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Black phosphorus functionalized injectable hydrogel, preparation method and application thereof

A functionalized water-injection technology, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems that it is difficult to maximize the photothermal/magnetic thermal therapy, the safety is difficult to be guaranteed, and the aggravation of internal and external problems is achieved. Realize the effect of photothermal therapy, strong infrared absorption ability, and promote new bone formation

Inactive Publication Date: 2020-06-12
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the conventional 3D stent material cannot make it match well with the topological structure and microscopic morphology of the lesion. When the light / magnetic stimulation stent is added, the stent cannot effectively contact the target site, so it is naturally difficult to achieve photothermal / magnetic heat therapy. At the same time, it is difficult to guarantee the safety of photothermal / magnetothermal conversion particles to the normal tissues of the organism; in addition, this surgical implantation of exogenous materials into the lesion will be accompanied by a large range of trauma However, the additional second operation area is not only inconvenient to operate, but also prone to the risk of infection in the operation area, which in turn aggravates internal and external injuries

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Dissolve 0.50 g of sodium alginate in ultrapure water, and stir magnetically for 30 minutes at room temperature to form a uniform viscous liquid;

[0034] (2) Under magnetic stirring, the black phosphorus quantum dots prepared by the liquid stripping method combined with the ultrasonic degradation method are added in the solution of step (1) according to a mass ratio of 0.25%, to form a uniform mixed solution, and the stirring time is 30min;

[0035] (3) transfer the mixed solution of step (2) to a specific mold by injection with a medical syringe, so that the mixed solution covers the mold cavity;

[0036] (4) Then inject an appropriate amount of 1moL / mL calcium ion solution into the above solution, so that the mixed solution in step (3) can be transformed into gel state BPQDs / SA in situ.

Embodiment 2

[0038] (1) Dissolve 0.50 g of sodium alginate in ultrapure water, and stir magnetically for 30 minutes at room temperature to form a uniform viscous liquid;

[0039] (2) Under magnetic stirring, the black phosphorus quantum dots prepared by the liquid stripping method combined with the ultrasonic degradation method are added in the solution of step (1) according to a mass ratio of 0.5%, to form a uniform mixed solution, and the stirring time is 30min;

[0040] (3) transfer the mixed solution of step (2) to a specific mold by injection with a medical syringe, so that the mixed solution covers the mold cavity;

[0041](4) Then inject 1moL / mL calcium ion solution into the above solution, so that the mixed solution in step (3) can be transformed into gel state BPQDs / SA in situ.

Embodiment 3

[0043] (1) Dissolve 0.75 g of sodium alginate in ultrapure water, and stir magnetically for 30 minutes at room temperature to form a uniform viscous liquid;

[0044] (2) Under magnetic stirring, the black phosphorus quantum dots prepared by the liquid stripping method combined with the ultrasonic degradation method are added in the solution of step (1) according to a mass ratio of 1%, to form a uniform mixed solution, and the stirring time is 30min;

[0045] (3) transfer the mixed solution of step (2) to a specific mold by injection with a medical syringe, so that the mixed solution covers the mold cavity;

[0046] (4) Then inject 1moL / mL calcium ion solution into the above solution, so that the mixed solution in step (3) can be transformed into gel state BPQDs / SA in situ.

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Abstract

The invention provides black phosphorus functionalized injectable hydrogel, and a preparation method and an application thereof. Black phosphorus quantum dots and a sodium alginate matrix are mixed byadopting an ionic crosslinking method, and then a calcium ion liquid is injected into a mixed liquid so that the mixed liquid is converted into a gel state from a liquid state in situ. BPQDs providedby the invention have a high infrared absorption capability and have a good photothermal effect, tumor cells can be effectively killed, the BPQDs can be subjected to an oxidative hydrolysis reactionunder an illumination effect, the obtained phosphorus ions have high safety and no toxicity on organisms, and a phosphorus source can be provided for biological mineralization of local cells so as topromote osteogenesis.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an injectable hydrogel functionalized with black phosphorus, a preparation method and application thereof. Background technique [0002] Lesions such as osteosarcoma and breast cancer bone metastasis are complex problems often faced in orthopedic clinical treatment. Benign bone tumors are generally easy to cure, while malignant bone tumors are difficult to be effectively treated due to their strong destructiveness; Serious problems such as bone deformation and fractures are induced. At present, in the scientific research community, the treatment of osteosarcoma and breast cancer bone metastases is more about mechanically implanting functional tissue engineering scaffold materials into the lesion site through surgery, and under the action of external stimuli, the killing effect is achieved. The effect of killing tumors (document Advanced Materials, 2018, 30(10): 17...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/20A61L27/50A61L27/52A61L27/54
CPCA61L27/12A61L27/20A61L27/50A61L27/52A61L27/54A61L2300/112A61L2300/416A61L2400/06A61L2430/02C08L5/04
Inventor 李建树赵耀许晓洋丁春梅
Owner SICHUAN UNIV
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