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A kind of strontium α-calcium sulfate hemihydrate/nano silver/ginsenoside-loaded sodium alginate microsphere bone substitute material and preparation method thereof

A technology of calcium sulfate hemihydrate and sodium alginate, applied in pharmaceutical formulations, prostheses, drug delivery, etc., to achieve the effect of reducing risk, good biocompatibility and degradability, and promoting repair

Active Publication Date: 2021-12-21
THE EIGHTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the deficiencies in the prior art and provide a strontium-containing α-calcium sulfate hemihydrate / nanometer silver / loaded ginsenoside sodium alginate microsphere bone substitute material and its preparation method

Method used

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  • A kind of strontium α-calcium sulfate hemihydrate/nano silver/ginsenoside-loaded sodium alginate microsphere bone substitute material and preparation method thereof
  • A kind of strontium α-calcium sulfate hemihydrate/nano silver/ginsenoside-loaded sodium alginate microsphere bone substitute material and preparation method thereof
  • A kind of strontium α-calcium sulfate hemihydrate/nano silver/ginsenoside-loaded sodium alginate microsphere bone substitute material and preparation method thereof

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Experimental program
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Embodiment 1

[0049] The preparation method of the bone substitute material described in this embodiment comprises the following steps:

[0050] (1) Preparation of strontium-doped calcium sulfate hemihydrate:

[0051] Weigh 0.05mol of Sr(OH) 2 ·8H 2 O and 0.45mol of Ca(OH) 2 Put it into a beaker, add an appropriate amount of deionized water and stir until uniform to obtain a suspension; take 0.5mol concentrated sulfuric acid and dilute to 50ml, and slowly add it dropwise into the uniformly stirred suspension at 30°C while stirring; Before the sulfuric acid is dropped, the suspension should maintain a pH ≥ 8.5; after the sulfuric acid is dropped, the suspension is stirred for 3 hours, and then filtered while it is hot, and the obtained filter residue is dried in an oven at 50°C for 4 hours, and then the obtained Sr -CaSO 4 2H 2 O is ground into 200 mesh powder, and then according to Sr-CaSO 4 2H 2 The weight ratio of O and deionized water is 0.15. Add deionized water for mixing, and r...

Embodiment 2

[0058] The preparation method of the bone substitute material described in this embodiment comprises the following steps:

[0059] (1) Preparation of strontium-doped calcium sulfate hemihydrate:

[0060] Weigh 0.05mol of Sr(OH) 2 ·8H 2 O and 0.95mol of Ca(OH) 2 Put it into a beaker, add an appropriate amount of deionized water and stir until uniform to obtain a suspension; dilute 1 mol of concentrated sulfuric acid to 50ml, and slowly add it dropwise into the stirred suspension at 28°C while stirring; Before the sulfuric acid is dropped, the suspension should keep pH ≥ 8.5; after the sulfuric acid is dropped, the suspension is stirred for 4 hours, and then filtered while it is hot, and the obtained filter residue is dried in an oven at 50°C for 4 hours, and then the obtained Sr- CaSO 4 2H 2 O was ground into 200 mesh powder, and then according to Sr-CaSO 4 2H 2 The weight ratio of O and deionized water is 0.15. Add deionized water for mixing, and react in an oven or muf...

Embodiment 3

[0067] The preparation method of the bone substitute material described in this embodiment comprises the following steps:

[0068] (1) Preparation of strontium-doped calcium sulfate hemihydrate:

[0069] Weigh 0.05mol of Sr(OH) 2 ·8H 2 O and 0.45mol of Ca(OH) 2Put it into a beaker, add an appropriate amount of deionized water and stir until uniform to obtain a suspension; take 0.5mol concentrated sulfuric acid and dilute to 50ml, and slowly add it dropwise to the uniformly stirred suspension at 32°C while stirring; Before the sulfuric acid is dropped, the suspension should maintain a pH ≥ 8.5; after the sulfuric acid is dropped, the suspension is stirred for 2 hours, and then filtered while it is hot, and the obtained filter residue is dried in an oven at 50°C for 4 hours, and then the obtained Sr -CaSO 4 2H 2 O is ground into 200 mesh powder, and then according to Sr-CaSO 4 2H 2 The weight ratio of O and deionized water is 0.15. Add deionized water for mixing, and reac...

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Abstract

The invention discloses a bone substitute material, which comprises the following components in parts by weight: 1 part of ginsenoside sodium alginate microspheres and 90-110 parts of strontium-doped calcium sulfate hemihydrate loaded with silver nanoparticles; the ginsenoside alginate In the sodium microspheres, the mass ratio of ginsenoside to sodium alginate is: ginsenoside: sodium alginate = 1:4000-12000. The invention loads ginsenosides into the natural polymer alginic acid microspheres, which can promote the proliferation, migration and osteogenic differentiation of human bone marrow stromal cells. At the same time, sodium alginate microspheres are introduced into calcium sulfate hemihydrate containing strontium, which improves The strontium calcium sulfate hemihydrate material has the problems of high brittleness and sudden release. The prepared bone substitute material is a composite artificial bone material with certain mechanical properties and drug sustained release; nano-silver is added to the bone repair material, which can reduce the Risk of inflammation due to bone infection from surgery or trauma.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a strontium-containing α-calcium sulfate hemihydrate / nanometer silver / ginsenoside-loaded sodium alginate microsphere bone substitute material and a preparation method thereof. Background technique [0002] The increase in bone defects caused by trauma, osteomyelitis, tumors, and other types of bone diseases has created an urgent need for biodegradable synthetic bone substitutes. Many inorganic materials have been studied due to their chemical similarity to the mineral phases of bone and possess properties similar to natural bone, which facilitate direct bonding with host bone and enhance osteogenesis. Among these materials, calcium sulfate α hemihydrate (commonly referred to as calcium sulfate in medical literature) has good biocompatibility, biodegradability, and osteoconduction properties, and is often used as a bone repair material. Moreover, calcium sulfate hemihydrate ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/02A61L27/04A61L27/54A61L27/50A61L27/58
CPCA61L27/20A61L27/025A61L27/047A61L27/54A61L27/50A61L27/58A61L2430/02A61L2400/12A61L2300/602A61L2300/104A61L2300/412A61L2300/41C08L5/04
Inventor 唐硕林强罗鹏
Owner THE EIGHTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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