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Rimantadine hydrochloride tablet and preparation method thereof

A technology for rimantadine hydrochloride tablets and rimantadine hydrochloride, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of slow dissolution, slow absorption, disintegration, and slow dispersion. , slow onset of effect and other problems, to achieve the effect of better efficacy, lower efficacy, and better efficacy

Active Publication Date: 2020-12-15
四川省百草生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The dosage form of rimantadine hydrochloride tablet is ordinary tablet or ordinary dispersant, but because of its slow disintegration, dispersion, dissolution and absorption in the gastrointestinal tract, the onset of action is slow; or the ordinary dispersant Disintegration, but rimantadine hydrochloride is mainly absorbed in the intestinal tract, and the pH value during gastric emptying and intestinal peristalsis has a greater impact on its absorption
[0006] In summary, a rimantadine hydrochloride tablet with low cost, dispersing effect, increased drug release rate, guaranteed influenza treatment effect, and improved absorption rate of drug components and its preparation method need to be studied

Method used

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  • Rimantadine hydrochloride tablet and preparation method thereof

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Effect test

Embodiment 1

[0034] A kind of preparation method of rimantadine hydrochloride tablet, comprises the following steps:

[0035] 1) Take rimantadine hydrochloride and the carrier according to the proportioning ratio, the mass ratio of rimantadine hydrochloride and the carrier is 1:1, the carrier is hypromellose, mix the two evenly, form a mixture, and set aside;

[0036] 2) Add the mixture obtained in step 1) into a hot-melt extruder, physically and mechanically pulverize the extruded rod, and then sieve to obtain a dispersion;

[0037] 3) The dispersion obtained in step 2) is equally divided into two parts, and the filler, disintegrant and lubricant are weighed according to the proportioning ratio, and they are all divided into two parts, and one part of the dispersion is mixed with one part of the filler, disintegrant After disintegrating agent and lubricant are mixed, tabletting is made into dispersible tablet; Said batching comprises 10 parts of filler, 10 parts of disintegrating agent, 0...

Embodiment 2

[0042] A kind of preparation method of rimantadine hydrochloride tablet, comprises the following steps:

[0043] 1) Take rimantadine hydrochloride and the carrier according to the proportioning ratio, the mass ratio of rimantadine hydrochloride and the carrier is 1:2, the carrier is hypromellose, mix the two evenly, form a mixture, and set aside;

[0044] 2) Add the mixture obtained in step 1) into a hot-melt extruder, physically and mechanically pulverize the extruded rod, and then sieve to obtain a dispersion;

[0045] 3) The dispersion obtained in step 2) is equally divided into two parts, and the filler, disintegrant and lubricant are weighed according to the proportioning ratio, and they are all divided into two parts, and one part of the dispersion is mixed with one part of the filler, disintegrant After the disintegrating agent and the lubricant are mixed, the tablet is made into a dispersible tablet; the ingredients include 40 parts of filler, 30 parts of disintegrant,...

Embodiment 3

[0050] A kind of preparation method of rimantadine hydrochloride tablet, comprises the following steps:

[0051] 1) Take rimantadine hydrochloride and the carrier according to the proportioning ratio, the mass ratio of rimantadine hydrochloride and the carrier is 1:1.5, the carrier is hypromellose, mix the two evenly, form a mixture, and set aside;

[0052] 2) Add the mixture obtained in step 1) into a hot-melt extruder, physically and mechanically pulverize the extruded rod, and then sieve to obtain a dispersion;

[0053] 3) The dispersion obtained in step 2) is equally divided into two parts, and the filler, disintegrant and lubricant are weighed according to the proportioning ratio, and they are all divided into two parts, and one part of the dispersion is mixed with one part of the filler, disintegrant After disintegrating agent and lubricant are mixed, tableting is made into dispersible tablet; Said batching comprises 25 parts of fillers, 20 parts of disintegrants, 0.55 p...

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Abstract

The invention relates to the technical field of pharmaceutical engineering, and discloses a rimantadine hydrochloride tablet and a preparation method thereof, the rimantadine hydrochloride tablet comprises a dispersion and ingredients; wherein the dispersion comprises rimantadine hydrochloride and a carrier, and the ingredients comprise a filling agent, a disintegrating agent, a lubricating agentand a buffering agent; wherein the mass ratio of rimantadine hydrochloride to the carrier in the dispersion is 1: (1-2); wherein the dispersion accounts for 40-45% of the total weight of the rimantadine hydrochloride tablet; the rimantadine hydrochloride tablet prepared by the invention is added with a plurality of disintegrating agents for compounding and synergistic effect, active substances arereleased within a certain time after oral administration, and a plurality of disintegrating agent compounding systems can effectively overcome the problem that the preparation cannot be disintegrateddue to viscosity of the active ingredients when meeting water, so that the solid preparation is promoted to be disintegrated, and the released medicine is uniform and stable in speed; ensuring efficacy.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical engineering, in particular to rimantadine hydrochloride tablets and a preparation method thereof. Background technique [0002] Rimantadine Hydrochloride (Rimantadine Hydrochloride), the chemical name is: α-methyl-1-adamantylmethylamine hydrochloride, rimantadine hydrochloride antiviral drug, can inhibit virus particles from uncoating in host cells. Acts early in the viral replication cycle and is primarily active against influenza A viruses. Inhibits the proliferation of type A viruses in vitro, including H1N1, H2N2 and H3N2 subtypes isolated from humans. It has both prophylactic and therapeutic effects on animals infected with influenza A myxovirus. [0003] The existing patent CN200610124251.6 rimantadine hydrochloride tablet and its preparation method discloses a rimantadine hydrochloride tablet with high yield and low cost during preparation and its preparation method. The technical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/40A61K9/36A61K9/30A61K47/12A61K47/32A61K31/137A61P31/16
CPCA61K9/2873A61K9/286A61K9/282A61K9/284A61K9/2886A61K31/137A61P31/16Y02A50/30
Inventor 杨文朱祖全熊与丰
Owner 四川省百草生物药业有限公司
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