Medical composite nanofiber dressing as well as preparation method and application thereof

Abstract

The invention relates to a medical composite nanofiber dressing and a preparation method thereof. The dressing is divided into an inner layer and an outer layer, the inner layer contains polyvinyl alcohol, collagen and quaternized chitosan, the outer layer contains polycaprolactone and dodecyl substituted quaternized silicone, the polyvinyl alcohol, collagen and quaternized chitosan are mixed, aninner layer PCQC5 is prepared through an electrostatic spinning method, the polycaprolactone and dodecyl-substituted quaternized silicone QP12 are used as raw materials, and an outer layer is preparedthrough an electrostatic spinning method on the basis of the inner layer PCQC5. The dressing can be used for tissue repair or scar repair, and has wide application in the field of antibacterial materials or medical instruments.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a medical composite nanofiber dressing with functions of hemostasis, antibacterial and anti-inflammation, wound repair and scar repair, as well as its preparation method and application. Background technique [0002] Trauma and postoperative hemostasis, infection prevention and scar treatment have always been the key and difficult problems that need to be solved urgently in clinic. Due to the long time of trauma and postoperative wound repair, poor healing caused by complex conditions, and even complications such as severe infection, sepsis, and ulcer canceration, may endanger the lives of patients. [0003] Wound healing is the body's repair response to skin tissue defects. Normal skin wound healing is characterized by four distinct but overlapping phases, hemostatic, inflammatory, proliferative, and remodeling. When the four stages of wound healing are interrupted, ...

AI Technical Summary

Problems solved by technology

Medical materials can play a role in repairing chronic refractory wounds. At present, there are 2,400 kinds of wound dressings in the domestic and foreign markets, but all of them have problems such as single function and susceptibility to infection.

According to the "Practical Handbook on the Prevention and Control of Nosocomial Infections" issued by the World Health Organization (WHO), 60% of global clinical infections are related to the use of medical devices. In order to deal with infections caused by medical devices and implants, antibiotic systems are currently used clinically. treatment, but there are significant adverse reactions, allergic reactions and drug resistance

Clinically, functional materials with antibacterial properties have become the best choice. However, medical devices such as wound dressings currently used in clinical practice either have insufficient antibacterial activity or single functions, resulting in a series of problems such as frequent wound infection and poor wound and scar repair effects.

Images