A nanoparticle photothermal conversion material based on iron and dopamine coordination and its preparation method and application

Abstract

The invention belongs to the technical field of light-to-heat conversion materials, and discloses a nano-particle light-to-heat conversion material based on the coordination of iron and dopamine, a preparation method and an application thereof. The preparation method comprises the following steps: firstly, a nano-scale iron-based metal-organic framework is prepared by a hydrothermal synthesis method; then, through the coordination of the phenolic hydroxyl group on the dopamine and the iron on the iron-based metal-organic framework, the dopamine is The role of the bond is combined in the nanoscale iron-based metal-organic framework to obtain a nanoparticle photothermal conversion material based on the coordination of iron and dopamine. The material can be well applied in photothermal therapy drug preparation, photoacoustic imaging, nuclear magnetic imaging, drug loading or functional modification.

Description

technical field [0001] The invention belongs to the technical field of light-to-heat conversion materials, in particular to a nano-particle light-to-heat conversion material based on iron and dopamine coordination and its preparation method and application. Background technique [0002] As one of the important methods for constructing nanomaterials, chemical self-assembly has been widely concerned and applied in molecular catalysis, energy materials, surface engineering, especially in the fields of life science and nanomedicine. In the process of self-assembly, basic structural units organize or aggregate into a stable structure through non-covalent interactions. Compared with hydrogen bonds, π–π interactions, electrostatic interactions, and dipole interactions, transition metal-ligand coordination interactions have attracted extensive attention due to their ease of design and control. Chemical self-assembly combines the abundant reactivity of transition metal ions with hig...

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Problems solved by technology

[0006] However, the current research is more focused on using the properties of the precursor raw materials to construct nanoparticles. The function of the synthesized nanoparticles depends on the properties of the precursor compounds, and it is difficult to realize the development and application of new functions, or to combine photosensitizers or Thermosensitizers and chemotherapeutic drugs loaded inside nanomaterials

These methods usually require relatively complicated synthesis steps, high energy consumption, and the photothermal conversion performance and therapeutic ability of materials are more dependent on the loading capacity of nanomaterials and the amount of loaded drugs.

At the same time, an overly complex construction scheme may introduce more biotoxic components, which limits its further application in the biomedical field

In addition, methods based on the coordination of iron and polyphenols to form nanoparticles have been partially reported (Naturecommunications, 2015, 6, 8003; Advanced healthcare materials, 2016, 5, 772; Nanoscale, 2017, 9, 12609; International Journal of Nanomedicine, 2017, 12, 7207; Small, 2018, 14, 1702700), however, this type of material does not have a stable coordination structure, and it needs to add a large amount of stabilizer to form nanoparticles during the synthesis process, so it is difficult to Morphology and particle size control

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