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Application of Tanreqing in preparation of drugs for treating novel coronavirus pneumonia

A coronavirus and tanreqing technology, which is applied in the field of preparation of medicines for the treatment of novel coronavirus pneumonia, and achieves the effects of shortening the antipyretic time, improving cough symptoms, and shortening the coughing time.

Pending Publication Date: 2020-11-06
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Novel coronavirus pneumonia infection pneumonia is a new disease, and there is no targeted vaccine and specific medicine. Therefore, we are developing Tanreqing, which is composed of five medicinal materials including skullcap, bear bile powder, goat horn, honeysuckle, and forsythia. Application research on drugs for coronavirus pneumonia

Method used

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  • Application of Tanreqing in preparation of drugs for treating novel coronavirus pneumonia
  • Application of Tanreqing in preparation of drugs for treating novel coronavirus pneumonia
  • Application of Tanreqing in preparation of drugs for treating novel coronavirus pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 : Clinical research results of Tanreqing Capsules in the treatment of novel coronavirus pneumonia

[0028] With conventional treatment as the control, a parallel randomized, open, single-center clinical trial design is adopted:

[0029] ①Using block randomization method. Using professional statistical software, a random table of treatment (experimental group and control group) received by 72 subjects in two groups was generated, that is, the treatment allocation table corresponding to the serial number 001-072. And produce 72 random allocation letters according to the content of the random table, and the content of each letter is the group and treatment plan corresponding to each random number. After the subjects were enrolled, they opened the corresponding distribution letters in ascending order, and adopted the treatment plan shown in the letters.

[0030] ② This trial is an exploratory trial to initially evaluate the clinical effectiveness and safety of...

Embodiment 2

[0061] Example 2 : Clinical research results of Tanreqing injection in the treatment of novel coronavirus pneumonia

[0062] 1. Body temperature recovery time

[0063] Comparing the temperature recovery time between the control group and the treatment group, 3 people in the control group had no fever at the baseline level, and 4 people in the treatment group had no fever at the baseline level. The average antipyretic of the control group was 2.76 days, the median was 2 (1, 2) days, the average antipyretic of the test group was 1.68 days, the median was 3 (2, 4) days, the difference was statistically significant (P<0.01 ), suggesting that the use of Tanreqing injection in the treatment of patients with new coronary pneumonia can shorten the time for body temperature to return to normal by 1.08 days. See Table 5.

[0064] Table 5 The average time for body temperature recovery in the two groups of patients

[0065]

[0066] 2Comparison of days of hospitalization between t...

Embodiment 3

[0071] Example 3 : Mechanism of Tanreqing Capsules in the Treatment of Novel Coronavirus Pneumonia Based on Network Pharmacology

[0072] Tanreqing Capsules are made by extracting 5 medicinal materials including Scutellaria baicalensis, bear bile powder, goat horn, honeysuckle, and forsythia. On the one hand, 19 compounds of flavonoids, lignans, phenylethanol glycosides, organic acids, amino acids, and bile acids from five medicinal materials were selected as research objects, and 19 compounds were drawn using ChemBio Office 2010 The structure of scutellarin, baicalin, scutellarin-7-O-glucuronide, chrysin-7-O-glucuronide, forsythin, forsythiaside E, forsythia Esteroside D, chlorogenic acid, caffeic acid, isochlorogenic acid A, glycine, alanine, arginine, lysine, valine, tyrosine, leucine, ursodeoxycholic acid and cheese deoxycholic acid.

[0073] Through reverse docking experiments on the Swiss Target Prediction server and TCMSP database retrieval, a total of 163 related t...

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Abstract

The invention relates to an application of Tanreqing in the preparation of drugs for treating novel coronavirus pneumonia. The application of Tanreqing in the preparation of drugs for treating novel coronavirus pneumonia of the invention can shorten the virus nucleic acid negative conversion time of patients with novel coronavirus pneumonia, can shorten the fever abatement time of the patients with novel coronavirus pneumonia, can shorten the cough time of the patients with novel coronavirus pneumonia, can improve the cough symptom of the patients with novel coronavirus pneumonia, and can improve the finger blood oxygen saturation of the patients with novel coronavirus pneumonia.

Description

technical field [0001] The present invention relates, in particular, to the application of Tanreqing in the preparation of medicines for treating novel coronavirus pneumonia. Background technique [0002] Novel coronavirus pneumonia infection pneumonia is a new disease, and there is no targeted vaccine and specific medicine. Therefore, we are developing Tanreqing, which is composed of five medicinal materials including scutellaria baicalensis, bear bile powder, goat horn, honeysuckle, and forsythia. Applied research on drugs for coronavirus pneumonia. Contents of the invention [0003] The purpose of the present invention is to address the deficiencies in the prior art and provide the application of Tanreqing in the preparation of drugs for the treatment of novel coronavirus pneumonia. [0004] For realizing above-mentioned object, the technical scheme that the present invention takes is: [0005] The invention provides the application of Tanreqing in the preparation of ...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61P11/00A61P11/14A61P29/00A61P31/14A61K35/32A61K35/413
CPCA61K35/32A61K35/413A61K36/355A61K36/539A61K36/634A61P11/00A61P11/14A61P29/00A61P31/14A61K2300/00
Inventor 张小利穆竟伟刘绍勇杜学航
Owner SHANGHAI KAIBAO PHARMA
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