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Yttrium-based metal-organic framework material and application thereof

An organic framework and metal-based technology, applied in the field of porous metal-organic framework materials, can solve the problems of missing the best treatment opportunity and inability to evaluate treatment methods affected by diseased tissues, and achieve the effects of reducing treatment costs, mild conditions, and easy operation

Active Publication Date: 2021-01-29
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the relative independence and disconnection of clinical diagnosis and treatment often miss the best treatment opportunity, and the precise positioning and real-time monitoring of lesion tissue cannot be performed during treatment, which affects the clinical evaluation of effective treatment methods

Method used

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  • Yttrium-based metal-organic framework material and application thereof

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preparation example Construction

[0026] In a second aspect, the present invention provides a method for preparing yttrium-based metal-organic framework (Y-MOF), comprising the following steps:

[0027] (1) provide respectively the aqueous solution of trivalent yttrium ion and the organic ligand solution containing organic ligand L and o-fluorobenzoic acid;

[0028] (2) Mix the aqueous solution of trivalent yttrium ions in step (1) and the organic ligand solution containing organic ligand L and o-fluorobenzoic acid, and then react in airtight conditions at 100-120°C for 2-3 days, After cooling, solid-liquid separation, organic solvent washing and drying, the yttrium-based metal-organic framework (Y-MOF) is finally obtained.

[0029] Wherein, the organic ligand L is 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine, 2,4,6-tris(4-pyridine)1,3,5 - Triazine or pyridine 1,3,5-tribenzoate.

Embodiment 1

[0032] (1) 22mg of yttrium nitrate Y (NO 3 ) 3 Dissolve in 1.8mL of aqueous solution to make Y(NO 3 ) 3 Aqueous solution; 24 mg of 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine and 346.2 mg of o-fluorobenzoic acid were dissolved in 12 mL of N,N-dimethylformamide , to prepare an organic ligand solution with a molar concentration of 0.0042 mol / L of 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine and a molar concentration of 0.201 mol / L of o-fluorobenzoic acid .

[0033] (2) The above 1.8mL Y(NO 3 ) 3 The aqueous solution and 12mL of organic ligand solution were placed in a reaction kettle, ultrasonicated at an ultrasonic frequency of 25KHz for 8min, then placed at 105°C for 48h, cooled to room temperature, filtered, and treated with N,N-dimethylformamide The solid particles obtained after filtration are washed and dried to obtain yttrium-based metal-organic framework material (Y-MOF), whose chemical formula is: Y 4 (C 24 N 3 h 12 o 10.5 ) 2 ·(DMF) 3.5 ·(H 2 O).

Embodiment 2

[0035] (1) 19.8mg of yttrium nitrate Y (NO 3 ) 3 Dissolve in 1.8mL of aqueous solution to prepare Y(NO 3 ) 3 aqueous solution; 21 mg of 2,4,6-tris(4-pyridine) 1,3,5-triazine and 334.8 mg of o-fluorobenzoic acid were dissolved in 12 mL of N,N-dimethylacetamide to form 2,4,6-tris(4-pyridine)1,3,5-triazine molar concentration of 0.004mol / L, o-fluorobenzoic acid molar concentration of 0.200mol / L organic ligand solution.

[0036] (2) The above 1.8mL Y(NO 3 ) 3 The aqueous solution and 12mL organic ligand solution were placed in a reaction kettle, ultrasonicated at an ultrasonic frequency of 30KHz for 7min, then placed at 110°C for 48h, cooled to room temperature, filtered, and treated with N,N-dimethylacetamide The solid particles obtained after filtration are washed and dried to obtain yttrium-based metal-organic framework material (Y-MOF), whose chemical formula is: Y 4 (C 18 N 6 h 9 ) 2 ·(DMF) 3.5 ·(H 2 O).

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Abstract

The invention discloses a yttrium-based metal organic framework material and application thereof. The chemical formula of the yttrium-based metal organic framework material (Y-MOF) is Y<4> (M)< 2>. (DMF)<3.5>. (H<2>O), and in the chemical formula, M is 2, 4, 6-tri (4-carboxyl phenyl) 1, 3, 5-triazine, 2, 4, 6-tri (4-pyridine) 1, 3, 5-triazine or 1, 3, 5-tribenzoic acid pyridine. The yttrium-basedmetal organic framework material (Y-MOF) prepared by the invention is of a porous structure, has better biocompatibility and water stability, can be used as a carrier material for simultaneously loading metal ions (Mn < 2 + >, Fe < 2 + > and the like) and drug molecules (methotrexate, busulfan, adriamycin and the like), and has the effects of magnetic resonance imaging, chemodynamic therapy and chemical drug therapy; the yttrium-based metal organic framework material (Y-MOF) is prepared by adopting a solvothermal method, so that the method is simple, convenient and safe to operate, the raw materials are easy to obtain, and the conditions are mild.

Description

technical field [0001] The invention relates to a porous metal-organic framework material, in particular to a yttrium-based metal-organic framework material (Y-MOF) and an application thereof. Background technique [0002] With the development of medical technology, the level of cancer treatment has been greatly improved. Common clinical cancer treatment methods mainly include chemotherapy, surgery and radiotherapy, etc., but they have disadvantages such as long treatment time, high treatment cost, and incomplete treatment effect. . Hyperthermia, photodynamic therapy, and chemodynamic therapy are several cancer treatment methods that have emerged in recent years. Chemodynamic therapy has attracted much attention because of its simple conditions, good effect, and targeting. Chemodynamic therapy is the endogenous Fe in tumor cells 2+ ,Mn 2+ , Ti 2+ ,Cu 2+ Under the action of plasma, catalytic H 2 o 2 A new tumor therapy technology that generates strong oxidative hydroxy...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61K49/18A61K49/10A61K47/69A61K47/54
CPCC08G83/008A61K47/545A61K49/103A61K47/6921A61K49/1818Y02A50/30
Inventor 林文鑫黄霞娟余世桨王岩陈建军
Owner ZHEJIANG SCI-TECH UNIV
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