A preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia

A technology for dyslipidemia and composition, which is applied in the field of preparation of traditional Chinese medicine compositions, can solve the problems of patients with "phlegm and blood stasis" pathological state not significantly improved, no significant effect of prevention and control, no dredging effect, etc. , to achieve the effect of suitable market promotion and application, saving medical costs and reducing treatment costs

Active Publication Date: 2021-12-31
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, statins and fibrates are the main western medicines used clinically in Western medicine. Although these western medicines have a significant effect on improving dyslipidemia, there is no relevant description of the significant improvement in the pathological state of patients with "phlegm and blood stasis".
[0004] The existing medicines for the treatment of dyslipidemia with phlegm and blood stasis mainly include Zhibitai Capsules, Naoxintong Capsules, Yindanxinnaotong Soft Capsules and other common Chinese patent medicines. , "Red yeast rice" exerts the main effect of "activating blood circulation and removing blood stasis", but the two drugs have small blood-activating power and do not have the effect of dredging collaterals. There is no description of significant effect in the prevention and control of other complications in the next step; Naoxintong capsule focuses on "Qi deficiency and blood stasis" type cardiovascular and cerebrovascular diseases; Yindan Xinnaotong Soft Capsules focuses on "qi stagnation and blood stasis" type cardiovascular and cerebrovascular diseases. Some studies have found that it has the effect of improving hyperlipidemia, but it is not its main curative effect , and there is no significant effect description on the pathological elements of "phlegm turbidity"

Method used

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  • A preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia
  • A preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 Preparation of Qilong Xuemaijian Granules

[0067] 1) Prepare raw materials according to the following weight ratio (unit: × 10g)

[0068] Coptidis 6, frankincense 9, myrrh 9, blood jellyfish 6, pinellia 9, whole melon 15, gynostemma 15, poria cocos 30, pangosaurus 15, among which frankincense is fried frankincense with vinegar; myrrh is myrrh fried with vinegar;

[0069] 2) Wash the raw materials Coptis chinensis, frankincense, myrrh, Pinellia, Trichosanthes, Gynostemma, Poria cocos, and pangosaurus, put them in a Chinese medicine multifunctional extraction kettle and mix well, add tap water to soak for 30 minutes (usually 20-90 minutes), Wherein, the ratio of the weight of tap water added to the weight (dry weight) of the medicinal material mixture is 9:1 (usually 1-15:1);

[0070] 3) Turn on the power supply of the multifunctional extraction kettle for heating, heat to 100°C, keep at this temperature for constant temperature extraction for 3 hours, and the...

Embodiment 2

[0079] Preparation of Example 2 Qilong Xuemaijian Pills

[0080] 1) Prepare raw materials according to the following weight ratio (unit: × 10g)

[0081] Coptis 3, frankincense 6, myrrh 9, blood jellyfish 9, pinellia 6, whole melon 15, gynostemma 15, poria cocos 30, pangosaurus 30

[0082] 2) After rinsing the medicinal materials Coptis chinensis, frankincense, myrrh, Pinellia, Gualou, Gynostemma pentaphyllum, Poria cocos, and pangosaurus, they were placed in a multifunctional extraction kettle of traditional Chinese medicine and mixed evenly, and then soaked in tap water for 60 minutes. The weight of the added tap water was equal to The weight (dry weight) ratio of the medicinal material mixture is 6:1;

[0083] 3) Turn on the power supply of the multi-functional extraction kettle for heating, heat to 80°C, keep at this temperature for constant temperature extraction for 5 hours, and then filter to obtain the first extraction solution for use;

[0084] 4) Then add tap water ...

Embodiment 3

[0089] Preparation of Example 3 Qilong Xuemaijian Tablets

[0090] 1) Prepare raw materials according to the following weight ratio (unit: × 10g)

[0091] Coptidis 9, frankincense 9, myrrh 6, blood dried fruit 3, pinellia 9, whole melon 9, gynostemma 30, poria cocos 15, pangosaurus 10

[0092] 2) Wash the raw materials Coptis chinensis, frankincense, myrrh, Trichosanthes, Gynostemma, Poria cocos, and mountain dragon, put them in a multi-functional extraction kettle of traditional Chinese medicine, add tap water to soak for 20 minutes (usually 20-90 minutes), wherein, the added tap water The ratio of the weight to the weight of the medicinal material mixture (dry weight) is 12:1 (usually 1-15:1);

[0093] 3) Turn on the power supply of the multifunctional extraction kettle for heating, heat to 80°C, keep at this temperature for constant temperature extraction for 5 hours, and then filter to obtain the first extraction solution for use;

[0094] 4) Then add tap water to the fi...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine composition for preventing and / or treating dyslipidemia, which comprises firstly mixing Coptidis Rhizoma, Frankincense, Myrrha, Pinellia, Trichosanthes, Jiaogulan, Poria, and Cyclopsia chinensis with water, then heating and extracting, and concentrating the extract; crushing the dried blood into powder; then mixing the concentrated extract with the dried blood. The method for preparing the traditional Chinese medicine composition for treating dyslipidemia of the present invention is simple in process, the preparation process conditions are mild, and the drug effect of the crude drug is retained to the greatest extent. The traditional Chinese medicine composition prepared by the method of the present invention is suitable for the situation of dyslipidemia, especially high For blood lipid symptoms, it can be prepared into any commonly used oral dosage form and health care product. It has the effects of resolving phlegm and promoting blood circulation, reducing turbidity and dredging collaterals, improving blood lipid abnormalities, and achieving the purpose of significantly reducing blood lipids. It is especially suitable for blood lipids with mixed phlegm and blood stasis. Abnormal application; the preparation method of the present invention is easy to operate, not only environmentally friendly, but also reduces production costs and improves economic benefits.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition, in particular to a preparation method of a traditional Chinese medicine composition for treating dyslipidemia, and belongs to the field of traditional Chinese medicine. Background technique [0002] The disordered state of blood lipids can create an environment for the occurrence and development of atherosclerosis. Hyperlipidemia in adulthood increases the subsequent risk of coronary heart disease in a dose-dependent manner, and adults with long-term exposure to non-high-density lipoprotein cholesterol may increase the risk of future coronary heart disease. Multiple clinical trials of lipid-lowering drugs and epidemiological studies have also confirmed the relationship between serum cholesterol levels and the risk of coronary heart disease. At the same time, hyperlipidemia is also an important condition for the birth of diseases such as diabetes and periodonti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61K36/896A61P3/06
CPCA61K36/718A61K36/324A61K36/328A61K36/8888A61K36/428A61K36/424A61K36/076A61K36/8945A61K36/889A61K36/896A61P3/06A61K2300/00
Inventor 胡元会崔翰明师帅张秋燕杜柏褚瑜光王欢邱志凌
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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