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Etomidate nano preparation and preparation method thereof

A technology of etomidate and nano-preparation, applied in nanotechnology, nanotechnology, nanomedicine and other directions, can solve the problems of unusable and unfavorable preservation of nutrients, and achieve the effects of easy storage, non-irritant allergy and high safety.

Active Publication Date: 2020-03-24
SOUTHWEST MEDICAL UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been reported that propylene glycol can cause side effects such as acidosis, coma, seizures, hyperosmolarity, and arrhythmia; etomidate fat emulsion cannot be used in patients who are allergic to soybeans, and caution should also be used in obese or hyperlipidemia patients. And due to the presence of nutrients, it is not conducive to preservation
[0004] Therefore, develop a kind of novel etomidate preparation, the side effect that promotes drug minimizes and avoids the problem of existing preparation, still is a big challenge to etomidate clinical application

Method used

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  • Etomidate nano preparation and preparation method thereof
  • Etomidate nano preparation and preparation method thereof
  • Etomidate nano preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Nano formulation of etomidate of the present invention

[0033] (1) Weigh 100mg lecithin and 10mg etomidate into 2 3ml test tubes, numbered a and b.

[0034] (2) Add 1ml of chloroform to the two test tubes a and b respectively, shake well and shake well until no solid particles remain on the tube wall.

[0035] (3) Inject all the solutions in a and b2 test tubes into a rotary evaporator at 25°C and maintain a constant speed of 60r / min to remove volatile solvents so that liposomes form a lipid dry film on the spherical wall.

[0036] (4) After the film is formed, continue to bubbling in nitrogen for 10 minutes to remove residual volatile organic solvents.

[0037] (5) Add 5 ml of phosphate buffered saline (PBS) with a pH of 7.35, shake and shake well until there are no solid particles remaining on the tube wall. After it is completely dissolved, a phosphate buffer solution with a concentration of 2 mg etomidate per ml is formed, and then the mixed solution is poured int...

Embodiment 2

[0039] Example 2 Nano formulation of etomidate of the present invention

[0040] (1) Weigh 90 mg of lecithin, 10 mg of pluronic P123, and 10 mg of etomidate into three 3 ml test tubes, numbered a, b, and c.

[0041] (2) Add 1ml of chloroform to the 3 test tubes of a, b, and c, shake well, and shake well until there are no solid particles on the tube wall.

[0042] (3) Inject all the solutions in the 3 test tubes of a, b, and c into the rotary evaporator at 25°C and maintain a constant speed of 60r / min to remove volatile solvents so that the liposomes form a lipid dry film on the spherical wall.

[0043] (4) After the film is formed, continue to bubbling in nitrogen for 10 minutes to remove residual volatile organic solvents.

[0044] (5) Add 5 ml of pH 7.35 phosphate buffered saline (PBS), shake and shake well until there are no solid particles remaining on the tube wall. When completely dissolved, a phosphate buffer solution with a concentration of 2 mg etomidate per ml is formed, and...

Embodiment 3

[0046] Example 3 Nano formulation of etomidate of the present invention

[0047] (1) Weigh 80mg lecithin, 20mg pluronic P123, and 10mg etomidate into 3 3ml test tubes, numbered a, b, c

[0048] (2) Add 1ml of chloroform to the 3 test tubes of a, b, and c, shake well, and shake well until there are no solid particles on the tube wall.

[0049] (3) Inject all the solutions in the 3 test tubes of a, b, and c into the rotary evaporator at 25°C and maintain a constant speed of 60r / min to remove volatile solvents so that the liposomes form a lipid dry film on the spherical wall.

[0050] (4) After the film is formed, continue to bubbling in nitrogen for 10 minutes to remove residual volatile organic solvents.

[0051] (5) Add 5 ml of phosphate buffered saline (PBS) with a pH of 7.35, shake and shake well until there are no solid particles remaining on the tube wall. When completely dissolved, a phosphate buffer solution with a concentration of 2 mg etomidate per ml is formed, and then the mi...

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Abstract

The invention provides an etomidate nano preparation. The etomidate nano preparation is prepared from the following raw materials in parts by weight: 10 parts of etomidate, 0-30 parts of pluronic and70-100 parts of lecithin. The etomidate nano preparation disclosed by the invention has the advantages of high safety, low toxicity, no irritating allergy, good biocompatibility, good bioavailabilityand high stability, and has practical application and popularization values.

Description

Technical field [0001] The invention relates to an etomidate nano preparation and a preparation method thereof. Background technique [0002] Liposomes, also called liposomes, are a new type of drug carrier with a targeted drug delivery function. They have a phospholipid bilayer structure similar to the cell membrane of organisms (including humans). In recent decades, it has been mainly used to develop new drugs, especially targeted chemotherapeutics. Preparations such as liposomes and polymer micelles based on hydrophilic nanocarriers have been actively researched to improve the water solubility of hydrophobic drugs, achieve selective drug biodistribution and control drug release, thereby improving efficacy and reducing drug side effects However, liposomes have not been used as carriers for the preparation of etomidate. [0003] Etomidate is a non-barbiturate intravenous anesthetic. It is a white crystal or crystalline powder. It mainly acts on the high spinal cord and the senso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/24A61K47/10A61K31/4174A61P23/00B82Y5/00
CPCA61K9/127A61K47/24A61K47/10A61K31/4174A61P23/00B82Y5/00
Inventor 刘浩张羽寒王斯娇袁行陈晶晶石心雨
Owner SOUTHWEST MEDICAL UNIVERISTY
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