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Preparation method and application of platycodin D

A technology of platycodon saponin and microbial strains, applied in the direction of microbial-based methods, biochemical equipment and methods, and medical preparations containing active ingredients, which can solve the problems of limited conversion pathways for a single strain and inability to fully utilize saponin resources, etc. To achieve the effect of increasing productivity

Active Publication Date: 2020-07-10
YANBIAN UNIV
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Problems solved by technology

[0006] At present, domestic and foreign studies on the biotransformation of saponins have found that the transformation pathway of a single strain is limited, and saponin resources cannot be fully utilized. Therefore, many scholars have begun to use mixed enzyme systems and mixed strains for biotransformation research, and the effect is ideal. Transformation from traditional single strain

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  • Preparation method and application of platycodin D
  • Preparation method and application of platycodin D
  • Preparation method and application of platycodin D

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Embodiment Construction

[0029] In order for those skilled in the art to more clearly understand the purpose, technical solutions and advantages of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0030] A strain of Pichia kudriazwii of the present invention is preserved in the General Microbiology Center of the China Microorganism Culture Collection Administration Committee, the preservation date is June 17, 2019, and the preservation number is CGMCC No. 17939.

[0031] The present invention is a method for preparing Platycodon saponin D by using the above-mentioned Pichia azweiweis strain, comprising the following steps: a culturing step: YPD liquid medium and yeast extract peptone are selected for the cultivation of the Pichia azweii. Dextrose...

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Abstract

The invention belongs to a preparation method for platycodin D, and adopts a mixed bacterial strain which includes a Pichia kudriavzevii bacterial strain and a Bacillus velezensis bacterial strain toprepare the platycodin D. According to the preparation method, two types of bacterial strains with different conversion mechanisms are used for the first time to convert platycodin in a mixed fermentation way, and the yield of the platycodin D and deapioplatycodin D can be effectively improved. By use of bacterial strain fermentation characteristics, the platycodin can be subjected to biological transformation, the safe and environmentally-friendly production of the platycodin can be realized, platycodon grandiflorum resources can be fully utilized, and the platycodin which is contained in theplatycodon grandiflorum resources and has low biological activity can be converted into saponin with high biological activity so as to achieve an effect of recycling waste materials.

Description

technical field [0001] The invention relates to a preparation method and application of platycodon saponin, and relates to a preparation method and application of platycodon saponin prepared by adopting a mixed strain including Pichia kudriazwii strain and Bacillus velesii. Background technique [0002] Platycosides have the functions of treating hyperlipidemia, hypertension, diabetes, obesity, etc., and the main biologically active components are triterpene saponins (platycosides). According to the survey, more than 30 kinds of Platycodin saponins and various saponins have been isolated and identified. Platycodin D (Platycodin D), referred to as PD, is a white crystalline powder with a density of 1.56g / cm 3 , with a melting point of 228-237°C and a molecular formula of C 57 h 92 o 28 , relative molecular weight is 1224.58, good water solubility. Platycodon saponin D is a kind of platycodon acid disaccharide chain saponin, and its sugar groups are respectively connected ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/16C12N1/20C12P39/00C12P33/20A61K31/7048A61P35/00A61P29/00A61P37/02A61P3/04A61P1/16A61P3/10A61P13/12C12R1/84C12R1/07
CPCC12P39/00C12P33/20A61K31/7048A61P35/00A61P29/00A61P37/02A61P3/04A61P1/16A61P3/10A61P13/12C12R2001/07C12N1/205C12R2001/84C12N1/165
Inventor 金清黄存辉朴泓洁李官浩崔福顺崔虎山
Owner YANBIAN UNIV
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