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A millimeter-scale multi-core capsule for delivering nutrients/drugs to the small intestine and slow-release and its preparation method and application

A technology of multi-core capsules and nutrients, which is applied in the fields of targeted carriers, food and medicine, can solve the problems of single bioavailability, rapid release behavior, uneven distribution, etc., and achieve a suitable loading rate and a simple and easy preparation method Effect

Active Publication Date: 2022-07-05
SHANGHAI OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its non-ideal behavior such as uneven distribution, single bioavailability and rapid release behavior, and the size is micron level, further research is still needed

Method used

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  • A millimeter-scale multi-core capsule for delivering nutrients/drugs to the small intestine and slow-release and its preparation method and application
  • A millimeter-scale multi-core capsule for delivering nutrients/drugs to the small intestine and slow-release and its preparation method and application
  • A millimeter-scale multi-core capsule for delivering nutrients/drugs to the small intestine and slow-release and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The preparation of embodiment 1 sodium alginate solution

[0062] Weigh a certain amount of sodium alginate solid powder and disperse it in ultrapure water, swell in a 40°C water bath for 30 minutes, and use a magnetic stirrer to stir at a rate of 500rpm for 3-4h (mainly based on dissolution) to ensure complete dissolution. , stand for defoaming to obtain sodium alginate solutions with concentrations of 0.25wt%, 0.5wt%, 1.0wt%, 2.0wt%, 3.0% and 4.0wt%.

Embodiment 2

[0063] The preparation of embodiment 2 sodium alginate emulsion

[0064] Measure 6mL of the above-mentioned sodium alginate solution, add 2mL of fish oil according to the ratio of sodium alginate solution: fish oil=3:1 (volume ratio), use a 10mm head homogenizer to homogenize for 60s at a speed of 8000rpm to obtain a sodium alginate emulsion; like figure 2 As shown in the digital camera image at 0 h, the sodium alginate emulsion was milky white. like figure 1 These emulsions consisted of fish oil droplets as shown in the inverted optical microscope image (OM image), which is consistent with the characterised structure of conventional emulsions, proving that they are emulsions. The droplet diameters were most varied at low alginate concentrations (0.25% and 0.5%), and the droplets at the 2.0% alginate concentration were more uniform in diameter. Use a digital camera to observe how these emulsions are stored at room temperature for 24 hours ( figure 2 ). The initial emuls...

Embodiment 3

[0065] The preparation of embodiment 3 sodium alginate millimeter-level multi-core capsules

[0066] Millimeter-sized multinuclear capsules were prepared using an electrostatic sprayer (Changshan Naiyi Co., Ltd., model JDE01). with 25mM CaCl 2The solution is used as the receiving liquid, the operating temperature is 25-30°C, and the relative humidity is 30%-40%. The sodium alginate emulsion (2.0%) was put into a 5 mL syringe, and the syringe was connected to a pipeline, and the inner diameter of the needle at the other end of the pipeline was 0.60 mm. A high-voltage power supply was used, and the applied voltage was 10kV. Set the feed rate to 30 μL / min. The distance between the needle and the liquid level of the receiving liquid is 10 cm. Connect the needle tube, pipeline and needle to the electrostatic sprayer, turn on the equipment and spray the sodium alginate emulsion into the calcium chloride receiving solution, and gelation reaction occurs to prepare millimeter-level...

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Abstract

The present invention provides a millimeter-scale multi-core capsule for delivering nutrients / drugs to the small intestine for sustained release, and a preparation method and application thereof. The millimeter-scale multi-core capsule includes a wall material and an oily substance, and the oily substance is uniformly or non-uniformly distributed inside the wall material in the form of uniform or non-uniform oily droplets to form a millimeter-scale multi-core capsule. There are bumps on the surface, the inside of the bumps contains oily droplets, and the wall material is calcium ion cross-linked alginate or calcium ion cross-linked alginate and surfactant. The whole preparation method of the invention is simple and easy to implement, does not involve complex polymer modification and formulation, the prepared millimeter-scale multi-core capsules are mainly released in simulated small intestinal fluid, and have not been released in simulated gastric fluid, and are especially suitable for oral administration The purpose of the medicine is to specifically transport fish oil to the small intestine and release oily substances / drugs slowly in the small intestine, and it can be used as a specific carrier to deliver nutrients and drugs.

Description

technical field [0001] The invention relates to the fields of food, medicine and the like, in particular to a millimeter-scale multi-core capsule for delivering nutrients / drugs to the small intestine and slow-release, a preparation method and application thereof, and is suitable for the field of targeting carriers. Background technique [0002] The research and development of multi-scale millimeter-scale multi-core encapsulation technology has become a hot spot in the food and pharmaceutical industries due to its great advantages for active substances. Factors such as oxygen and heat, ③ controlled retention and release in vitro and in vivo, ④ conversion of liquid form to solid form for easy handling and storage. The preparation of centimeter-scale and millimeter-scale multi-core capsules and micro / nano millimeter-scale multi-core capsules is currently the mainstream encapsulation technology in academia and industry. For some people, such as children, the elderly and some pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K9/52A61K47/36A61K47/26A61K35/60A61P29/00A61P3/06A61P9/00A23L33/115A23L33/125A23P10/30
CPCA61K9/5036A61K9/5031A61K35/60A61P29/00A61P3/06A61P9/00A23L33/115A23L33/125A23P10/30A23V2002/00A23V2200/30
Inventor 钟建陶丽娜王盼盼张婷王锡昌
Owner SHANGHAI OCEAN UNIV
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