A kind of preparation method of reinforced modified carboxymethyl chitosan hydrogel

A technology of carboxymethyl chitosan water and carboxymethyl chitosan, which is applied in the field of preparation of enhanced modified carboxymethyl chitosan hydrogel, can solve the problems of poor mechanical properties, harsh conditions, and high product brittleness. Achieve the effects of enhancing mechanical properties and thermal stability, enhancing performance and overcoming brittleness

Active Publication Date: 2022-03-04
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the hydrogel prepared by chitosan and its derivatives has a wide range of uses in the medical field, the existing defects of this material are: the strength of the finished product is not enough, the mechanical properties of the film are poor, the brittleness is large, and the absorption Liquid penetration is not strong, so enhancement modification is required
In the past, although some literatures reported the enhancement and modification of carboxymethyl chitosan, the methods were complicated, the conditions were harsh, the preparation was difficult, the product was brittle, and the performance as a medical dressing on the skin was not good.

Method used

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  • A kind of preparation method of reinforced modified carboxymethyl chitosan hydrogel
  • A kind of preparation method of reinforced modified carboxymethyl chitosan hydrogel
  • A kind of preparation method of reinforced modified carboxymethyl chitosan hydrogel

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Experimental program
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Effect test

Embodiment 1

[0033] Step 1): Synthesis of 3-aminopropyl polyhedral oligomeric silsesquioxane: Measure 50ml of 3-aminopropyltriethoxysilane and add it to a 250ml reaction bottle, then add 25ml deionized water, 10ml ethanol, Add 2ml of acetonitrile and 1.2ml of tetraethylammonium hydroxide into the reaction flask in turn, stir the solution with a magnetic stirrer at room temperature to fully mix the solution, raise the temperature to 55°C, react in an oil bath for 30 hours, then cool down to 20°C , pour the sample into a large beaker, pour tetrahydrofuran 4 times the volume of the reaction solution, seal it and let it stand for precipitation at 10°C overnight, filter to obtain a white solid product, dry the product in a vacuum oven at 40°C for 48 hours, and take out Grind and pulverize with a mortar, and sieve with a 100-mesh sieve to obtain powdery 3-aminopropyl polyhedral oligomeric silsesquioxane, code-named APOS.

[0034] Step 2): Preparation of carboxymethyl chitosan (CS) solution: Diss...

Embodiment 2

[0038] With embodiment 1, but change step 4) in the 3-aminopropyl polyhedral oligomeric silsesquioxane consumption is 0.7g, all the other operations are identical, obtain strengthening modified carboxymethyl chitosan hydrogel, numbering is CSAP- 2.

Embodiment 3

[0040] With embodiment 1, but change step 4) in the 3-aminopropyl polyhedral oligomeric silsesquioxane consumption is 0.8g, all the other operations are identical, obtain strengthening modified carboxymethyl chitosan hydrogel, numbering is CSAP- 3.

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Abstract

The present invention relates to a kind of preparation method of reinforced modified carboxymethyl chitosan hydrogel, first prepare powdery 3-aminopropyl polyhedron oligomeric silsesquioxane, then add in the solution of carboxymethyl chitosan , and then add polyethylene glycol diglycidyl ether solution, stir evenly, transfer the solution into a mold, and place it in an electric heating constant temperature drying oven for constant temperature reaction for 1 hour to obtain enhanced modified carboxymethyl chitosan hydrogel. 3-aminopropyl polyhedral oligomeric silsesquioxane is covalently linked to carboxymethyl chitosan and uniformly distributed in the carboxymethyl chitosan hydrogel system, thereby enhancing the mechanical properties and thermal stability of the hydrogel sex.

Description

technical field [0001] The invention relates to a preparation method and application of reinforced modified carboxymethyl chitosan hydrogel, and belongs to the technical field of polymer material modification and application thereof. Background technique [0002] Hydrogel is a swollen system composed of a three-dimensional network structure composed of hydrophilic polymers and solvent water. It is between liquid and solid. It not only has the stability of solid, but also has certain flexibility and elasticity. It can swell in water and maintain a large amount of water without dissolving or melting, and small molecular substances can diffuse or exchange in it, so it is widely used in the fields of drug controlled release, immobilized enzymes, biological material cultivation and purification, medical dressings, etc. . [0003] Chitosan is the deacetylated product of chitin, the second largest biological resource after cellulose in nature, and the only cationic aminopolysaccha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L83/08C08L71/02A61L26/00
CPCC08J3/075C08J3/24A61L26/0023A61L26/0019A61L26/008C08J2305/08C08J2483/08C08J2471/02C08L5/08C08L71/02C08L83/08
Inventor 倪才华张丽萍刘仁张旭
Owner JIANGNAN UNIV
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