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Silk fibroin/functionalized polytrimethylene carbonate hydrogel for repairing endometrium and preparation method

A methyl carbonate and silk fibroin technology, which is applied in the field of biomedical materials and regenerative medicine, can solve the problems of long gelation time of silk fibroin hydrogel and reduce the activity of loaded cells, and the gelation time can be reached. control, improve biocompatibility, and the effect of abundant raw material resources

Active Publication Date: 2020-09-08
杨立群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a silk fibroin / functionalized polytrimethylene carbonate hydrogel for repairing the endometrium and its preparation method, which solves the problem that the gelation time of the silk fibroin hydrogel is too long, and significantly Improve the defects of polyester blends, ensure that the hydrogel does not produce acidic degradation products during the degradation process, always maintain the good biocompatibility of silk fibroin, do not reduce the activity of loaded cells, and repair the endometrium, etc. The field of biomedicine has broad application prospects

Method used

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  • Silk fibroin/functionalized polytrimethylene carbonate hydrogel for repairing endometrium and preparation method
  • Silk fibroin/functionalized polytrimethylene carbonate hydrogel for repairing endometrium and preparation method
  • Silk fibroin/functionalized polytrimethylene carbonate hydrogel for repairing endometrium and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] In this example, the preparation method of the silk fibroin / functionalized polytrimethylene carbonate hydrogel for repairing the endometrium is as follows:

[0038] (1) Use trimethylolethane as a raw material to obtain oxetane through transesterification and pyrolysis decarboxylation; add 1.8 L of polyethylene glycol ether (m=3) and a few drops of concentrated sulfuric acid to the reaction flask in sequence (0.5 mL), the temperature was raised to 135° C. under stirring, and 400 mL of a solution of 102 g of oxetane in polyethylene glycol ether (m=3) was slowly added dropwise. After dropping, keep warm for 6 hours. Cool to room temperature, recover excess polyglycol ether (m=3) under reduced pressure, and distill under reduced pressure to obtain 168.5 g of colorless liquid.

[0039] (2) Add 133g of the colorless liquid prepared in step (1), 20mL of pyridine and 1.5L of anhydrous tetrahydrofuran (THF) to the reaction flask in sequence, stir to dissolve; warm up to 60°C, s...

Embodiment 2

[0051] The difference from Example 1 is: the polyethylene glycol ether (m=4) used in step (1), and other conditions are the same as in Example 1.

Embodiment 3

[0053] The difference from Example 2 lies in that: PEG (n=113) is used in step (3), and the molar ratio of PEG to EOTMC is 1:20, and other conditions are the same as in Example 2.

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Abstract

The invention belongs to the field of biomedical materials and regenerative medicine, and particularly relates to silk fibroin / functionalized polytrimethylene carbonate hydrogel for repairing endometrium and a preparation method. The hydrogel comprises silk fibroin, functionalized polytrimethylene carbonate and living cells, wherein the mass ratio of the silk fibroin to the functionalized polytrimethylene carbonate is (5-1):1. According to the invention, the biocompatibility of the hydrogel is improved by introducing the functionalized polytrimethylene carbonate which contains a hydrophilic chain segment, does not contain any ester bond, does not generate an acidic degradation product in a degradation process and has controllable and adjustable performance; and the gelling time and the gelling mode of the silk fibroin hydrogel are regulated and controlled through the structure, composition, content and other factors of the functionalized polytrimethylene carbonate, and cells / stem cellsare loaded at the same time, so that the hydrogel has no side effect on the loaded cells and has no irritation to an implanted part, and the purpose of repairing endometrium is achieved.

Description

technical field [0001] The invention belongs to the field of biomedical materials and regenerative medicine, and in particular relates to a silk fibroin / functionalized polytrimethylene carbonate hydrogel for repairing endometrium and a preparation method thereof. Background technique [0002] Infertility has become the third serious disease after cancer and cardiovascular disease, which poses a major threat to human reproduction and is one of the important social problems faced by countries all over the world. At present, endometrial injury has become one of the main causes of female secondary infertility. How to improve the effect of comprehensive treatment and improve the pregnancy rate of patients has become the focus of endometrial repair. Since the 21st century, tissue engineering and regenerative medicine have become important treatments for improving the health of the body. Stem cells have received extensive attention in the fields of tissue engineering and regenerat...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/58A61L27/50A61L27/22A61L27/18A61L27/38C08J3/075C08G64/18C08G64/30C08L89/00C08L69/00
CPCA61L27/18A61L27/227A61L27/3834A61L27/3839A61L27/50A61L27/52A61L27/58C08G64/183C08G64/305C08J3/075C08J2389/00C08J2469/00C08L69/00
Inventor 杨立群
Owner 杨立群
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