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Near-infrared long-afterglow luminescent material excited by biological window and preparation method thereof

A technology of luminescent materials and external length, applied in luminescent materials, photodynamic therapy, chemical instruments and methods, etc., can solve the problems of short excitation light wavelength, limited biological imaging time and its sensitivity, and achieve strong afterglow intensity and Rayleigh scattering effect Small, low phototoxic effect

Active Publication Date: 2020-09-18
厦门大学附属心血管病医院
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Problems solved by technology

[0003]However, the near-infrared long-lasting luminescent materials reported so far have a relatively short excitation wavelength (mostly located in the ultraviolet region), so the materials can only be pre-excited in vitro , followed by bioimaging
After the near-infrared long-lasting luminescence decays, it is difficult for this short-wavelength ultraviolet light to re-excite the materials in the body through living tissues, which greatly limits the biological imaging time and sensitivity of near-infrared long-lasting luminescent materials.

Method used

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  • Near-infrared long-afterglow luminescent material excited by biological window and preparation method thereof
  • Near-infrared long-afterglow luminescent material excited by biological window and preparation method thereof
  • Near-infrared long-afterglow luminescent material excited by biological window and preparation method thereof

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preparation example Construction

[0023] refer to Figure 5 As shown, the embodiment of the present invention also provides a preparation method of a near-infrared long-lasting luminescent material excited by a biological window, comprising the following steps:

[0024] S1, according to the chemical formula Zn 1+x Ga 2-2x sn x o 4 :Cr y , Y z In the stoichiometric ratio, weigh the corresponding mass of Zn-containing compound, Ga-containing compound, Sn-containing compound, Cr-containing compound and Y-containing compound, mix the above compounds, and then grind them evenly to obtain a mixture. Since the degree of mixing of the reactants has a great influence on the uniformity and adequacy of the reaction, the degree of mixing of the reactants can be increased by grinding, so that the reactants can fully contact each other, thereby increasing the uniformity of the reaction between the raw materials and sufficiency.

[0025] Further, the Zn-containing compound is zinc oxide, zinc carbonate, zinc nitrate o...

Embodiment 1

[0034] A near-infrared long-lasting luminescent material excited by a biological window provided in this embodiment has a molecular formula of Zn 1.1 Ga 1.8 sn 0.1 o4 :Cr 0.005 , which is prepared as follows:

[0035] S1, according to the chemical formula Zn 1.1 Ga 1.8 sn 0.1 o 4 :Cr 0.005 The stoichiometric ratio shown in , respectively weighed the corresponding mass of ZnO, Ga 2 o 3 , SnO 2 and Cr 2 o 3 , mix the above compounds, and then grind them uniformly to obtain a mixture.

[0036] S2. Calcining the mixture at 1350° C. for 5 hours and cooling to room temperature to obtain a near-infrared long-lasting luminescent material excited by a biological window.

[0037] refer to figure 1 As shown, the diffraction pattern is consistent with that of ZnGa 2 o 4 The standard diffraction pattern (JCPDS086-0413) is consistent, indicating that the synthesized sample is a pure cubic phase structure, and its chemical stability is good.

[0038] refer to figure 2 and ...

Embodiment 2

[0040] A near-infrared long-lasting luminescent material excited by a biological window provided in this embodiment has a molecular formula of Zn 1.2 Ga 1.6 sn 0.2 o 4 :Cr 0.005 , which differs from the preparation method in Example 1 in that:

[0041] In step S1, according to the chemical formula Zn 1.2 Ga 1.6 sn 0.2 o 4 :Cr 0.005 The stoichiometric ratio shown in , respectively weighed the corresponding mass of ZnO, Ga 2 o 3 , SnO 2 and Cr 2 o 3 , mix the above compounds, and then grind them uniformly to obtain a mixture.

[0042] The excitation light of the near-infrared long-lasting luminescent material in this embodiment is located in the biological imaging window, and the wavelength of the excitation light is greater than 650nm. The luminescence peak of the near-infrared long-lasting luminescent material excited by the biological window is located at 696nm, and its long-lasting luminescence time far exceeds 1 hour. The near-infrared long-afterglow luminesc...

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Abstract

The invention provides a near-infrared long-afterglow luminescent material excited by a biological window and a preparation method of the near-infrared long-afterglow luminescent material. The chemical structural formula of the near-infrared long-afterglow luminescent material is Zn1+xGa2-2xSnxO4: Cry, Yz, wherein x is larger than 0 and smaller than or equal to 0.5, y is larger than 0 and smallerthan 0.01, and z is larger than or equal to 0 and smaller than 0.01. Exciting light of the near-infrared long-afterglow luminescent material is located in a biological imaging window, and the wavelength of the exciting light is larger than 650 nm. The luminescent peak value is about 696nm, the long afterglow luminescent time is far longer than 1 hour, the afterglow intensity is high, the afterglowtime is long, and the material can be applied to the fields of photodynamic therapy, biological imaging and the like. In addition, the invention further relates to a preparation method of the near-infrared long-afterglow luminescent material excited by the biological window. The raw materials are wide in source and low in price. In the operation process, only all the compounds need to be mixed, ground and calcined, protective atmosphere is not needed, operation is easy, and the method is suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of luminescent materials, and in particular to a near-infrared long-lasting luminescent material excited by a biological window and a preparation method thereof. Background technique [0002] Near-infrared long-lasting luminescent material is a new type of bioluminescent material, which has potential application prospects in the field of biomedicine. The near-infrared long-lasting luminescent material can store part of the energy after absorbing the excitation light energy. After the excitation light stops exciting, the stored energy will be released slowly in the form of luminescence. This phenomenon of continuous luminescence is called long afterglow. Utilizing the near-infrared long afterglow luminescence properties, background-free biological imaging can be realized, which greatly improves the sensitivity of biological imaging. [0003] However, the currently reported near-infrared long-lasting lumines...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/66A61K49/00A61K41/00
CPCC09K11/7708A61K49/0019A61K41/0057
Inventor 孙霞史俊朋
Owner 厦门大学附属心血管病医院
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