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Method for preparing lyserin-based near-infrared material

A near-infrared, lyoline-based technology, used in medical preparations containing active ingredients, wave energy or particle radiation treatment materials, pharmaceutical formulations, etc., can solve the problems of weak gene carrying capacity, poor biocompatibility, etc. Secondary damage, strong antibacterial ability, beneficial to deep penetration

Pending Publication Date: 2020-01-17
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims to overcome the problems of weak gene carrying capacity and poor biocompatibility of drug carriers for tumor targeting therapy in the prior art, and provides a method for preparing a lyoline-based near-infrared material, which has relatively large topological support Chain structure, strong drug loading capacity, and certain bactericidal ability, the resulting product has good thermal stability, and the preparation process is simple

Method used

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  • Method for preparing lyserin-based near-infrared material
  • Method for preparing lyserin-based near-infrared material

Examples

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Embodiment 1

[0041] A method for preparing a phenoline-based near-infrared material, comprising the following steps: (1), synthesizing a phenoline-based monochloro-substituted perylene diacid anhydride compound: a, dissolving the perylene diacid anhydride in concentrated sulfuric acid, with a mass ratio of 1: 2.3 Until it is completely dissolved, mix evenly, complete under the condition of magnetic stirring in a nitrogen atmosphere, the volume concentration of concentrated sulfuric acid is 67%, b, the mixed solution obtained in step a is at -0.5°C, slowly add TBCA of concentrated sulfuric acid Solution, keep the reaction for 2.7h, and then detect the degree of reaction; c, when the alcohol phase appears, the chromatographic column separates the large molecular weight product, and the deionized water is purified by dialysis for 28h. , after freeze-drying, green powder is obtained, that is, lethrin-based monochloro-substituted perylene diacid anhydride compound; (2), preparation of lethrin-ba...

Embodiment 2

[0043] The difference from the above-mentioned Example 1 is that a preparation method of a phenoline-based near-infrared material comprises the following steps: (1), synthesizing a morpholine-based monochloro-substituted perylene diacid anhydride compound: a, dissolving the perylene diacid anhydride in In concentrated sulfuric acid, the mass ratio is 0.7:2.2 until it is completely dissolved, and mixed evenly. In a nitrogen atmosphere, it is completed under magnetic stirring conditions. The volume concentration of concentrated sulfuric acid is 65%. b. The mixed solution obtained in step a is kept at -1°C Next, slowly add the TBCA solution of concentrated sulfuric acid dropwise, keep the reaction for 2.5h, and then detect the degree of reaction; c, when the alcohol phase appears, the chromatographic column separates the large molecular weight product, and the deionized water is dialysis purified for 24h, and the dialysis purification part is dialysis membrane Molecular weight cut...

Embodiment 3

[0046]The difference from the above-mentioned Example 1 is that a preparation method of a phenoline-based near-infrared material comprises the following steps: (1), synthesizing a morpholine-based monochloro-substituted perylene diacid anhydride compound: a, dissolving the perylene diacid anhydride in In concentrated sulfuric acid, the mass ratio is 1.2:2.4 until it is completely dissolved, and the mixture is evenly mixed. In a nitrogen atmosphere, it is completed under the condition of magnetic stirring. The volume concentration of concentrated sulfuric acid is 70%. b. Mix the solution obtained in step a at 0°C , slowly drip the TBCA solution of concentrated sulfuric acid, keep the reaction for 3h, and then detect the degree of reaction; c, when the alcohol phase appears, the chromatographic column separates the large molecular weight product, and the deionized water is purified by dialysis for 30h, and the molecular weight cut-off of the dialysis membrane at the dialysis purif...

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Abstract

The invention relates to the field of pharmaceutical, aims to the problem that in the prior art, a tumor targeted gene therapy drug carrier is poor in gene bearing capacity and poor in biocompatibility, discloses a method for preparing a lyserin-based near-infrared material. The method comprises the following steps: (1), synthesizing a lyserin-based monochlorine-substituted perylene dianhydride compound, namely a, dissolving perylene dianhydride into concentrated sulfuric acid in a mass ratio of (0.7-1.2):(2.2-2.4); b, slowly adding dropwise a TBCA (trbromoisocyanunic acid) solution of the concentrated sulfuric acid into the mixed solution; c, when an alcohol phase occurs, performing dialysis purification by using deionized water, shading light in the process, and performing freeze dryingso as to obtain PDI; and (2) preparing a lyserin-based near-infrared material nano medicine, namely dissolving the PDI and polyethylene glycol into the deionized water according to a mass ratio of (0.8-1):(1.4-1.8), and performing ultrasonic stirring treatment. The material has a large topological branch chain structure, a strong drug bearing capacity and a certain bactericidal capability, the obtained product has good thermal stability, and the preparation process is simple.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a method for preparing a phenoline-based near-infrared material. Background technique [0002] Photothermal therapy excited by near-infrared light can effectively make up for the shortcomings of traditional cancer treatment methods, but the photostability of commonly used near-infrared organic photothermal molecules (such as cyanines, etc.) is poor, and its photodegradation will affect the stability and stability of nanostructures. Light-to-heat conversion efficiency. Therefore, the development of a new near-infrared organic photothermal reagent with high stable nanostructure and high photothermal conversion efficiency will effectively improve the treatment efficiency and medical safety of tumors. In addition, this infrared material is used as a carrier for tumor targeting therapy in vivo, so the antibacterial properties of the material are also essential. [0003] Patent No. CN20181024...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/337C08G65/331A61K41/00A61P35/00
CPCA61K41/0052A61P35/00C08G65/3318C08G65/337
Inventor 周英棠
Owner ZHEJIANG OCEAN UNIV
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