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Preparation method of grape seed procyanidine sustained-release microcapsules

A slow-release microcapsule and proanthocyanidin technology, which is applied in the direction of microcapsule preparation, microsphere preparation, food forming, etc., can solve the problems of no slow-release effect, easy oxidative denaturation, and short action time, so as to improve the embedding rate, Improved stability and simple operation steps

Pending Publication Date: 2020-08-21
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This grape seed proanthocyanidin capsule preparation has no sustained-release effect, and the grape seed proanthocyanidin is released quickly after oral administration, and the action time is short. In addition, the grape seed proanthocyanidin is active in nature, and its phenolic hydroxyl group is easily oxidized and denatured under external environmental conditions such as oxygen, moisture, and pH.

Method used

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  • Preparation method of grape seed procyanidine sustained-release microcapsules

Examples

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Embodiment 1

[0032] A preparation method of grape seed proanthocyanidin sustained-release microcapsules, comprising the steps of:

[0033] S1. Add sodium alginate into water, stir at 600 rpm until the sodium alginate is dissolved, and obtain a 0.5% aqueous solution of sodium alginate;

[0034] S2. Take hydroxypropyl methylcellulose and add it into water to soak for 1 hour, and heat to the hydroxypropyl methylcellulose solution at 60° C. to obtain a 0.2% aqueous solution of hydroxypropyl methylcellulose;

[0035] S3. Stir and mix 0.5% sodium alginate solution and 0.2% hydroxypropyl methylcellulose solution according to the volume ratio of 1:1 to obtain a sodium alginate-hydroxypropyl methylcellulose mixed solution;

[0036] S4. Add grape seed proanthocyanidins into water, stir and mix at 600 rpm to obtain a 25 mg / mL grape seed proanthocyanidin solution;

[0037] S5. Take 1 mL of 25 mg / mL grape seed proanthocyanidin solution and add it to the sodium alginate-hydroxypropyl methylcellulose mi...

Embodiment 2

[0040] A preparation method of grape seed proanthocyanidin sustained-release microcapsules, comprising the steps of:

[0041] S1. Take sodium alginate and add it to water, stir at 600 rpm until the sodium alginate is dissolved, and obtain a 1% aqueous solution of sodium alginate;

[0042] S2, taking hydroxypropyl methylcellulose and soaking in water for 1 hour, heating to the hydroxypropyl methylcellulose solution at 60° C. to obtain a 0.4% aqueous solution of hydroxypropyl methylcellulose;

[0043] S3. Stir and mix 1% sodium alginate solution and 0.4% hydroxypropyl methylcellulose solution according to the volume ratio of 1:1 to obtain a sodium alginate-hydroxypropyl methylcellulose mixed solution;

[0044] S4. Add grape seed proanthocyanidins into water, stir and mix at 600rpm to obtain a 50mg / mL grape seed proanthocyanidin solution;

[0045] S5. Take 1 mL of 50 mg / mL grape seed proanthocyanidin solution and add it to the sodium alginate-hydroxypropyl methylcellulose mixtur...

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Abstract

The invention provides a preparation method of grape seed procyanidine sustained-release microcapsules, which comprises the following steps: uniformly mixing a sodium alginate water solution and a hydroxypropyl methyl cellulose water solution to obtain a mixed solution; uniformly mixing the grape seed procyanidine aqueous solution with the mixed solution to obtain a sodium alginate-hydroxypropyl methyl cellulose-grape seed procyanidine mixed solution; and injecting the solution into the microcapsule stationary liquid to obtain the grape seed procyanidine sustained-release microcapsule. According to the preparation method, grape seed procyanidine is used as a core material, and the grape seed procyanidine is embedded by utilizing the characteristic that sodium alginate is in contact with calcium ions and can be instantaneously gelatinized; the operation steps are simple without adding an organic solvent; by utilizing the characteristic of pH sensitivity of hydroxypropyl methyl cellulose, the stability and embedding rate of the microcapsule are improved, and the release speed of the embedded grape seed procyanidine can be adjusted; and the prepared grape seed procyanidine sustained-release microcapsule can be applied to the fields of health-care products and functional foods.

Description

technical field [0001] The invention relates to the technical field of microcapsule preparation, in particular to a preparation method of grape seed proanthocyanidin slow-release microcapsules. Background technique [0002] Grape seed proanthocyanidins are extremely unstable and will be affected by light, pH value, temperature and other conditions. These factors are inevitable during its storage. [0003] Hydroxypropyl methylcellulose is a high molecular polymer obtained by modifying cellulose. It has good mechanical properties, chemical stability and water vapor resistance, and is a good material for preparing microcapsules. [0004] Microcapsule is to embed solid, liquid or gaseous substances in the wall material in a certain way to form a microcapsule product, which has the characteristics of protecting the core material, isolating the active ingredient and controlling its continuous release, and extending the storage period. [0005] Most of the existing oral proanthocy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L29/256A23L29/262A23P10/30B01J13/02
CPCA23L33/105A23L29/256A23L29/262A23P10/30B01J13/02
Inventor 盛康亮王永中张光辉汪静敏孔小卫
Owner ANHUI UNIVERSITY
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