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Preparation method of two-component medical adhesive

An adhesive, two-component technology, used in pharmaceutical formulations, surgical adhesives, applications, etc., can solve problems such as degradation product toxicity, shorten curing time, and long curing time, achieve reduced pain, low swelling, enhanced The effect of comfort

Active Publication Date: 2020-07-28
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, urethane-based adhesives mainly face three problems: 1. Long curing time
2. Toxicity and carcinogenicity of degradation products
Shorter cure times when using more reactive aromatic isocyanates such as toluene diisocyanate or methylene diphenyl diisocyanate, but are more toxic and may release carcinogenic aromatic diamines

Method used

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  • Preparation method of two-component medical adhesive
  • Preparation method of two-component medical adhesive
  • Preparation method of two-component medical adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1, trimethylolpropane tris(3-mercaptopropionate) (39.86g, 10mmol) was dissolved in 240mL N'N-dimethylformamide, N 2 Bubble 30min to remove the air in the solution, then add 3-(acryloyloxy)-methacrylic acid-2-hydroxypropyl ester (19.28g, 9mmol), N 2 Under the protection of 40 ° C reaction for 24h. After the reaction, the reaction solution was concentrated by a rotary evaporator, and then precipitated in anhydrous ether to obtain a colorless transparent viscous liquid. The product was then redissolved in 40 mL of dichloromethane and precipitated by adding to 400 mL of diethyl ether. Repeat the above dissolution-precipitation operation 3 times, and vacuum dry to obtain a colorless viscous hyperbranched polymer component A, which is recorded as HBP1 and has a molecular weight of 8 kDa.

[0029] Step 2: Weigh 40g of polyethylene glycol and dissolve it in 150mL of toluene, raise the temperature to 140°C and reflux for 3 hours through the water separator to remove the m...

Embodiment 2

[0032] Same as Example 1, but change the addition amount of isocyanate-functionalized polyethylene glycol (PEG-NCO, 1 mol in terms of isocyanate functional group) in step 3), and the rest of the operations are the same to obtain an adhesive, which is named 1-1.

Embodiment 3

[0034] Same as Example 1, but change the addition amount of isocyanate-functionalized polyethylene glycol (PEG-NCO, 1.5 mol in terms of isocyanate functional group) in step 3), and the rest of the operations are the same to obtain the adhesive, named 1-1.5 .

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Abstract

The invention provides a preparation method of a two-component medical adhesive, and belongs to the field of biomedical materials. The two-component instant adhesive is prepared by mixing a hyperbranched polymer which is in a liquid state at room temperature and has a thiol group as a terminal group and polyethylene glycol terminated by hexamethylene diisocyanate. The curing time of the adhesive is relatively short (1.5-3 min), so that the adhesive has a certain operation window, and the adhesive and the polyethylene glycol can be mixed and can be quickly cured when the adhesive is applied totissues. The medical adhesive can have a shear modulus close to that of various biological soft tissues by controlling the proportion of the two components, so that the interfacial stress concentration is relieved and the comfort of a patient is enhanced. The adhesive has very high tissue adhesiveness due to a large number of isocyanate groups and a solvent-free hyperbranched polymer network structure, and the adhesive property of the adhesive can be comparable with that of cyanoacrylate glue. The medical adhesive also has low swelling property and low toxicity, and has a great practical medical value.

Description

technical field [0001] The application belongs to the field of biomedical materials, and in particular relates to a preparation method of a solvent-free medical adhesive. Background technique [0002] Biomedical adhesive, as the name implies, is a medical adhesive material applied to the human body. It can be simply applied to the wound site, and through bonding, the tissue and tissue or non-tissue can be bonded together, so as to achieve wound closure, hemostasis and sealing. The medical adhesive is easy and quick to operate, does not cause damage to the damaged area, reduces pain, does not require secondary surgery to remove sutures, and can effectively prevent body fluids and air from leaking. Medical adhesives are widely used and have various functions. They can not only be used to close skin wounds, but also can be used to repair bones, nerves, muscles and other tissues. In addition, medical adhesives can also have superior cosmetic effects, leaving no scars after wou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00
CPCA61L24/001A61L24/046A61L2400/04C08L75/04C08L81/02
Inventor 李小杰张一帆魏玮刘晓亚
Owner JIANGNAN UNIV
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