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Polymer drug-loaded film for artificial cochlear implant, artificial cochlear drug-loaded electrode and preparation method

A technology of cochlear implant and polymer carrier, applied in the field of medical devices, can solve problems such as damage to auditory reconstruction, residual hearing, etc., and achieve the effects of facilitating hearing protection, inhibiting the formation of local fibrous tissue, and simple process

Inactive Publication Date: 2020-06-26
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the technical problem that the pathological changes of the inner ear after cochlear implantation are likely to damage the effect of auditory reconstruction and the residual hearing before operation. The purpose of medication can effectively improve the hearing loss caused by postoperative lesions

Method used

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  • Polymer drug-loaded film for artificial cochlear implant, artificial cochlear drug-loaded electrode and preparation method
  • Polymer drug-loaded film for artificial cochlear implant, artificial cochlear drug-loaded electrode and preparation method
  • Polymer drug-loaded film for artificial cochlear implant, artificial cochlear drug-loaded electrode and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Taking the most commonly used dexamethasone sodium phosphate (DSP) as an example, the doctor decided that the electrode drug loading plan for this operation is to add 10% DSP to the PLGA chloroform solution with a mass fraction of 5%. That is, under this condition, the surface of each electrode implant segment will be covered with about 800 μg of PLGA film, which contains 80 μg of DSP, and they will be implanted into the inner ear together.

[0039] At room temperature, prepare the corresponding amount of drug and PLGA chloroform solution in a brown light-proof wide-mouth glass container with a cover (such as a Petri dish) according to the requirements of this drug loading protocol, and stir evenly to obtain a precursor solution for later use.

[0040] By holding the cochlear implant clamping device, the operator assists to completely immerse the electrode implanted segment of the cochlea in the above-mentioned prepared precursor solution. After 1-3 seconds, the fully co...

Embodiment 2

[0044] In the PLGA chloroform solution with a mass fraction of 6%, add DSP accounting for 15% of the PLGA mass ratio, that is, under this condition, the surface of each electrode implanted segment will cover about 1000 μg of PLGA film, which contains the mass of DSP 150μg, implanted together in the inner ear.

[0045] At room temperature, prepare the corresponding amount of drug and PLGA chloroform solution in a brown light-proof wide-mouth glass container with a cover (such as a Petri dish) according to the requirements of this drug loading protocol, and stir evenly to obtain a precursor solution for later use.

[0046] By holding the cochlear implant clamping device, the operator assists to completely immerse the electrode implanted segment of the cochlea in the above-mentioned prepared precursor solution. After 1-3 seconds, the fully covered precursor solution is slowly taken out perpendicular to the liquid surface After the precursor solution is naturally leveled and dried...

Embodiment 3

[0050] The method is the same as in Example 1, except that the formulation of the precursor solution is different.

[0051] The formulation of the precursor solution in this embodiment is: in the chloroform solution of PLGA with a mass fraction of 4%, cytarabine hydrochloride with a mass ratio of 1% of PLGA is added.

[0052] The prepared polymer drug-loaded coating film is smooth, uniform and thin, and its surface contact angle is about 76.60°, which is significantly smaller than that before coating.

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Abstract

The invention discloses a polymer drug-loaded film for artificial cochlear implant, an artificial cochlear drug-loaded electrode and a preparation method. The polymer drug-loaded film includes a biodegradable polymer carrier, the loaded drug, and a volatile solvent. The loaded drug refers to the drug used to prevent and treat inner ear lesions after cochlear implantation. The polymer carrier is soluble in the volatile solvent, and the mass concentration is 4%-6%. The mass ratio of the loaded drug to the polymer carrier is adjusted as needed. The artificial cochlear implant drug-loaded electrode includes an electrode implantation section, the electrode implantation section has several metal contact points, and the surface of the electrode implantation section is covered with the polymer drug-loaded film, except for the metal contact points. The artificial cochlear implant drug-loaded electrode provided by the invention can be quickly customized during surgery. The surface of the artificial cochlear implant electrode accepts a carrier to jointly load the drug. The loaded drug is slowly released after surgery to achieve the purpose of combined medication, so that can effectively improve postoperative inner ear inflammation and residual hearing loss caused by fibrosis and other diseases.

Description

technical field [0001] The invention belongs to the field of medical devices and relates to cochlear implant technology, in particular to a polymer drug-loaded film for cochlear implants, a cochlear drug-loaded electrode and a preparation method. Background technique [0002] Cochlear implantation is currently almost the only treatment for severe and extremely severe deafness. It can rebuild the hearing of patients, improve the quality of life, and enable patients to reintegrate into society. However, the pathological changes of the inner ear after cochlear implantation (such as inflammatory stimulation, fibrous proliferation, neuron apoptosis, etc.) are likely to damage the effect of auditory reconstruction and preoperative residual hearing. [0003] Current clinical research has confirmed that relying solely on advances in surgical techniques and improvements in electrode design is not enough to solve the above problems. Combining drugs to prevent inner ear lesions after c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16A61M31/00A61N1/05
CPCA61L31/148A61L31/16A61L31/10A61N1/0541A61M31/00A61L2400/18A61L2300/43A61L2300/232A61L2300/41
Inventor 于浩然贾欢
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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