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Oil-in-water type Pickering emulsion with stable ursolic acid and preparation method of oil-in-water type Pickering emulsion

A technology of Pickering emulsion and oil-in-water type, which is applied in the field of oil-in-water Pickering emulsion and its preparation, can solve the problems of inability to uniformly disperse the water phase, incompatibility, etc., and achieve the improvement of particle wettability, Effect of reducing particle size and improving stability

Inactive Publication Date: 2019-11-19
湖南先伟阳光生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the technical problem that the existing ursolic acid raw material is incompatible with water, and can not evenly disperse in the water phase, the object of the present invention is to provide a kind of ursolic acid, surfactant, protein colloid particles, polysaccharide colloid The preparation method of particle-stabilized oil-in-water Pickering emulsion, by constructing Pickering emulsion utilizing ursolic acid synergistic surfactant to prepare multi-layered microcapsule recombined powder, has green safety, good stability and compatibility High, good dispersibility, high uniformity, excellent instant solubility, etc.

Method used

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  • Oil-in-water type Pickering emulsion with stable ursolic acid and preparation method of oil-in-water type Pickering emulsion

Examples

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Effect test

Embodiment 1

[0037] The preparation method of Pickering emulsion and microcapsule powder of ursolic acid-stabilized pumpkin seed oil-whey protein-xanthan gum system:

[0038] Evenly disperse 2% ursolic acid in 2 times the mass of propylene glycol, add 1% phospholipids and mix well, then suspend the mixture in pumpkin seed oil, and use a high-speed homogeneous emulsifier at a speed of 20,000 rpm for homogenization 10 minutes. Then use a high-pressure homogenizer to carry out homogenization. The homogenization pressure conditions are as follows: the primary pressure is 60 MPa, and the secondary pressure is 10 MPa to obtain liquid A. Sucrose ester (0.05%) and Tween 80 (0.3%) were suspended in the pure water phase to prepare liquid B; whey protein (0.75%) and xanthan gum (0.02%) were suspended together in the pure water phase , to prepare liquid C. Under the condition of high-speed homogeneous emulsification, mix liquid A and liquid B at a volume of 1:1. The mixing condition is to drop liqui...

Embodiment 2

[0045] The preparation method of Pickering emulsion and microcapsule powder of ursolic acid-stabilized camellia oil-whey protein-carboxymethylcellulose sodium system:

[0046] Evenly disperse 2% ursolic acid in 2 times the mass of propylene glycol, add 1% phospholipid and mix well, then suspend the mixture in camellia oil, and use a high-speed homogeneous emulsifier at a speed of 20,000 rpm for 10 minute. Then use a high-pressure homogenizer to carry out homogenization. The homogenization pressure conditions are as follows: the primary pressure is 60 MPa, and the secondary pressure is 10 MPa to obtain liquid A. Sucrose ester (0.05%) and Tween 80 (0.3%) were suspended in pure water phase to prepare liquid B; whey protein (0.75%) and sodium carboxymethylcellulose (0.04%) were suspended together in pure In the water phase, liquid C was prepared. Under the condition of high-speed homogeneous emulsification, mix liquid A and liquid B at a volume of 1:1. The mixing condition is to...

Embodiment 3

[0052] The preparation method of the Pickering emulsion of ursolic acid-stabilized fish oil-soy protein isolate-sodium carboxymethylcellulose system and its microcapsule powder:

[0053] Evenly disperse 3% ursolic acid in 1.5 times the mass of propylene glycol, add 1% phospholipids and mix well, then suspend the mixture in fish oil, and use a high-speed homogeneous emulsifier at a speed of 20,000 rpm for 10 minutes. . Then use a high-pressure homogenizer for homogenization, the homogenization pressure conditions are: the primary pressure is 60MPa, the secondary pressure is 20MPa, and A liquid is obtained. Sucrose ester (0.05%) and Tween 80 (0.3%) were suspended in pure water phase to prepare liquid B; soybean protein isolate (1%) and sodium carboxymethylcellulose (0.04%) were suspended together in pure In the water phase, liquid C was prepared. Under the condition of high-speed homogeneous emulsification, mix liquid A and liquid B at a volume of 1:1. The mixing condition is ...

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Abstract

The present invention discloses an oil-in-water Pickering emulsion with stable ursolic acid and a preparation method of the oil-in-water type Pickering emulsion. The oil-in-water Pickering emulsion with the stable ursolic acid is prepared from the following raw materials in percentages by mass: 2-4% of ursolic acid, 2-8% of propylene glycol, 1-2% of phospholipid, 20-40% of functional grease, 0.04-0.2% of sucrose ester, 0.15-0.5% of tween 80, 0.5-1% of protein, 0.02-0.04% of a thickening agent and water. By constructing and utilizing the Pickering emulsion of the ursolic acid combined with a surfactant, multilayer microcapsule recombinant powder is prepared. The oil-in-water Pickering emulsion has characteristics of being green and safe, good in stability, high in compatibility, good in dispersibility, high in uniformity, excellent in instant solubility, etc.

Description

technical field [0001] The invention belongs to the technical field of gel emulsification preparations, in particular to an ursolic acid-stabilized oil-in-water Pickering emulsion and a preparation method thereof. Background technique [0002] Ursolic acid, also known as ursolic acid, has a wide range of pharmacological effects such as anti-hepatitis, anti-tumor, anti-inflammatory, anti-virus, lowering blood fat, anti-atherosclerosis and enhancing immunity, and has low toxicity and few adverse reactions. But because the solubility of ursolic acid in water is very small, the dissolution rate is slow, and the bioavailability is low, it belongs to the IV class drug (poor water solubility and poor absorption) in the biopharmaceutical classification system, so it is necessary to select a suitable dosage form to improve bioavailability Spend. [0003] At present, invention patents such as ursolic acid freeze-dried powder preparation, ursolic acid sustained-release tablet, ursolic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/56A61K47/10A61K47/22A61P1/16A61P3/06A61P9/10A61P29/00A61P31/14A61P31/20A61P35/00
CPCA61K9/107A61K31/56A61K47/10A61K47/22A61P1/16A61P3/06A61P9/10A61P29/00A61P31/14A61P31/20A61P35/00
Inventor 罗伟钟雨
Owner 湖南先伟阳光生物科技有限公司
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