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Preparation method of stable water-in-oil type Pickering emulsion based on phytosterol

A phytosterol, water-in-oil type technology is applied in the directions of emulsion delivery, skin care preparations, medical preparations of inactive ingredients, etc., and achieves the effects of low production cost, simple production process and improved stability.

Active Publication Date: 2020-04-03
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason is the lack of food-grade particles that can be used to stabilize water-in-oil Pickering emulsions

Method used

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  • Preparation method of stable water-in-oil type Pickering emulsion based on phytosterol
  • Preparation method of stable water-in-oil type Pickering emulsion based on phytosterol
  • Preparation method of stable water-in-oil type Pickering emulsion based on phytosterol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) According to the solid-to-liquid ratio of 1:100 at normal temperature, phytosterols (purchased from Shaanxi Haisifu Biological Engineering Co., Ltd., wherein the total sterol content ≥ 95%, β-sitosterol 55%, campesterol 30%, stigmasterol 10% %, brassicasterol 0.49%) is dispersed in dehydrated alcohol, then 45 ℃ of heating 5min, obtains the ethanol solution of phytosterol; In the described solid-liquid ratio, the solid dosage unit is kilogram, and the liquid dosage unit is liter.

[0043](2) The ethanol solution of the above-mentioned phytosterols is mixed with water at a volume ratio of 5:5, and simultaneously sheared and homogenized at 10,000 rpm for 2 minutes, and the ethanol is removed by rotary evaporation, and concentrated to 3% w / v to obtain a high-concentration plant A water dispersion of sterol particles; the unit of w is kilogram, and the unit of v is liter;

[0044] (3) The water dispersion of the above-mentioned phytosterol particles is mixed with corn oi...

Embodiment 2

[0046] (1) According to the solid-to-liquid ratio of 1:100 at normal temperature, phytosterols (purchased from Shaanxi Haisifu Biological Engineering Co., Ltd., wherein the total sterol content ≥ 95%, β-sitosterol 55%, campesterol 30%, stigmasterol 10% %, brassicasterol 0.49%) is dispersed in dehydrated alcohol, then 85 ℃ of heating 5min, obtains the ethanol solution of phytosterol; In the described solid-liquid ratio, the solid dosage unit is kilogram, and the liquid dosage unit is liter.

[0047] (2) The ethanol solution of the above-mentioned phytosterol is mixed with water at a volume ratio of 5:5, and simultaneously sheared and homogenized at 8000 rpm for 4min, and the ethanol is removed by rotary evaporation, and concentrated to 2% w / v to obtain a high-concentration phytosterol Water dispersion of particles; the unit of w is kilogram, and the unit of v is liter.

[0048] (3) The above-mentioned aqueous dispersion of high-concentration phytosterol particles is mixed with ...

Embodiment 3

[0051] (1) According to the solid-to-liquid ratio of 1:100 at normal temperature, phytosterols (purchased from Shaanxi Haisifu Biological Engineering Co., Ltd., wherein the total sterol content ≥ 95%, β-sitosterol 55%, campesterol 30%, stigmasterol 10% %, brassicasterol 0.49%) is dispersed in dehydrated alcohol, then 45 ℃ of heating 5min, obtains the ethanol solution of phytosterol; In the described solid-liquid ratio, the solid dosage unit is kilogram, and the liquid dosage unit is liter.

[0052] (2) The ethanol solution of the above-mentioned phytosterols is mixed with water at a volume ratio of 3:7, and simultaneously sheared and homogenized at 1000 rpm for 2 min, the ethanol is removed by rotary evaporation, and concentrated to 3% w / v to obtain high-concentration phytosterols Water dispersion of particles; the unit of w is kilogram, and the unit of v is liter.

[0053] (3) The above-mentioned aqueous dispersion of high-concentration phytosterol particles is mixed with dod...

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Abstract

The invention belongs to the field of water-in-oil type emulsion, and discloses stable water-in-oil type Pickering emulsion based on phytosterol, and a preparation method and application of the stablewater-in-oil type Pickering emulsion based on phytosterol. The water-in-oil type Pickering emulsion is prepared by the following method including the steps of dispersing the phytosterol in anhydrousalcohol, performing heating for dissolving to obtain an ethanol solution of the phytosterol, then mixing the obtained ethanol solution of the phytosterol with water, then removing ethanol to obtain aqueous dispersion liquid of phytosterol granules, and performing mixing and homogenizing on the aqueous dispersion liquid and an oil phase to obtain the water-in-oil type Pickering emulsion; or dryingthe aqueous dispersion liquid to obtain phytosterol powder, dispersing the phytosterol powder into the oil phase, then mixing the oil phase with the phytosterol powder, with the water, and then performing homogenizing to obtain the water-in-oil type Pickering emulsion. Compared with a preparation method of a traditional water-in-oil type granule stabilizing agent, the method disclosed by the invention has the advantages that without adding a surfactant or chemical modification, the water-in-oil type Pickering emulsion good in stability can be produced, the technology is simple, and industrialization is easy to realize.

Description

technical field [0001] The invention belongs to the field of water-in-oil emulsions, in particular to a phytosterol-based stable water-in-oil Pickering emulsion and a preparation method and application thereof. Background technique [0002] Water-in-oil emulsion is an important type of emulsion system, which has broad application prospects in food, chemical and other related fields. For example, margarine is a water-in-oil emulsion used to replace animal butter, and most cosmetic creams are also water-in-oil emulsions. Water-in-oil emulsion is also a good embedding carrier for water-soluble active substances. [0003] Traditionally, the formation of water-in-oil emulsions requires the use of a large amount of surfactants, which creates environmental and safety issues. Emulsions based on particle stabilization (ie, Pickering emulsions) have the advantages of less emulsifier dosage, high emulsion stability and no surfactant. At present, most of the particles used to stabili...

Claims

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Application Information

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IPC IPC(8): A23L33/11A61K8/06A61K8/63A61K9/107A61K47/28A61Q19/00
CPCA23L33/11A61K8/064A61K8/63A61Q19/00A61K9/107A61K47/28A61K2800/10
Inventor 刘付蓝漫钰欧仕益汪勇郑洁黄才欢
Owner JINAN UNIVERSITY
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