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Magnetic nano composite material and preparation method and application of material

A technology of magnetic nano-composite materials, applied in the field of medical materials, can solve the problems of reduced MRIT1 contrast enhancement efficiency and reduced yield, etc.

Active Publication Date: 2020-06-26
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the co-precipitation method used in the preparation process of the material, there are certain problems in the crystallinity, coating, bonding mode and other aspects of the material, which lead to a decrease in the MRI T1 contrast enhancement efficiency, r1 value <10, and the output will be corresponding. to lower

Method used

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  • Magnetic nano composite material and preparation method and application of material
  • Magnetic nano composite material and preparation method and application of material
  • Magnetic nano composite material and preparation method and application of material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0175] Example 1 Sample 1 # preparation of

[0176] 1. Add 4.325g FeCl 3 .6H 2 O and 2.386 g FeCl 2 .4H 2 O was mixed and dissolved in 300mL water; concentrated nitric acid solution (9ml, 16M) was added dropwise, marked as mixed solution A;

[0177] 2. Quickly add 60 mg of carboxyl-PEG-amino powder to the mixed solution A, mix quickly, and mark it as mixed solution B;

[0178] 3. Rapidly raise the temperature of the mixed solution B to 65°C, and pass it into Ar for protection, add ammonia solution (500ml, volume percentage=20%) dropwise, adjust the pH value to 11, and the solution turns black rapidly;

[0179] 4. Continue to react for 1 hour under stirring condition of 65°C and 500rpm to obtain carboxyl-PEG-amino modified Fe 3 o 4 composite nanoparticles.

[0180] 5. Concentrate the reaction solution in step 4 by suspension steaming to obtain a concentrated solution, and use a 3500 dialysis bag to dialyze the concentrated solution for 72 hours to obtain Fe with an iron...

Embodiment 2

[0183] Example 2 Sample 2 # preparation of

[0184] 1. Add 4.325g FeCl 3 .6H 2 O and 2.386 g FeCl 2 .4H 2 O was mixed and dissolved in 300mL water; concentrated nitric acid solution (9ml, 16M) was added dropwise, marked as mixed solution A;

[0185] 2. Quickly add 60 mg of carboxyl-PEG-amino powder to the mixed solution A, mix quickly, and mark it as mixed solution B;

[0186] 3. Rapidly raise the temperature of the mixed solution B to 85°C, and pass it into Ar for protection, add ammonia solution (500ml, volume percentage=20%) dropwise, adjust the pH value to 11, and the solution turns black rapidly;

[0187] 4. Continue to react for 2 hours under stirring conditions of 85°C and 500rpm to obtain carboxyl-PEG-amino modified γ-Fe 2 o 3 composite nanoparticles.

[0188] 5. Concentrate the reaction solution by suspension steaming to obtain a concentrated solution, and use a 3500 dialysis bag to dialyze the concentrated solution for 72 hours to obtain γ-Fe with an iron conce...

Embodiment 3

[0191] Example 3 Sample 3 # preparation of

[0192] 1. Add 4.325g FeCl 3 .6H 2 O, 2.386g FeCl 2 .4H 2 O and 0.58g ZnSO 4 .7H 2 O was mixed and dissolved in 300mL water; concentrated nitric acid solution (9ml, 16M) was added dropwise, marked as mixed solution A;

[0193] 2. Quickly add 60 mg of carboxyl-PEG-amino powder to the mixed solution A, mix quickly, and mark it as mixed solution B;

[0194] 3. Rapidly raise the temperature of the mixed solution B to 65°C, and pass it into Ar for protection, add ammonia solution (500ml, volume percentage=20%) dropwise, adjust the pH value to 11, and the solution turns black rapidly;

[0195] 4. Continue the reaction for 1 hour at 65°C and 500rpm stirring to obtain carboxyl-PEG-amino modified Zn 0.2 Fe 2.8 o 4 Doped composite nanoparticles.

[0196] 5. Concentrate the reaction solution by suspension steaming to obtain a concentrated solution. Use a 3500 dialysis bag to dialyze the concentrated solution for 72 hours to obtain Zn...

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Abstract

The application discloses a magnetic nano composite material, and a preparation method and application of the material, and belongs to the field of medical materials. The magnetic nano composite material comprises magnetic nanoparticles and a hydrophilic compound layer coated outside the magnetic nanoparticles, the magnetic nanoparticles are iron oxides, the particle size of the magnetic nanoparticles is 0.1-20 nm, the particle size of the magnetic nano composite material is 0.5-300 nm, and the longitudinal relaxation rate r1 of the magnetic nano composite is >= 20 mM-1s-1. The provided magnetic nano composite material can be used as a contrast material, and can be used in the aspects of magnetic resonance imaging contrast agents, targeted drugs, cell separation, etc.

Description

technical field [0001] The application relates to a nanocomposite material and its preparation method and application, belonging to the field of medical materials. Background technique [0002] with Fe 3 o 4 The representative ferrite nanomaterial (USPIO) can be used as an MRI T2 contrast agent, such as the marketed drugs Feridex and Resovist. However, T2 contrast agents belong to negative contrast agents (enhanced dark signal function, the lesion area appears black / dark, and surrounding normal tissues appear white / bright). Lesion areas such as sclerotic plaques) are easily confused with some special areas (such as hemorrhage, calcification, or metal deposition); at the same time, due to the high magnetic moment of this type of contrast agent, it is easy to induce fluctuations in the local magnetic field, resulting in excessive marking of some areas. It is exaggerated and may blur the image, which is called "flowering effect" in clinical diagnosis; therefore, the imaging ...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/18A61K49/22B82Y5/00B82Y20/00B82Y25/00B82Y30/00B82Y40/00H01F1/34A61K47/68A61K47/69
CPCA61K49/0002B82Y5/00B82Y25/00B82Y30/00B82Y20/00B82Y40/00A61K49/0058A61K49/0093A61K49/1875A61K49/225A61K47/6931A61K47/68H01F1/344
Inventor 陈天翔马雪华任文智吴爱国
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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