A rare earth nanomaterial containing polystyrene shell and its biocoupling and application

Abstract

The invention discloses a rare earth nanomaterial containing a functionalized polystyrene shell. The rare earth nanomaterial comprises a core, a silica shell and the polystyrene shell; the core is rare earth luminescent nanoparticles, the silica shell is coated outside the core, and the silica shell is modified with double bonds; and the silica shell is coated with the polystyrene shell, and the polystyrene shell is modified with a functional group. The invention further discloses a preparation method of the rare earth nanomaterial containing the functionalized polystyrene shell. The rare earth nanomaterial containing the functionalized polystyrene shell has a good dispersity and a high stability, and can be applied to biological coupling, immunochromatography detection and hydrophobic molecule or nanoparticle embedding.

Description

technical field [0001] The invention belongs to the technical field of rare earth luminescent nanometer materials, and in particular relates to a rare earth nanometer material containing polystyrene shell and biological coupling and application thereof. Background technique [0002] Rare earth nanomaterials have good photostability and chemical stability, and have broad application prospects. Commonly used rare earth nanomaterials are obtained in oleic acid-octadecene mixed solvents, but the oleic acid ligands on the surface make the materials insoluble in water and difficult to perform surface functionalization, which greatly limits their applications in the biomedical field . [0003] At present, most rare earth nanomaterials are surface functionalized in the form of non-covalent bonds, such as hydrophilic-hydrophobic interactions, electrostatic adsorption, etc. F.Xu et al. used polyacrylic acid (PAA) to modify the surface of rare earth nanomaterials. Through the ligand ...

AI Technical Summary

Problems solved by technology

However, the disadvantages of the above method are: first, ligand exchange easily leads to aggregation between nanoparticles; The valency is much weaker, and it is easily disconnected by the influence of interfering substances in the solution, so the antibody on the particle surface may fall off at any time in a complex system

However, since silicon dioxide is obtained by the condensation reaction of silicon hydroxyl groups to form silicon-oxygen bonds, long-term storage in pure water will cause silicon-oxygen bond breaks and gradually dissolve, so the stability is difficult to guarantee

[0005] It has been reported in the literature that a polystyrene shell with a thickness of 10 nm can be grown on the surface of rare earth nanomaterials through seed polymerization with the assistance of polyvinylpyrrolidone (PVP). Under the steric hindrance effect, the encapsulated rare earth nanomaterials are well dispersed in pure water; however, the material still cannot be biocoupled; and the PVP adsorbed on the surface of polystyrene will gradually fall off after repeated washing, and the material Poor dispersibility of polystyrene shell; thinner polystyrene shell, insufficient suspending ability for core material, and ions in the solution are easy to diffuse into the core, which may cause corrosion and dissolution of rare earth nanomaterials

Images