 hours; after the reaction, drop the reaction mixture into ice n-hexane to precipitate, filter and dry to obtain PCL 1.9k -PEG 20k -PCL 1.9k block copolymers.

[0063] The obtained ...

Embodiment 2

[0069] (1) Block copolymer PCL 5.1k -PEG 8k -PCL 5.1k 、PDLA5.8k -PEG 5k -PDLA 5.8k and PLLA 3k -PEG 10k -PLLA 3k Preparation of:

[0070] PCL 5.1k -PEG 8k -PCL 5.1k Preparation of block copolymer: 4g polyethylene glycol (average molecular weight is 8000Da), 5g ε-caprolactone monomer, 0.045g stannous octoate are placed in a dry flask, under the protection of argon, at 120 ℃ React for 12 hours; after the reaction, drop the reaction mixture into ice n-hexane to precipitate, filter and dry to obtain PCL 5.1k -PEG 8k -PCL 5.1k block copolymers.

[0071] PDLA 5.8k -PEG 5k -PDLA 5.8k The preparation of block copolymer: 2.08g polyethylene glycol (average molecular weight is 5000Da), the dextrolactide monomer of 5g, 0.035g stannous octoate are placed in dry flask, under argon protection, at 120 ℃ for 12 hours; after the reaction, drop the reaction mixture into ice n-hexane to precipitate, filter and dry to obtain PDLA 5.8k -PEG 5k -PDLA 5.8k block copolymers.

[00...

Embodiment 3

[0079] (1) Block copolymer PEG 2k -PGA 5.2k 、PEG 5k -PDLA 8k and PLLA 3.7k -PEG 5k -PLLA 3.7k Preparation of:

[0080] PEG 2k -PGA 5.2k The preparation of block copolymer: 2g polyethylene glycol monomethyl ether (average molecular weight is 2000Da), the glycolide monomer of 5g, 0.035g stannous octoate are placed in the flask of drying, under argon protection, at 120 ℃ for 12 hours; after the reaction, drop the reaction mixture into ice n-hexane to precipitate, filter and dry to obtain PEG 2k -PGA 5.2k block copolymers.

[0081] PEG 5k -PDLA 8k Preparation of block copolymer: 3.13g polyethylene glycol monomethyl ether (average molecular weight is 5000Da), 5g dextrolactide monomer, 0.041g stannous octoate are placed in a dry flask, under argon protection , reacted at 120°C for 12 hours; after the reaction, the reaction mixture was dropped into ice n-hexane to precipitate, filtered and dried to obtain PEG 5k -PDLA 8k block copolymers.

[0082] PLLA 3.7k -PEG 5k ...

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Abstract

The invention relates to the technical field of chemical engineering and biological agents, and discloses a method for preparing multiple Pickering emulsion from crystalline block copolymer micelles,which comprises the following steps: (1) polymerizing hydrophilic macromolecules and hydrophobic monomers to obtain a hydrophilic block copolymer and a hydrophobic block copolymer; (2) preparing an aqueous dispersion A of the hydrophobic block copolymer micelles and an aqueous dispersion B of the hydrophilic block copolymer micelles; (3) high-speed shearing and mixing the aqueous dispersion A andan oil phase to obtain a W1 / O type Pickering emulsion; and (4) high-speed shearing and mixing the W1 / O type Pickering emulsion and the aqueous dispersion B to obtain the W1 / O / W2 type multiple Pickering emulsion. According to the invention, the multiple Pickering emulsion is obtained by only taking biodegradable block copolymer micelle as a particle emulsifier without any small molecular emulsifier, so that the multiple Pickering emulsion not only has good emulsion stability, but also has biodegradability, and the double Pickering emulsion can be better applied to the fields of biomedical preparations and the like.

Description

technical field [0001] The invention relates to the technical fields of chemical engineering and biological preparations, in particular to a method for preparing multiple Pickering emulsions from crystalline block copolymer micelles. Background technique [0002] Amphiphilic block copolymers refer to block copolymers that contain both hydrophilic segments and hydrophobic segments in the same polymer chain. The different blocks of amphiphilic block copolymers are usually thermodynamically incompatible and microphase separation can occur, but due to the covalent bond interactions between the blocks, the phase separation is limited to the microscopic size range. In selective solvents, due to the difference in solubility of different blocks, when the copolymer concentration exceeds the critical micelle concentration (CMC), the amphiphilic block copolymers can form self-assembled structures such as core-shell micelles. , drug sustained release, stable emulsion and other fields h...

Claims

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Application Information

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IPC IPC(8): A61K9/113A61K47/10A61K47/34
CPCA61K9/113A61K47/34A61K47/10
Inventor 单国荣林超胡镜潘鹏举
Owner QUZHOU RES INST OF ZHEJIANG UNIV
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