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Osthole micro-emulsion as well as preparation method and application of osthole micro-emulsion

A technology of osthole and microemulsion, which is applied in the field of medicine, can solve the problems of high concentration and achieve good physical stability

Active Publication Date: 2020-01-21
SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The literature discloses that 50 μmol L -1 Osthole has a better protective effect on cells, but the concentration of osthole which has a better protective effect on cells is still relatively large. Whether the curative effect of osthole can be improved by improving the dosage form is the technology to be solved in this application question

Method used

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  • Osthole micro-emulsion as well as preparation method and application of osthole micro-emulsion
  • Osthole micro-emulsion as well as preparation method and application of osthole micro-emulsion
  • Osthole micro-emulsion as well as preparation method and application of osthole micro-emulsion

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Embodiment 1

[0049] The preparation of embodiment 1 osthole microemulsion

[0050] Mix 4.0ml castor oil with 4.0mLHS-15 as an emulsifier, and then mix it with 2.0mL polyethylene glycol 400 to make a mixed emulsifier. The oil phase was 2 mL of ethyl oleate, mixed with a mixed emulsifier, and stirred to obtain a mixture. Add 125mg of osthole to the mixture, stir to make it completely dissolved, and dilute to 25mL with pure water. Obtain osthole microemulsion mother liquor, concentration is 5mg / mL.

Embodiment 2

[0051] The preparation of embodiment 2 osthole microemulsions

[0052] Mix 4.0ml castor oil with 4.0mLHS-15 as an emulsifier, and then mix it with 2.0mL polyethylene glycol 400 to make a mixed emulsifier. The oil phase was 2 mL of ethyl oleate, mixed with a mixed emulsifier, and stirred to obtain a mixture. Add 25 mg of osthole to the mixture, stir to make it completely dissolved, and dilute to 50 mL with pure water. Obtain osthole microemulsion mother liquor, concentration is 0.5mg / mL.

Embodiment 3

[0053] The preparation of embodiment 3 osthole microemulsions

[0054] Mix 4.0ml castor oil with 4.0mLHS-15 as an emulsifier, and then mix it with 2.0mL polyethylene glycol 400 to make a mixed emulsifier. The oil phase was 2 mL of ethyl oleate, mixed with a mixed emulsifier, and stirred to obtain a mixture. Add 0.5 g of osthole to the mixture, stir to dissolve it completely, and dilute to 25 mL with pure water. Obtain osthole microemulsion mother liquor, concentration is 20mg / mL.

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to an osthole micro-emulsion as well as a preparation method and application of the osthole micro-emulsion. The osthole micro-emulsion comprises osthole and auxiliary materials, wherein the auxiliary materials comprise a mixed emulsifier, ethyl oleate and deionized water; and the mixed emulsifier comprises polyoxyethylene 35 castor oil, polyethylene glycol 15-hydroxystearate and polyethylene glycol 400. The osthole micro-emulsion has different degrees of protection effects on injured cells, and 10 [mu]mol / L of the osthole micro-emulsion has the best protection effect on cells in particular.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an osthole microemulsion, a preparation method and application thereof. Background technique [0002] Alzheimer's disease (AD) is a relatively common neurodegenerative disease that occurs in the central nervous system. Personality changes and language barriers, etc. [1] . At present, its drug treatment mainly includes cholinesterase inhibitors, memantine treatment, insulin nasal drops, application of antioxidant drugs, use of hormone replacement therapy, traditional Chinese medicine and herbal treatment, etc., as well as non-invasive brain stimulation technology, cognitive training, phototherapy, etc. and other non-drug therapies. [0003] Epidemiological investigations have shown that estrogen has a therapeutic effect on Parkinson's disease. In recent years, studies have found that osthole (osthole) has phytoestrogens-like effects, so it has potential neuroprote...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/14A61K47/10A61K47/44A61K31/37A61P25/28
CPCA61K9/1075A61K31/37A61K47/10A61K47/14A61K47/44A61P25/28
Inventor 侯雪芹郝吉福宋宜蕾
Owner SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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