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Millimeter-level polykaryon capsules for transporting nutrient substances/medicines to small intestines and realizing slow release and preparation method and application of millimeter-level polykaryon capsules

A nutrient substance and multi-core capsule technology, which is applied in the field of targeting carrier, food and medicine, can solve the problems of uneven distribution, single bioavailability and rapid release behavior, and achieve the simple and convenient preparation method and appropriate loading rate Effect

Active Publication Date: 2020-07-28
SHANGHAI OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its non-ideal behavior such as uneven distribution, single bioavailability and rapid release behavior, and the size is micron level, further research is still needed

Method used

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  • Millimeter-level polykaryon capsules for transporting nutrient substances/medicines to small intestines and realizing slow release and preparation method and application of millimeter-level polykaryon capsules
  • Millimeter-level polykaryon capsules for transporting nutrient substances/medicines to small intestines and realizing slow release and preparation method and application of millimeter-level polykaryon capsules
  • Millimeter-level polykaryon capsules for transporting nutrient substances/medicines to small intestines and realizing slow release and preparation method and application of millimeter-level polykaryon capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The preparation of embodiment 1 sodium alginate solution

[0062] Weigh a certain amount of sodium alginate solid powder and disperse it in ultrapure water, swell in a 40°C water bath for 30 minutes, and use a magnetic stirrer to stir at a rate of 500rpm for 3-4h (based on the dissolution situation) to ensure that it is completely dissolved , let it stand still to defoam, and obtain sodium alginate solutions with concentrations of 0.25wt%, 0.5wt%, 1.0wt%, 2.0wt%, 3.0% and 4.0wt%.

Embodiment 2

[0063] The preparation of embodiment 2 sodium alginate emulsion

[0064] Measure 6 mL of the above-mentioned sodium alginate solution, add 2 mL of fish oil according to the ratio of sodium alginate solution: fish oil = 3:1 (volume ratio), and use a homogenizer with a 10 mm head at a speed of 8000 rpm for 60 seconds to obtain a sodium alginate emulsion; Such as figure 2 As shown in the digital camera image in 0h, the sodium alginate emulsion is milky white. Such as figure 1 Inverted optical microscope images (OM images) showed that these emulsions consisted of fish oil droplets, which was consistent with the characterized structure of traditional emulsions, proving that they were emulsions. Droplet diameters were most varied at low alginate concentrations (0.25% and 0.5%), and more uniform at 2.0% alginate concentrations. Use a digital camera to observe the situation of these emulsions stored at room temperature for 24 hours ( figure 2 ). The initial milking times of th...

Embodiment 3

[0065] The preparation of embodiment 3 sodium alginate millimeter grade multi-core capsules

[0066] Millimeter-sized multinuclear capsules were prepared using an electrostatic sprayer (Changsha Nayi Co., Ltd., model JDE01). With 25mM CaCl 2The solution is used as a receiving liquid, the operating temperature is 25-30° C., and the relative humidity is 30%-40%. Sodium alginate emulsion (2.0%) was filled into a 5 mL syringe, the syringe was connected to the pipeline, and the inner diameter of the needle at the other end of the pipeline was 0.60 mm. A high-voltage power supply is used, and the applied voltage is 10kV. Set the feed rate to 30 µL / min. The distance between the needle and the liquid surface of the receiving liquid is 10 cm. Connect the needle tube, pipe and needle to the electrostatic sprayer, turn on the device and spray the sodium alginate emulsion into the calcium chloride receiving solution, a gelation reaction occurs, and a millimeter-scale multi-core capsul...

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Abstract

The invention provides millimeter-level polykaryon capsules for transporting nutrient substances / medicines to small intestines and realizing slow release and a preparation method and application of the millimeter-level polykaryon capsules. The millimeter-level polykaryon capsules comprise a wall material and oil substances, wherein the oil substances are evenly or unevenly distributed on the innerwall of the wall material in the manner of uniform or ununiform oil droplets, so that the millimeter-level polykaryon capsules are obtained. Bulges are formed on the surfaces of the millimeter-levelpolykaryon capsules, and the oil droplets are placed in the ridges. The wall material is calcium ion cross-linking alginate or calcium cross-linking alginate and a surfactant. The entire preparation method is simple and easy to operate, complex polymer modification and formulas are not added, and the prepared millimeter-level polykaryon capsules are mainly released during simulation of small intestinal juice and are not released in simulation of gastric juice. The millimeter-level polykaryon capsules are particularly suitable for medication through mouths to specially transport fish oil to thesmall intestines and realize slow release of the fish oil / medicines in the small intestines, and can be used for transporting nutrient substances and medicines as specific carriers.

Description

technical field [0001] The invention relates to the fields of food and medicine, in particular to a millimeter-scale multi-core capsule for delivering nutrients / drugs to the small intestine for sustained release, its preparation method and application, and is suitable for the field of targeting carriers. Background technique [0002] The research and development of multi-scale millimeter-scale multi-core encapsulation technology has become a hotspot in the food and pharmaceutical industries because of its great advantages over active substances. Factors such as oxygen and heat, ③ controllable in vitro and in vivo retention and release, ④ conversion of liquid form to solid form for easy handling and storage. The preparation of centimeter-scale and millimeter-scale multi-core capsules and micro / nano-millimeter-scale multi-core capsules is currently the mainstream encapsulation technology in academia and industry. For some people, such as children, the elderly and some patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K9/52A61K47/36A61K47/26A61K35/60A61P29/00A61P3/06A61P9/00A23L33/115A23L33/125A23P10/30
CPCA61K9/5036A61K9/5031A61K35/60A61P29/00A61P3/06A61P9/00A23L33/115A23L33/125A23P10/30A23V2002/00A23V2200/30
Inventor 钟建陶丽娜王盼盼张婷王锡昌
Owner SHANGHAI OCEAN UNIV
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