Application of DEFA4 cytokine to preparation of medicaments for treating liver failure
A technology for liver failure and cytokines, applied in the fields of molecular medicine, biomedicine, and clinical medicine, which can solve problems such as shortage of donor livers and death of patients.
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Embodiment 1
[0042] Embodiment 1: Injection containing DEFA4 cytokines treats a large animal (young pig) model of liver failure
[0043] Animal model: 30 male Chinese young pigs (8-10 kg) were randomly divided into two groups, 15 in each group. Each young pig was injected with 1.5g / kg of D-gal via the jugular vein to create a liver failure model.
[0044] Test group: multiple intravenous injections of DEFA4 injection at fixed time points after D-gal injection, dose: 10ml / kg, twice a day.
[0045] Control group: inject the same amount of saline without DEFA4.
[0046] Neither the control group nor the experimental group received other drug treatment.
[0047] figure 1 It is a schematic diagram of the survival time curves of the young pigs of the experimental group and the control group, showing the survival rate of the young pigs of the experimental group and the control group. The results showed that the 3-day survival rate of young pigs in the treatment group containing DEFA4 cytokine...
Embodiment 2
[0048] Embodiment 2: The lyophilized powder injection containing DEFA4 cytokine treats the small animal (rat) model of liver failure
[0049] Animal model: 100 male rats (200-250 g) were randomly divided into two groups, 50 in each group. Each rat was intraperitoneally injected with D-gal 1.5g / kg to make a liver failure model. Prepare DEFA4 lyophilized powder and water for injection to form a suspension.
[0050] Experimental group: 4 ml of DEFA4 freeze-dried powder suspension was injected intraperitoneally at a fixed time point after D-gal injection, twice a day.
[0051] Control group: inject the same amount of saline without DEFA4.
[0052] Both the control group and the experimental group received no other drug treatment.
[0053] figure 2 Schematic diagram of the survival time curves of rats in the experimental group and the control group, figure 2The survival rate of the rats in the experimental group and the control group is shown: the results show that the rats ...
Embodiment 3
[0054] Embodiment 3: The suspension containing DEFA4 cytokine treats the rabbit model of hepatic failure
[0055] Animal model: 40 adult male rabbits (2000-2500 g) were randomly divided into two groups, 20 in each group. Each rabbit was intramuscularly injected D-gal 1.5g / kg to make a liver failure model.
[0056] Test group: intramuscular injection of DEFA4 suspension 20ml at fixed time points after D-gal injection, twice a day.
[0057] Control group: inject the same amount of saline without DEFA4.
[0058] Both the control group and the experimental group received no other drug treatment.
[0059] image 3 It is a schematic diagram of the survival time curves of rabbits in the experimental group and the control group, image 3 The survival rate of rabbits in the experimental group and the control group is expressed: the results show that the survival rate of the rabbits in the DEFA4 treatment group is 90% at 1 day, 90% at 7 days, and 90% at 14 days, while the control gr...
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