Circulating miRNA and carcino-embryonic miRNA marker related to pan-tumor auxiliary diagnosis, and application of circulating miRNA and carcino-embryonic miRNA marker

An auxiliary diagnosis and marker technology, applied in the fields of genetic engineering and oncology, can solve the problems of incompletely consistent research results

Active Publication Date: 2020-06-16
朱伟
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However, due to differences in research methods and included po...

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  • Circulating miRNA and carcino-embryonic miRNA marker related to pan-tumor auxiliary diagnosis, and application of circulating miRNA and carcino-embryonic miRNA marker
  • Circulating miRNA and carcino-embryonic miRNA marker related to pan-tumor auxiliary diagnosis, and application of circulating miRNA and carcino-embryonic miRNA marker
  • Circulating miRNA and carcino-embryonic miRNA marker related to pan-tumor auxiliary diagnosis, and application of circulating miRNA and carcino-embryonic miRNA marker

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[0039] The inventor collected a large number of pan-tumor patients from the First Affiliated Hospital of Nanjing Medical University from 2010 to 2018 (including: nasopharyngeal cancer, thyroid cancer, esophageal cancer, lung squamous cell carcinoma, lung adenocarcinoma, cardia cancer, gastric adenocarcinoma , pancreatic cancer, colon cancer, rectal cancer, prostate cancer, breast cancer, endometrial cancer, cervical cancer and ovarian cancer) as well as serum and plasma samples from newborn umbilical cord blood and normal physical examination population. A total of 3831 tumor samples (2050 serum and 1781 plasma samples), 248 cord blood samples (120 serum samples and 128 plasma samples) and matched normal adult controls (2119 serum samples) were selected. and 2029 plasma samples) samples were used as experimental samples for the initial screening of Exiqon miRNAqPCR panel chip and subsequent series of qRT-PCR verification. The selected patients' serum and plasma samples were al...

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Abstract

The invention discloses a circulating miRNA marker and a carcino-embryonic miRNA marker related to pan-tumor auxiliary diagnosis and application of the circulating miRNA marker and the carcino-embryonic miRNA marker. The circulating miRNA marker and the carcino-embryonic miRNA marker are taken as novel biomarkers and have the characteristics of being good in stability, minimally invasive, easy toobtain and high in sensitivity and specificity. Development and utilization of the molecular markers provide a new direction for diagnosis and further treatment of various diseases including tumors. According to the invention, the generic tumor circulating miRNA marker and the carcino-embryonic miRNA marker with clinical diagnosis potential can be obtained in a more targeted manner. Researches prove the reliability and repeatability of the group of miRNAs as noninvasive markers for diagnosing pan-tumors.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a circulating miRNA and carcinoembryonic miRNA marker related to pan-tumor auxiliary diagnosis and application thereof. Background technique [0002] Cancer is one of the leading causes of death worldwide. In recent years, although the molecular mechanisms and clinical features of cancer have been better understood and more treatments and methods have been developed, the prognosis of cancer patients is still poor. Due to the lack of obvious symptoms and sufficiently sensitive biomarkers, many patients were diagnosed at an advanced stage and lost the opportunity for surgery. Early detection and intervention are key strategies to improve long-term outcomes of cancer patients. Today, pathological examination of tissue samples remains the gold standard for diagnosing cancer. However, these methods rely too much on the experience of the tester, and their invasive dete...

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 朱伟周鑫刘平陈彦丁强夏添松高峰邹璇单霞朱丹霞徐德文
Owner 朱伟
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