Ketoprofen intermediate, preparation method and applications thereof

A technology of ketoprofen and asana, which is applied in the field of ketoprofen intermediates and its preparation, can solve the problems of highly toxic reaction reagents, harsh reaction conditions, and high production costs

Inactive Publication Date: 2020-03-03
JIANGSU RUIKE MEDICAL SCI & TECH CO LTD
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] In order to solve the above-mentioned technical problems, the present invention provides a ketoprofen intermediate, which is used as a raw material to prepare ketoprofen and its general formula compound, which eliminates the high production cost existing in the existing preparation process. , The reaction reagents are highly toxic, there are many reaction by-products, and the reaction conditions are harsh, so it is suitable for industrial production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ketoprofen intermediate, preparation method and applications thereof
  • Ketoprofen intermediate, preparation method and applications thereof
  • Ketoprofen intermediate, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0178] Embodiment 1: the preparation of formula II compound

[0179]

[0180] After adding compound of formula I (13.0g, 0.057mol), DMF (68ml) and water (13.6ml) into the reaction flask, stirring and dissolving, the ozone reaction was started, and the reaction solution gradually became shallower and exothermic, and the temperature rose to 40 ℃ or so. After about 1 hour, a sample was taken for testing. After the raw material disappears, turn off the ozone, change to air or nitrogen for 10-20 minutes, add an appropriate amount of ethyl acetate hydrate, stir, stand still, separate layers, then extract with a small amount of ethyl acetate, and wash the organic layer with water. The organic layer was concentrated to dryness under reduced pressure. 14.6 g of the compound of formula II was obtained, with a content of 93.2% and a yield of 91.9%.

Embodiment 2

[0181] Embodiment 2: the preparation of formula III compound

[0182]

[0183] Add formula II compound (10g, 0.038mol), DMF (50ml), K 2 CO 3 (11g, 0.080mol), start to heat up after stirring evenly, when the temperature is 80°C, add a DMF solution of methyl cyanoacetate (6.6g, 0.066mol) dropwise, and after dripping at 80°C for 30 minutes, take a sample to detect the central control, when After the raw materials disappeared, the temperature was lowered to about 10°C, and the pH was adjusted to 1-2 with 1N dilute HCl, extracted with ethyl acetate, the organic layer was washed with an appropriate amount of water, and concentrated to dryness under reduced pressure to obtain 12.1 g of the compound of formula III, with a content of 87.3%. , yield 85%.

Embodiment 3

[0184] Embodiment 3: the preparation of formula IV compound

[0185]

[0186] Add the compound of formula III (10 g, 0.03 mol), Pd / C (50 mg) and methanol (30 ml) into a 100 ml reaction flask, and stir the reaction with hydrogen gas. After reacting at 25°C for 5 hours, sampling and testing were started. When the raw materials disappeared, suction filtration, washing with an appropriate amount of methanol, and concentration of the mother liquor to dryness under reduced pressure gave 8.97 g of the compound of formula IV, with a content of 97.2% and a yield of 96.1%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the field of medicine synthesis, particular to a ketoprofen intermediate, a preparation method and applications thereof. The preparation method comprises the following steps:carrying out a Diels-Alder reaction on p-nitrohalobenzene or o-nitrohalobenzene or a mixture of p-nitrohalobenzene and o-nitrohalobenzene as a raw material and phenylacetonitrile to form an isoxazolecompound, and sequentially carrying out an oxidation reaction, a substitution reaction, a reduction reaction, deamination, ester group removal and an acidic hydrolysis reaction to prepare ketoprofen,wherein the reaction formula is defined in the specification, X2 or the group defined in the specification is located at the ortho-position or para-position of nitro or amino, R1 is -CONR4R5, -COX1, -COOR2 or -CN, R2, R3, R4, R5 and R6 are the same or different and are H or C1-C6 alkyl, and X1 and X2 are the same or different and are F, Cl, Br or I.

Description

technical field [0001] The invention relates to the field of pharmaceutical synthesis, in particular to a ketoprofen intermediate and its preparation method and application. Background technique [0002] Ketoprofen, also known as "ketoprofen", was first listed in France in 1973, and then officially entered China in the 1980s. Now it has developed various dosage forms such as oral tablets, patches, and diaphragms. And has been widely used at home and abroad. The drug is a non-steroidal anti-inflammatory analgesic with anti-inflammatory, antipyretic and analgesic effects, and is mainly used for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and gout wait. Its analgesic effect is superior to similar drugs and lasts for a long time. Its toxic and side effects are small, and the adverse reactions are generally intestinal and stomach discomfort or rash, headache, and tinnitus. [0003] The chemical name of ketoprofen is 3-be...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/84C07C51/08C07C253/30C07C255/41C07C255/42C07C255/40C07C201/06C07C205/45
CPCC07C59/84C07C51/08C07C253/30C07C255/41C07C255/42C07C255/40C07C201/06C07C205/45
Inventor 高照波刘声民王长发郭必豹郑辉胡剀梅义将
Owner JIANGSU RUIKE MEDICAL SCI & TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap