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Traditional Chinese medicine gel agent for treating cutaneous pruritus

A technology of skin itching and gel, which is applied in the field of traditional Chinese medicine preparations, can solve problems such as low content of active ingredients in medicines, prone to lactation, delamination, and interception of medicine ingredients

Active Publication Date: 2020-07-07
MAYINGLONG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this Chinese medicine still has following defective: 1) emulsifiable paste contains more oil, can produce residue after skin is used, and under harsh environment, decrepitation, delamination are prone to occur, and medicine shelf-life is short, and lotion is inconvenient to use and is not easy to control dose ; 2) The active ingredient content of the drug is low, and the curative effect needs to be further improved; 3) Ultrafiltration will cause most of the drug ingredients to be intercepted, the product yield is very low, and the production cost is very high

Method used

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  • Traditional Chinese medicine gel agent for treating cutaneous pruritus
  • Traditional Chinese medicine gel agent for treating cutaneous pruritus
  • Traditional Chinese medicine gel agent for treating cutaneous pruritus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Cnidium 12g, Sophora flavescens 12g, Phellodendron 12g, Fangfeng 12g, Digupi 8g, Kochia chinensis 8g, Clematis 8g, Baixianpi 8g, Baibu 8g, Atractylodes 8g, purslane 8g, mugwort leaves 5g, mint 5g

[0027] Preparation method: 1) Weigh six times of the prescription amount of Chinese medicinal materials, first percolate with 5 times the weight of 85% ethanol, and recover the ethanol from the percolation liquid until there is no alcohol smell, and set aside;

[0028] 2) decocting the dregs after percolation in step 1) with water twice, each time for 2 hours, collecting the decoction, then merging with the percolation liquid in step 1), and concentrating to a clear paste with a relative density of 1.15;

[0029] 3) Divide the clear paste into six parts on average, five of which are applied to five macroporous adsorption resin columns of type D101, DA201, AB-8, ADS-7 and HPD-100, and the loading amount is 0.5g of clear paste. Cream / ml column volume, first eluted with water f...

Embodiment 2

[0039] Cnidium 12g, Sophora flavescens 12g, Phellodendron 12g, Fangfeng 12g, Digupi 8g, Kochia chinensis 8g, Clematis 8g, Baixianpi 8g, Baibu 8g, Atractylodes 8g, purslane 8g, mugwort leaves 5g, mint 5g

[0040] Preparation method 1: 1) Weigh the prescribed amount of Chinese medicinal materials, first use 3 times the weight of 95% ethanol to percolate, and recover the ethanol from the percolation liquid until it has no alcohol smell, and set it aside;

[0041] 2) decocting the dregs after percolation in step 1) with water for 3 times, each time for 1 hour, collecting the decoction, then merging with the percolation liquid in step 1), and concentrating to a clear paste with a relative density of 1.15;

[0042] 3) Put the clear cream on the DA201 macroporous adsorption resin column, the loading volume is 0.5g clear cream / ml column volume, first elute with water for 3 times the column volume, then use 50% ethanol for 6 times the column volume, collect the ethanol The eluate was ...

Embodiment 3

[0055] The preparation of gel, prescription is as follows:

[0056] Table 3 gel formula table

[0057]

[0058]

[0059] Preparation method: 1) adding carbomer and hydroxypropyl methylcellulose to 20% ethanol to form a gel solution;

[0060] 2) The Chinese medicine active ingredient and chlorhexidine acetate obtained after purification by DA201 macroporous resin in Example 1 were added to the gel solution, stirred and mixed;

[0061] 3) Add propylene glycol and menthol, stir and mix;

[0062] 4) Finally, triethanolamine is added, filled after homogenization, and sterilized.

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Abstract

The present invention discloses a traditional Chinese medicine gel agent for treating cutaneous pruritus. The traditional Chinese medicine gel agent consists of a traditional Chinese medicine active ingredient, an antibacterial active ingredient and a gel matrix, wherein the traditional Chinese medicine active ingredient is prepared by extraction and purification of 13 Chinese herbal medicines intotal which include fructus cnidii, radix sophorae flavescentis, cortex phellodendri, radix saposhnikoviae, cortex lycii radicis, fructus kochiae, radix clematidis, cortex dictamni, radix stemonae, rhizoma atractylodis, herba portulacae, folium artemisiae argyi and mint. By improving an existing traditional Chinese medicine extraction method, the active ingredient content and the curative effect of the medicines are improved, the prepared gel agent has the relatively high transdermal absorption performance, and compared with an existing dosage form, the traditional Chinese medicine gel agent has the advantages of convenient use, no residue, longer quality guarantee period and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine gel for treating skin pruritus. Background technique [0002] CN 104288634A discloses a traditional Chinese medicine for treating anal itching, which is made of thirteen traditional Chinese medicinal materials such as cnidium fruit, flavescens, cortex cortex, windproof and digupi. The traditional Chinese medicine has the effects of clearing away heat and dampness, killing insects and relieving itching, and can be used to treat skin itching. The invention extracts and purifies traditional Chinese medicines and makes them into lotions, creams or gels. The prepared medicines have good anti-inflammatory, antibacterial, antipruritic and anti-allergic effects, and at the same time, in order to promote the transdermal To absorb and improve curative effect, the invention also extracts volatile oil from Chinese herbal med...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/06A61P17/04A61K31/155A61K31/14A61K31/085A61K31/055A61K31/785
CPCA61K9/06A61K31/055A61K31/085A61K31/14A61K31/155A61K31/785A61K36/185A61K36/234A61K36/238A61K36/282A61K36/284A61K36/489A61K36/534A61K36/716A61K36/75A61K36/756A61K36/815A61K36/904A61K47/38A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P17/04A61K2300/00
Inventor 陈平朱学明刘尉杨向东张文慧
Owner MAYINGLONG PHARMA GROUP
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