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A kind of method for adjusting polyglycolic acid molecular chain structure

A polyglycolic acid and molecular chain technology, applied in the field of molecular chain regulation, can solve problems such as slow degradation rate, difficulty in obtaining transparent molded products, and difficulty in amorphous preformed products, etc. Hydrolysis performance, effect of improving heat resistance

Active Publication Date: 2022-08-02
PUJING CHEM IND SHA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Compared with other biodegradable polymer materials such as aliphatic polyesters, polyglycolic acid has obvious advantages in heat resistance, barrier properties, and mechanical properties, but its application is still limited by three aspects compared with other polymer materials: One is that it is difficult to obtain high-molecular-weight products and the melt strength is not ideal, so it is difficult to apply to products with high strength requirements. Second, polyglycolic acid can meet the requirements for the strength of commonly used plastic products, but the degradation rate is still not very good. Fast, and the third is that polyglycolic acid crystallizes very quickly. When extruded into sheets, films, fibers, etc., it is easy to crystallize when cooled from a molten state, and it is not easy to obtain amorphous preforms, so it is difficult to obtain transparent moldings. Therefore, when melt processing crystalline polyglycolic acid, the molding temperature, processing temperature, melting temperature, etc. are limited to a narrow range.

Method used

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  • A kind of method for adjusting polyglycolic acid molecular chain structure
  • A kind of method for adjusting polyglycolic acid molecular chain structure
  • A kind of method for adjusting polyglycolic acid molecular chain structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Preparation of polyglycolic acid polymer with anti-hydrolysis and anti-oxidation properties: under the atmosphere of normal temperature and pressure and nitrogen protection, add 100g of glycolide monomer, 100ppm of isopropanol, 20ppm of linear stannate, open and stir, from 80 The temperature rises at ℃ and the reaction time is 100min. SAG (epoxy polymer) is added 5min before the end of the reaction, preferably in the form of a liquid to facilitate dispersion.

[0064] figure 1 By adding different amounts of SAG epoxy polymer, the final product molecular weight and material fluidity change. It can be seen from the figure that the molecular weight will increase when the addition amount is from 0 to 1%, and the melt index will become smaller at the same time. The reaction between the epoxy polymer and the chain end leads to a slight increase in its molecular weight and is affected by the end-capping effect of the polyester. The anti-oxidation performance has improved, and...

Embodiment 2

[0069] Preparation of polyglycolic acid polymer with increased molecular weight: under the atmosphere of normal temperature and pressure and nitrogen protection, add 100g of glycolide monomer, 100ppm of isopropanol, 12ppm of linear stannate, turn on and stir, and start the heating reaction from 80°C After reaching the reaction temperature, PEG with different molecular weights and Wt accounting for 5% was added to react, and the reaction was continued for 50 min after reaching the reaction temperature.

[0070] Table 2

[0071]

[0072] As can be seen from the above table, the molecular weight changes when 5% of PEG with different molecular weights are added. When PEG with a molecular weight of 6000 is added, the molecular weight of the polyester obtained increases by 3w compared with the pure material, and the intrinsic viscosity also increases accordingly.

Embodiment 3

[0074] Preparation of non-crystalline polyglycolide: under the atmosphere of normal temperature and pressure and nitrogen protection, add 100g glycolide monomer, 82.5g lactide monomer, 100ppm isopropanol, 12ppm linear stannate, turn on and stir , start the heating reaction from 80℃, and react for 6 hours after reaching the target temperature, then devolatilize and then cool and granulate. The obtained sample is light yellow transparent crystal, the weight average molecular weight is 15×104, the intrinsic viscosity is 1.21dL / g, the tensile strength of polyglycolic acid is 100Mpa, the elongation is 3.15%, and the tensile strength of polyglycolide is 78Mpa, the elongation is 300%.

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Abstract

The invention relates to a method for adjusting the molecular chain structure of polyglycolic acid. Under the protection of normal temperature, normal pressure and inert gas, glycolide, initiator, lactide, hydroxylated (amide) monomer or hydroxylated polymer The product or comonomer and catalyst are sequentially added into the reactor, heated and stirred to carry out the polymerization reaction, and after the reaction is completed, the product is post-treated and dried to obtain the polyglycolic acid whose molecular chain structure is adjusted. The present invention changes the molecular structure by adding some functional groups (hydrophilic and hydrophobic groups -OH, -COOR, etc.) or segments (branching, copolymerization, etc.) with special performance characteristics, so as to change the original polyglycolic acid. Molecular properties (molecular weight, viscosity, melt index, hydrolyzability, crystallinity, processability, etc.).

Description

technical field [0001] The present invention relates to a method for regulating molecular chain, in particular to a method for regulating the structure of polyglycolic acid molecular chain. Background technique [0002] It is known that the polyglycolic acid molecular chain contains aliphatic ester bonds, which are hydrolyzed under the promotion of enzymes or acids and alkalis in microorganisms or organisms, and finally form carbon dioxide and water. In recent years, with the increase of plastic products, plastic waste is The treatment of ethylene glycol has become a problem that cannot be ignored. As a degradable bio-based material with less impact on the environment, polyglycolic acid has received extensive attention. [0003] Polyglycolic acid has good tissue compatibility and is widely used in medical and surgical sutures, internal fixation of fractures, tissue engineering repair materials and drug controlled release and other medical polymer materials (US Patent No. 3,2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/08C08G63/664C08G63/64C08G18/42
CPCC08G63/08C08G63/664C08G63/64C08G18/428
Inventor 王赛博
Owner PUJING CHEM IND SHA
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