Preparation method of tanshinone Ⅱa vascular stent based on 3D printing

Abstract

The invention discloses a method for preparing a tanshinone IIA vascular stent based on 3D printing, comprising the following steps: a. modeling: designing a 3D model of a vascular stent to obtain modeling data; b. preparing a printing solution: weighing tanshinone IIA raw materials, Add ethanol and dissolve it in an ultrasonic instrument to obtain solution A; take another polylactic acid, mix it with solution A, and add dichloromethane to dissolve it, and obtain solution B; c, 3D printing vascular stent: input the modeling data into the 3D printer In the program, put solution B into the 3D printing syringe, prepare a cylinder that is the same size as the inner diameter of the blood vessel, rotate the cylinder, extrude solution B from the 3D printing syringe, and print it on the surface of the cylinder to obtain a stent sample; d 1. After drying and cooling the vascular stent sample, a finished vascular stent is obtained. The invention not only has the characteristics of reducing the probability of vascular restenosis, thrombosis and blood vessel wall damage, but also has the characteristics of high drug loading, effective and uniform distribution of drugs, and long release time.

Description

technical field [0001] The invention relates to the field of medical device preparation, in particular to a method for preparing a tanshinone IIA vascular stent based on 3D printing. Background technique [0002] In recent years, with the continuous improvement of people's living standards, cardiovascular disease has become a major threat to human health and one of the important factors leading to human death and disability. With the development of endovascular treatment technology, endovascular stent implantation has become one of the most effective methods for the treatment of cardiovascular diseases. Vascular stent refers to the placement of internal stents in the diseased segment on the basis of lumen balloon expansion to support the stenotic and occluded segment of the vessel, reduce elastic recoil and reshaping of the vessel, and maintain smooth blood flow in the lumen. [0003] Tanshinone IIA (Manshinone IIA, TA) is a fat-soluble phenanthrene quinone compound extract...

AI Technical Summary

Problems solved by technology

However, for vascular stents, the material requirements and dimensional accuracy requirements are relatively high. Among them, 3D printed PLA stents and metal stents are easy to cause secondary stimulation to the body after clinical treatment, bringing different degrees of platelet aggregation and new thrombus. Formation, short-term cause of vascular wall restenosis, vascular wall damage and other problems; while the surface of the stent is coated with heparin, titanium oxide and other substances, or covered with a degradable or non-degradable polymer film, or smeared or added anticoagulant Drug-covered stents have the problems of low drug loading, insufficient uniformity, and rapid release of smeared drugs

[0005] Therefore, the existing 3D printed PLA vascular stents or metal vascular stents are likely to cause vascular restenosis, thrombosis, and vascular wall damage. The method of coating the stent surface with drugs has low and uneven drug loading. , the problem of excessive drug release

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