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Novel bone repair product and preparation method thereof

A new type of bone repair technology, applied in prosthesis, tissue regeneration, medical science, etc., to achieve great reactivity, enhance bone repair ability, and inhibit bone resorption

Active Publication Date: 2021-03-23
BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main purpose of the present invention is to overcome the defects of existing bone repair products, and provide a new bone repair product containing regenerative medical materials and its preparation method

Method used

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  • Novel bone repair product and preparation method thereof
  • Novel bone repair product and preparation method thereof
  • Novel bone repair product and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0046] Preferably, the preparation method of the above-mentioned phosphate functionalized gelatin comprises:

[0047] Step 1, preparation of phosphonate-gelatin mixture: phosphonate (such as: bisphosphonate, pamidronate, alendronate, risedronate, ibandronate, Zoledronate) was dissolved in physiological saline, and then gelatin was added to prepare a phosphonate-gelatin mixture.

[0048] Step 2. Swelling and dispersion: heat and dissolve the above-mentioned phosphonate-forming gelatin mixture in a hot water bath at 50-55°C (can be: 50, 51, 52, 53, 54, 55°C), and continue stirring to swell for 0.5- 5h (can be 0.5, 1, 2, 2.5, 3, 4, 5h), then add glacial acetic acid to adjust the pH value to 1-5, and obtain the mixed solution after adjusting the pH value; then add surfactant, and then ultrasonically disperse for 1 - 40 min (can be 1, 5, 10, 15, 20, 25, 30, 40 min), preferably 20 min, to obtain a suspension.

[0049] The surfactant is preferably a nonionic surfactant, more prefer...

Embodiment 1-15

[0063] The preparation method of embodiment 1-15 comprises the following steps:

[0064] (1) Weigh each raw material according to the formula of combination 1-5, see Table 1 for details, add regenerative medicine material, calcium phosphate, pyrophosphate and phosphonate functionalized gelatin according to the formula, mix the raw material Composite powder A is obtained.

[0065] (2) Then prepare acidic buffer solution B (solution B) containing hyaluronic acid according to the formula of combination 1-5, see Table 1 for details.

[0066] (3) The composite powder A and liquid B were fully mixed at a solid-liquid mass ratio of (1-3):1 for 0.5-2 minutes, and cured at 37°C and a relative humidity of 100% to obtain a new bone repair material.

[0067] Detection method:

[0068] (1) Blend a certain weight of composite powder and a certain weight of liquid with a spatula to form a uniform slurry, that is: the above-mentioned composite powder A and liquid B according to the solid-li...

Embodiment 16

[0085] Powder: 65 parts by weight of Regesi Regenerated Silicon Type I (particle size 0.1-30 μm), 5 parts by weight of tricalcium phosphate (100-200 μm), tetracalcium phosphate (100-200 μm) 30 parts by weight;

[0086] Solution: 2g hyaluronic acid, 0.3mol citric acid, 0.5mol pyrophosphate, 1L deionized water;

[0087] The mass ratio of powder and liquid is 1:1.

[0088] For the preparation method, refer to Examples 1-15.

[0089] The properties are: initial setting time 6.5min, final setting time 24min, compressive strength 13.2MPa, porosity 3.3%.

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Abstract

The invention relates to the technical field of biomedical materials, in particular to a bone repair product containing a regenerative medical material and a preparation method thereof. The materialsinclude a powder containing a regenerative medical material, and a liquid; the powder comprises the regenerative medical material, calcium phosphate, pyrophosphate and phosphonate functionalized gelatin; and the liquid is an acidic buffer solution. The bone repair material provided by the invention contains the regenerative medical material with a large specific surface area, and has huge reactionactivity. The bone repair material contains a gelatin component which can be degraded to form micropores after being implanted into human tissues and is beneficial to promoting repair of bone defectparts. The bone repair material contains a phosphonate medicinal component which can be specifically combined with hydroxyphosphine limestone in sclerotin, inhibit osteoclast activity, and inhibit sclerotin absorption. The regenerative medical material with high biological activity, the gelatin capable of being degraded to form micropores and the phosphonate pharmaceutical ingredient have a synergistic effect, so that the effect of the bone repair material for treating bone defects and bone loss is remarkably improved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bone repair product containing regenerative medical materials and a preparation method thereof. Background technique [0002] The loss and damage of bone tissue is a common clinical disease. The human body has countless bone defects or limb incompleteness caused by trauma, aging, exercise, inflammation, tumors and congenital deformities. Therefore, there is a great demand for bone repair materials . With the advancement of social civilization, economic development, and increasing living standards, human beings attach great importance to their own medical rehabilitation. At the same time, the social population is increasing rapidly, a large number of vehicles are emerging, the pace of work and life is accelerating, diseases, natural disasters, traffic accidents, sports injuries and work injuries occur frequently, and local wars, etc., have caused a sharp increase i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/22A61L27/12A61L27/04A61L27/10A61L27/20A61L27/54A61L27/56A61L27/58
CPCA61L27/047A61L27/10A61L27/12A61L27/20A61L27/222A61L27/54A61L27/56A61L27/58A61L2300/402A61L2300/412A61L2430/02C08L5/08
Inventor 胡方仇越秀王健郭创洲
Owner BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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