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Surface grafted curcumin modified degradable polyurethane composite material as well as preparation method and application thereof

A polyurethane material and surface grafting technology are applied in the field of surface grafting curcumin-modified degradable polyurethane composite materials and their preparation fields, which can solve the problems of single additional properties and the like, and achieve stable fluorescence, mechanical properties and thermal stability improvement. , good antibacterial and biocompatibility effects

Active Publication Date: 2020-09-18
SHANDONG NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Patent CN109575233A discloses a hyperbranched polyester modified polyurethane medical interventional catheter and its preparation method. This patent utilizes the characteristics of hyperbranched polyester with a large number of end groups, combined with the grafting of chemical bonds between the catheter and the coating, excellent Lubricant and wear-resistant polyurethane medical interventional catheters, the catheters prepared by this method are only improved in physical properties, and can be suitable for use in the field of endovascular interventional diagnosis and treatment, but the additional properties are relatively single

Method used

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  • Surface grafted curcumin modified degradable polyurethane composite material as well as preparation method and application thereof
  • Surface grafted curcumin modified degradable polyurethane composite material as well as preparation method and application thereof
  • Surface grafted curcumin modified degradable polyurethane composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Take 0.5mL hexamethylene diisocyanate (HDI) and add it to 10mL anhydrous toluene, put 1×1cm 2 After the modified polyurethane material is washed with anhydrous toluene until the surface is clean, it is put into the mixed solution of anhydrous toluene and hexamethylene diisocyanate (HDI), and 1-2 drops of the catalyst dibutyltin dilaurate are added dropwise. Shake the reaction at ℃ for 2 hours. After the completion, take out the membrane and wash it repeatedly to remove unreacted HDI, and prepare a membrane (PU-NCO) grafted with isocyanate on the surface of polyurethane;

[0058] (2) Dissolve 0.368g curcumin in 10mL of anhydrous toluene solution, then mix the PEU-NCO membrane prepared in step (1) with the above solution, stir and react at 45°C for 16h, and then use anhydrous toluene Rinse (measure the washing liquid), and then rinse with ethanol, and put it into a vacuum drying oven to dry for 24 hours to prepare a degradable polyurethane film modified by grafting cu...

Embodiment 2

[0064] (1) 0.368g of curcumin, 0.2g of 2-(-4-isobutylphenyl)propionic acid (ibuprofen), 0.2g of 1-ethyl-(3-dimethylaminopropyl ) carbodiimide hydrochloride (EDC.HCL), 0.12g of 4-dimethylaminopyridine (DMAP) were added to 15mL of dichloromethane and mixed respectively, stirred and reacted at 25°C for 1.5h, and cooled with NaHCO 3 Extracted from dichloromethane, then subjected to Na 2 SO 4 Drying, concentration under reduced pressure, purification by silica gel chromatography, and drying to obtain the pure product modified curcumin;

[0065] (2) Take 0.5mL hexamethylene diisocyanate (HDI) and add it to 10mL anhydrous toluene, put 1×1cm 2 After the modified polyurethane material is washed with anhydrous toluene until the surface is clean, it is put into the mixed solution of anhydrous toluene and hexamethylene diisocyanate (HDI), and 1-2 drops of the catalyst dibutyltin dilaurate are added dropwise. Shake the reaction at ℃ for 2 hours. After the completion, take out the membr...

Embodiment 3

[0069] (1) 0.552g of curcumin, 0.4g of 2-(-4-isobutylphenyl)propionic acid (ibuprofen), 0.4g of 1-ethyl-(3-dimethylaminopropyl ) carbodiimide hydrochloride (EDC.HCL), 0.24g of 4-dimethylaminopyridine (DMAP) were added to 20mL of dichloromethane and mixed respectively, stirred and reacted at 25°C for 2h, and cooled with NaHCO 3 Extracted from dichloromethane, then subjected to Na 2 SO 4 Drying, concentration under reduced pressure, purification by silica gel chromatography, and drying to obtain the pure product modified curcumin;

[0070] (2) Take 0.8mL hexamethylene diisocyanate (HDI) and add it to 15mL anhydrous toluene, put 1×1cm 2 After the modified polyurethane material is washed with anhydrous toluene until the surface is clean, put it into the mixed solution of anhydrous toluene and hexamethylene diisocyanate (HDI), add 1-2 drops of catalyst DBTDL, and shake it at 45°C for 4 hours. After the completion, take out the membrane and wash it repeatedly to remove unreacted ...

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PUM

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Abstract

The invention relates to a surface grafted curcumin modified degradable polyurethane composite material as well as a preparation method and application thereof. The polyurethane material is composed of polyurethane and modified curcumin grafted with polyurethane, the polyurethane is connected with the modified curcumin through -CONH- chemical bonds, and the polyurethane material is a polyurethanematerial with a carbamate structure in the molecular formula. The chemical structural formula of the modified curcumin is represented by a formula II, wherein R is C3-C4 straight-chain or branched-chain alkyl.

Description

technical field [0001] The invention belongs to the technical field of polyurethane polymer materials, and in particular relates to a surface-grafted curcumin-modified degradable polyurethane composite material and a preparation method and application thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Polyurethane is a polymer material containing carbamate (-NHCOO-) repeating units in the main chain, referred to as PU. Due to the large differences in the thermodynamic and polar properties of each chain segment in the PU macromolecule, it will cause the microphase separation of the PU aggregate structure, which makes it have excellent mechanical properties, mechanica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08L75/04
CPCC08J7/12C08J2375/04
Inventor 邹超侯昭升景臣祝敬妥钟文滕金伟徐钧刘辉王赛
Owner SHANDONG NORMAL UNIV
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