A kind of preparation method of bamboo ginseng saponin iva butyl ester

A technology of ginseng saponins and butyl esters, applied in the production of steroids, organic chemistry, bulk chemicals, etc., can solve problems such as hindering research on the pharmacological activity of ginseng saponins IVa butyl ester, and achieve low cost and post-processing. Simple, high-yield and pure results

Active Publication Date: 2022-04-19
EAST CHINA UNIV OF SCI & TECH +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] However, so far, no chemical synthesis route has been reported for the preparation of ginseng saponin IVa butyl ester, which hinders the research on the relevant pharmacological activities of ginseng saponin IVa butyl ester

Method used

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  • A kind of preparation method of bamboo ginseng saponin iva butyl ester
  • A kind of preparation method of bamboo ginseng saponin iva butyl ester
  • A kind of preparation method of bamboo ginseng saponin iva butyl ester

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Embodiment Construction

[0039] In the following, the technology of the present invention will be described in detail in conjunction with specific implementation methods. It should be known that the following specific embodiments are only used to help those skilled in the art understand the present invention, rather than limiting the present invention.

[0040] In this embodiment, a preparation method of bamboo ginseng saponin IVa butyl ester is provided, which has the structure shown in compound 1:

[0041]

[0042] The synthetic route of the preparation method of the bamboo ginseng saponin IVa butyl ester is:

[0043]

[0044] The preparation method of described bamboo ginseng saponin IVa butyl ester, comprises the following steps:

[0045] S10: In dichloromethane or toluene solvent (add molecular sieves to remove water), make 4,6-benzylidene-protected glucosinolate and 28-glucose-modified oleanolic acid in N-iodosuccinimide and trimethylsilyl trifluoromethanesulfonate as a catalyst, react a...

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Abstract

A preparation method of bamboo ginseng saponin IVa butyl ester, after the glycosylation reaction of 4,6-benzylidene-protected glucosinolate and 28-position glucose-modified oleanolic acid to obtain the disaccharide oleanolic acid skeleton, The intermediate product is obtained after removing the protecting group and the hydroxyl oxidation reaction of the diol; the intermediate product is reacted with iodo-n-butane to obtain the bamboo ginseng saponin IVa.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a preparation method of bamboo ginseng saponin IVa butyl ester. Background technique [0002] Bamboo ginseng saponin IVa butyl ester, as an active ingredient of traditional Chinese medicine, has potential activities such as liver protection and enzyme reduction, analgesia, anti-inflammation, choleretic, immunity enhancement and anti-aging effects, and has the potential to be used to treat liver and kidney deficiency, Muscle and bone flaccidity, delayed walking in children, icteric hepatitis and nephritis edema and other diseases have good medicinal prospects. [0003] However, the currently commercially available bamboo ginsenoside IVa butyl is isolated and extracted from the fruit of Acanthopanax saponica, gardenia root and Achyranthes bidentata, and the yield is low and the process is complicated, which limits the production of bamboo ginseng saponin IVa butyl. Research and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00
CPCC07J63/008Y02P20/55
Inventor 杨友曹鹏荣晶晶杨杰
Owner EAST CHINA UNIV OF SCI & TECH
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