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A gelatin-based bone tissue adhesive, its preparation method and application

A tissue adhesive and adhesive technology, applied in the field of materials, can solve the problems of poor mechanical properties, degradability and poor biocompatibility

Active Publication Date: 2021-07-06
海南德拉米克投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some adhesives in the prior art have poor mechanical properties and good degradability, and some have good mechanical properties, but poor degradability and biocompatibility.

Method used

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  • A gelatin-based bone tissue adhesive, its preparation method and application
  • A gelatin-based bone tissue adhesive, its preparation method and application
  • A gelatin-based bone tissue adhesive, its preparation method and application

Examples

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preparation example Construction

[0037] The present invention does not limit to the preparation method of described aldoglucose, those skilled in the art can be well known, preferably can be prepared as follows:

[0038] Dextran and sodium periodate are mixed and stirred for reaction, dialyzed, filtered and freeze-dried to obtain aldoglucose.

[0039] Firstly, dextran was dissolved in deionized water, sodium periodate was dissolved in deionized water, and sodium periodate solution was added dropwise to the dextran solution at room temperature, under the conditions of avoiding light and stirring, and then The reaction is carried out under magnetic stirring at room temperature and protected from light, and the reaction time is 4-6 hours.

[0040] After the reaction, add ethylene glycol to terminate the oxidation reaction, then transfer the reaction system to a dialysis bag with a molecular weight of 3500, place it in deionized water for dialysis for 36-48 hours, and replace the deionized water for dialysis ever...

Embodiment 1

[0067] Synthesis of Gelatin-Based Bone Tissue Adhesives Reinforced with Modified Bioactive Glass Nanoparticles:

[0068] 1. Preparation of Aldehyddextran

[0069] Dissolve 5g of dextran in 100ml of deionized water, 5g of sodium periodate in 60ml of deionized water, and add the sodium periodate solution dropwise into the dextran solution at room temperature, under the condition of avoiding light and stirring, Then magnetically stirred at room temperature and protected from light, and reacted for 6 h. After the reaction, 1ml of ethylene glycol was added to the reaction system to stop the oxidation reaction. Then transfer the reaction system to a dialysis bag with a molecular weight of 3500, and place it in deionized water for dialysis for 48 hours. The deionized water used for dialysis is replaced every 12 hours. After the dialysis is completed, the product obtained is filtered with filter paper. It was pre-frozen in the refrigerator, and then freeze-dried in a freeze dryer fo...

Embodiment 2

[0075] Embodiment 2 Characterization of physical and chemical properties of gelatin-based bone adhesive

[0076] 1. Fourier Transform Infrared Spectroscopy (FTIR)

[0077] Mix each group of gelatin-based bone adhesives after cooling and drying with potassium bromide at a mass ratio of 1 / 50 and grind them uniformly, and put them into a tablet machine to prepare corresponding sheet-like samples, using ATR- Scan the sample in FTIR mode, set the resolution to 4cm-1, and scan the wavelength to 400-4000cm-1, and analyze the similarities and differences of the chemical structure of the material before and after modification through different curves obtained.

[0078] The result is as figure 1 as shown, figure 1 .(a). Chemical schematic diagram and FTIR characterization of aldehyde dextran synthesis; (b). Chemical schematic diagram and FTIR characterization of bioactive glass amination modification. The present invention proves the successful synthesis of aldehydglucan and the amin...

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Abstract

The invention provides a preparation of modified nanoparticle-reinforced gelatin-based bone tissue adhesive, comprising: mixing aminated mesoporous bioactive nanoparticle (AMBGN) with a buffer solution of aldehyde glucose to obtain a pre-crosslinking solution, It is mixed with gelatin solution and placed on the cross-section of the bone block to be bonded. When the hydrogel is solidified, it can form adhesion to the bone tissue on both sides to achieve the effect of bone tissue bonding. After fixation, the adhesive can play a role Osteogenic activity of aminated mesoporous bioactive glass promotes healing of fracture surfaces. The AMBGN-reinforced bone adhesive has good mechanical and mechanical properties on the basis of retaining good bone tissue adhesion properties. It overcomes the cytotoxicity problem caused by the physical addition of nanoparticles and retains good biocompatibility. At the same time, the stable release of various ions such as calcium and silicon endows the adhesive with good in vitro and in vivo osteogenic activity, enabling it to effectively promote fracture healing on the basis of bonding bone tissue.

Description

technical field [0001] The invention relates to the technical field of materials, in particular to a gelatin-based bone tissue adhesive, its preparation method and application. Background technique [0002] In the clinical practice of orthopedics, some comminuted fractures or avulsion fractures often result in the appearance of small fracture fragments. The fixation of these small and irregular fracture fragments is difficult and controversial. If it is fixed, the wound may need to be enlarged, causing additional surgical injury; if it is not fixed, the micro-movement of the fracture fragment may affect the overall healing of the fracture, resulting in delayed union or even nonunion of the fracture. There is a dilemma in the fixation of this type of fracture, and there is a lack of a simple and reliable fixation method. [0003] As a common tool in the field of surgery, medical adhesive is widely used in general surgery and urology surgery. It is easy to apply and reliable ...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/10
CPCA61L24/001A61L24/0031A61L24/0042A61L24/104A61L2430/02
Inventor 陈亮顾勇崔文国唐锦程
Owner 海南德拉米克投资有限公司
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