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High-activity low-temperature plasma as well as preparation method and application thereof

A low-temperature plasma and high-activity technology, applied in the field of plasma, can solve the problems of low utilization rate, limited therapeutic effect, and ineffective effect

Pending Publication Date: 2021-02-02
HANGZHOU QINGKE ENERGY SAVING ENVIRONMENTAL PROTECTION TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the existing drug treatment is not only expensive, but also has a low utilization rate of intravenous and oral drugs, the therapeutic effect is extremely limited, the systemic side effects are large, and it can only delay the process of fibrosis, but cannot reverse or cure it.
Conventional atomizers just spray water mist, the effect is not obvious

Method used

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  • High-activity low-temperature plasma as well as preparation method and application thereof
  • High-activity low-temperature plasma as well as preparation method and application thereof
  • High-activity low-temperature plasma as well as preparation method and application thereof

Examples

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preparation example Construction

[0043] A method for preparing a high-activity low-temperature plasma, comprising the following steps: under the action of a high-voltage electric field, the working medium is excited by ionization to generate a high-activity low-temperature plasma with high-energy neutral particles, charged particles, and free radicals at a macroscopic temperature close to room temperature body, the high-activity low-temperature plasma acts on cells and extracellular matrix, inhibits extracellular matrix aggregation, fibrosis and myofibroblasts, and promotes the regeneration of damaged tissue cells.

[0044]Specifically, under the action of a high-energy electric field, a highly active low-temperature plasma with a macroscopic temperature close to room temperature is generated: excited state / metastable state / high-energy neutral particles with an oxidation potential greater than 1.2V, charged particles, free radicals (oxygen-containing free radicals, Nitrogen-containing free radicals, etc.), rel...

Embodiment 1

[0064] The working medium is air, and the high-activity low-temperature plasma is produced by the above-mentioned preparation method, and its electron density is 10 8 ~10 16 / cm 3 , The density of the hydroxyl group (·OH) is 10 11 ~10 15 / cm 3 , Highly active low-temperature plasma acts on fibroblasts and myofibroblasts. see figure 2 , the viability of fibroblasts and myofibroblasts treated by high-activity low-temperature plasma is much lower than that before treatment, that is, high-activity low-temperature plasma can effectively inhibit the proliferation of lung fibroblasts.

Embodiment 2

[0066] The working medium is water vapor, and the high-activity low-temperature plasma is produced by the advanced preparation method, and its electron density is 10 12 ~10 21 / cm 3 , The density of the hydroxyl group (·OH) is 10 12 ~10 19 / cm 3 .

[0067] Specifically, see image 3 , the mice with pulmonary fibrosis were treated with high-activity low-temperature plasma by means of nebulization inhalation for 1 hour a day for 21 consecutive days, and the survival rate of the above-mentioned mice was maintained at 100%. In contrast, the survival rate of mice with pulmonary fibrosis dropped from 100% to 50% after 21 days without treatment. It is concluded that the treatment of pulmonary fibrosis by high-activity low-temperature plasma can significantly improve the survival rate.

[0068] see also Figure 4 , after intratracheal instillation of bleomycin (5 μg / kg), the mice were treated with high-activity low-temperature plasma (1hr / day) after 3 weeks, 2 weeks, 1 week an...

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Abstract

The invention discloses high-activity low-temperature plasma, a preparation method and application thereof. The temperature is controlled to be -30 to 300 DEG C under the action of a high-voltage electric field, a working medium is ionized and excited, high-activity low-temperature plasma with the macroscopic temperature close to the room temperature is generated, and the high-activity low-temperature plasma acts on cells and extracellular matrixes; cell membranes are polarized, oxidative stress reaction is caused, extracellular matrix aggregation, fibrosis and myofibroblasts are inhibited, and the regeneration of damaged tissue cells is promoted. The high-activity low-temperature plasma has the characteristics that the high-activity low-temperature plasma comprises oxygen-containing freeradicals and nitrogen-containing free radicals, is wrapped by a working medium, is high in activity, small in particle and high in stability, and can be directly inhaled into a respiratory system. Andas the high-activity low-temperature plasma does not contain other harmful substances and does not pass through other internal organs, no side effect is caused to human bodies.

Description

technical field [0001] The invention relates to a high-activity low-temperature plasma, a preparation method and an application thereof. Background technique [0002] Fibrosis can occur in a variety of organs. The main pathological changes are the increase of fibrous connective tissue and the reduction of parenchymal cells in organ tissues. Continuous progress can lead to organ structural damage, functional decline, and even failure, which seriously threaten human health and life. [0003] Worldwide, tissue fibrosis is the main cause of disability and death in many diseases. According to relevant statistics in the United States, nearly 45% of the patients who died of various diseases in this country can be attributed to tissue fibrosis. Fibrosis is also a major pathological feature of many chronic immune diseases. [0004] Traditional cell or tissue fibrosis treatment methods generally use intravenous or oral medicines, conventional nebulizers, etc. to inhibit and improve c...

Claims

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Application Information

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IPC IPC(8): H05H1/24H05H1/46A61N1/44
CPCH05H1/2406H05H1/46A61N1/44H05H2277/10
Inventor 唐峰石蕾
Owner HANGZHOU QINGKE ENERGY SAVING ENVIRONMENTAL PROTECTION TECH CO LTD
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