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Microneedle drug release device and manufacturing method, skin disease treatment device

A manufacturing method and microneedle technology, applied in the field of biomedicine, can solve the problems of difficulty in controlling the release speed of the drug and the temperature of the microneedle, etc., and achieve the effects of convenient operation, avoiding first-pass effect and high compliance.

Active Publication Date: 2022-04-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although microneedle administration has many advantages, it is difficult to control the speed of drug release, and it is also impossible to control the temperature at which the microneedle penetrates into the lesion.

Method used

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  • Microneedle drug release device and manufacturing method, skin disease treatment device
  • Microneedle drug release device and manufacturing method, skin disease treatment device
  • Microneedle drug release device and manufacturing method, skin disease treatment device

Examples

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Effect test

Embodiment

[0053] In this example, the therapeutic drug is 5-fluorouracil, and the photothermal conversion agent is indocyanine green. Applied basic research of drug device in the treatment of epidermal cancer.

[0054] Materials: microneedle template, sodium hyaluronate, polyethylene glycol, stannous octoate, caprolactone, 5-fluorouracil, indocyanine green, trypan blue, etc.

[0055] Cells: human skin squamous cell line A431, cultured in DMEM medium with 10% fetal bovine serum, 100 U / mL penicillin, and 100 U / mL streptomycin.

[0056] Animals: SPF grade female BALB / CA-nu mice, 6-8 weeks old, were purchased from Beijing Huafukang Biotechnology Co., Ltd. All animal experiments were carried out under the approval and supervision of the Animal Management Committee of the State Key Laboratory of Biotherapy, Sichuan University.

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Abstract

The invention discloses a manufacturing method related to the field of biomedicine, especially a microneedle drug release device, comprising the following steps: A, making a drug release device from a therapeutic drug and a drug-loaded substance by a double emulsification method; making a microneedle system carrier material; B. 1. Add the drug release device into the microneedle template, and then fill the microneedle template with the carrier material of the microneedle system; C. Take it out after drying to obtain the microneedle drug release device. By adding a photothermal conversion agent to the drug-loaded particles, the drug-release device can absorb light of a specific wavelength, and the drug-loaded particles containing therapeutic drugs are delivered to the diseased tissue, and the drug-loaded particles are released. When irradiated with light, the drug-loaded particles The photothermal conversion agent in the drug particles converts light energy into heat energy, which can not only make the diseased tissue hyperthermic to kill the lesion, but also control the release behavior of the therapeutic drug in the drug-loaded particles, so as to achieve the goal of synergistic treatment between chemotherapy and photothermal therapy.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a microneedle medicine release device, a manufacturing method, and a skin disease treatment device. Background technique [0002] Epidermal diseases include microbial infection, cancer, and injury. Taking epidermal cancer as an example, epidermal cancer is a malignant skin tumor. With the aging of the population in my country, its incidence rate is gradually increasing. According to the source of tumor cells, epidermal malignancies can be divided into squamous cell carcinoma, basal cell carcinoma, and malignant melanoma. Epidermal malignancies are superficial and are usually treated with surgical excision, radiation therapy, chemotherapy, and laser therapy. Surgical therapy may not be able to completely remove the remaining tumor cells, which can easily lead to tumor recurrence. Radiotherapy and chemotherapy will have a certain therapeutic effect, but they will produce serious side e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61N5/06A61K9/50A61K47/34A61K31/513A61K41/00A61P35/00
CPCA61M37/0015A61N5/0616A61N5/062A61N5/0625A61K9/0021A61K9/5031A61K31/513A61K41/0042A61K41/0052A61P35/00A61M2037/0023A61M2037/0046A61M2037/0053A61M2037/0061A61N2005/0659A61N2005/0664
Inventor 钱志勇郝颖
Owner SICHUAN UNIV
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