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Curcumin microencapsulation method

A technology of curcumin and microencapsulation, which is applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of short storage period and poor stability of curcumin, and achieve the effects of improved encapsulation, water solubility, and anti-oxidation Effect

Inactive Publication Date: 2020-08-04
右江民族医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the problems that current curcumin has poor stability and short storage period

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A method for curcumin microencapsulation, comprising the steps of:

[0024] (1) Dissolve curcumin in a solvent composed of 10 times the weight of ethyl acetate and ethanol (volume ratio 1:3), and then add curcumin with 3.5% tea saponin, 6% lactic acid fatty acid glyceride and Triglycerol monostearate 2%, heat up to 70°C, stir evenly to obtain core material solution;

[0025] (2) Use phlorizin, mogroside V, rhamnolipid and xanthan gum at a mass ratio of 2:3:5:25 as the wall material, add water 15 times the weight of the wall material, stir evenly, and heat up to 70 ℃, to obtain the capsule material solution;

[0026] (3) Add the core material solution to the capsule material solution while it is hot, add it to the homogenizer at a mass ratio of 1:3, and homogenize for 3 times at a pressure of 50 MPa, each time for 20 minutes, to obtain a mixed solution;

[0027] (4) Send the mixed solution to a granulation sprayer for spray drying to a moisture content of 4.8%. The spr...

Embodiment 2

[0032] A method for curcumin microencapsulation, comprising the steps of:

[0033] (1) Dissolve curcumin in a solvent composed of 9 times the weight of ethyl acetate and ethanol (volume ratio 1:4), and then add curcumin with 4% tea saponin, 5% lactic acid fatty acid glyceride and Triglycerol monostearate 1.5%, warming up to 65°C, stirring evenly to obtain a core material solution;

[0034] (2) Use phlorizin, mogroside V, rhamnolipid and xanthan gum at a mass ratio of 1:1:3:20 as the wall material, add water 10 times the weight of the wall material, stir evenly, and heat up to 65 ℃, to obtain the capsule material solution;

[0035] (3) Add the core material solution to the capsule material solution while it is hot, add it to the homogenizer at a mass ratio of 1:2, and homogenize twice under a pressure of 60 MPa, each time for 30 minutes, to obtain a mixed solution;

[0036] (4) Send the mixed solution to a granulation sprayer for spray drying to a moisture content of 4.6%. Th...

Embodiment 3

[0038] A method for curcumin microencapsulation, comprising the steps of:

[0039] (1) Dissolve curcumin in a solvent composed of 10 times the weight of ethyl acetate and ethanol (volume ratio 1:3), and then add curcumin with 3.5% tea saponin, 7% lactic acid fatty acid glyceride and Triglycerol monostearate 2.5%, warming up to 60°C, stirring evenly to obtain a core material solution;

[0040] (2) Use phlorizin, mogroside V, rhamnolipid and xanthan gum as the wall material with a mass ratio of 3:2:5:30, add water 12 times the weight of the wall material, stir evenly, and heat up to 60 ℃, to obtain the capsule material solution;

[0041] (3) Add the core material solution to the capsule material solution while it is hot, add it to the homogenizer at a mass ratio of 1:4, and homogenize for 3 times under a pressure of 50 MPa, each time for 15 minutes, to obtain a mixed solution;

[0042] (4) Send the mixed solution to a granulation sprayer for spray drying to a moisture content ...

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PUM

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Abstract

The invention discloses a curcumin microencapsulation method which comprises the following steps: dissolving curcumin in a solvent consisting of ethyl acetate and ethanol with the weight being 8-10 times that of curcumin, then adding tea saponin, lactic acid fatty glyceride and tripolyglycerol monostearate, heating, and uniformly stirring to obtain a core material solution; the preparation methodcomprises the following steps: taking phlorizin, mogroside V, rhamnolipid and xanthan gum as wall materials, adding water of which the weight is 10-15 times that of the wall materials, uniformly stirring, and heating to 60-70 DEG C to obtain a capsule material solution; adding the core material solution into the capsule material solution according to a mass ratio of 1: (2-4), and adding into a homogenizer for homogenizing treatment to obtain a mixed solution; and sending the mixed solution into a granulation sprayer for spray drying, and cooling to room temperature to obtain the curcumin microcapsules. According to the method disclosed by the invention, the curcumin is microencapsulated, so that efficient encapsulation of the curcumin can be effectively realized, the stability of the curcumin is improved, the storage period is prolonged, and the water solubility of the curcumin is improved; the medicine effects of oxidation resistance, blood sugar reduction, inflammation resistance andthe like of the curcumin microcapsules can also be enhanced, and the bad taste of curcumin is hidden.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a method for microencapsulating curcumin. Background technique [0002] Curcumin is a natural active ingredient extracted from the dried rhizomes of turmeric, turmeric, and zedoary. Curcumin is an orange-yellow crystalline powder with a slightly bitter taste and is insoluble in water. It is mainly used in food production for coloring sausage products, canned food, and stewed sauce products. Medical research shows that curcumin has the effects of lowering blood fat, anti-tumor, anti-inflammatory, choleretic, and anti-oxidation. [0003] At present, curcumin is only extracted from plants and dried to obtain dry powder for storage. However, curcumin dry powder is not protected by other media, and it is prone to oxidative degradation under the action of light, high temperature and oxygen, resulting in a decrease in drug efficacy. Microcapsule technology uses na...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/12A61K31/704A61K47/28A61K47/14A61K47/26A61K47/36A61P39/06A61P3/10A61P29/00
CPCA61K9/5036A61K9/5015A61K31/12A61K31/704A61K47/28A61K47/14A61P39/06A61P3/10A61P29/00A61K2300/00
Inventor 黄锁义陈石梅雷智冬林瑶周世友卢丽香
Owner 右江民族医学院
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